Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Journal of Clinical Microbiology and Infectious Diseases
Rastuti, Made Rina
Unknown Affiliation
Immunology & microbiology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Various types of extended spectrum β-lactamases: a literature review Rastuti, Made Rina; Budayanti, Ni Nyoman Sri; Dwija, Ida Bagus Nyoman Putra
Journal of Clinical Microbiology and Infectious Diseases Vol. 3 No. 2 (2023): Available online: December 2023
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v3i2.52

Abstract

The inappropriate use of antibacterials causes the spread of resistance in bacteria and increases the health burden of infection due to the nature of resistance to many classes of antibiotics which are referred to as multi-resistant (multidrug resistant). Extended spectrum β-lactamase (ESBL) is one of the enzymes that cause multi-resistance, where bacteria with this enzyme become resistant to third-generation cephalosporin antibiotics which are often used to treat gram-positive and gram-negative bacterial infections in humans with minimal side effects. β -lactamase is an enzyme capable of hydrolyzing the β-lactam ring in β -lactam class antibiotics so that antibiotics become inactive. Mutations in the gene that encodes this enzyme produce a β-lactamase enzyme which can break down the β-lactam ring in all penicillin and cephalosporin antibiotics. The classification of β-lactamases is complex due to genetic, biochemical properties, and substrate affinity for β-lactamase inhibitors. There are also various types of ESBL enzyme-coding genes including TEM, SHV, CTX-M, VEB, PER, OXA, SFO-1, BEL-1, BES-1, TLA-1, and GES. This study aims to review various types of extended-spectrum β-lactamases.
Co-Authors Dwija, Ida Bagus Nyoman Putra Ni Nyoman Sri Budayanti