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All Journal Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Indonesian Journal of Pharmacology and Therapy
Febriansah , Rifki
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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The Effect of Binahong (Anredera Cordifolia) Leaf Extract Intranasal Administration on the Safety of Olfactorius Nerves Wistar Rats Farhan, Ichsanul; Widuri , Asti; Febriansah , Rifki
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 2 No. 2 (2023): Strengthening Youth Potential for Sustainable Innovation
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v2i2.483

Abstract

Introduction – Binahong plant (Anredera cordifolia) is reported to contain bioactive compounds that are useful for treating several diseases. One of the effects thatcan be used is anti-inflammatory, so it has potential as an alternative to treat chronic inflammation of the nose, but which has not yet been done researched of safety against the olfactory nerve. Purpose – This study aims to determine the toxic effect of the ethanolic extract of Binahong (Anredera cordifolia) leaves on the safety of the olfactory nerves of Wistar rats. Methodology/Approach – This research is an experimental research using pre and post control group design. The samples used were 30 female Wistar rats aged 3 months which were divided into 6 groups. Group 1 was used as a normal control without treatment. Groups 2, 3, 4, 5 and 6 were treated with a nasal spray of Binahong leaf extract with concentrations of 5%, 10%, 25%, 50% and 75%, respectively. Before and after treatment, the rats were tested for smell by putting them in an empty cage that was fed under the bed and assessing the length of time the rats found food. The data obtained were tested using the t-test (t-test) to see the difference in the mean. Findings – This study showed that there was an effect of Binahong leaf extract (Anredera cordifolia) in reducing the average olfactory time of Wistar rats (241 seconds vs 316 seconds) but it was not statistically significant and no anosmia was found. Originality/ Value/ Implication – The results of this study provide new insights into the use of intranasal Binahong.
Potential active compounds of Streptomyces sennicomposti GMY01 for antiplasmodial and antiSARS-CoV-2 revealed by targeted metabolomic and molecular docking Damayanti, Ema; Nisa, Khoirun; Febriansah , Rifki; Hadi, Ismanurrahman; Dinoto, Achmad; Widada, Jaka; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 5 No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9825

Abstract

Streptomyces sennicomposti GMY01 is a bacterium with huge biotechnological potential that revealed by genome mining analysis. This research aimed to investigate the potential compounds as antiplasmodial and the antiSARS-CoV-2 from the S. sennicomposti GMY01 using targeted metabolomic and in silico molecular docking. The crude extract was obtained by extraction of supernatant from fermentation product of the S. sennicomposti GMY01. The secondary metabolite profiling was obtained by using ultra-high-performance liquid chromatography (UHPLC) coupled to targeted high-performance mass spectrometry (HRMS) based on genome mining data of whole genome sequence (WGS). In silico molecular docking was performed on important target protein of P. falciparum i.e. glutathione reductase (PfGR), lactate dehydrogenase (PfLDH), phosphoethanolamine methyltransferase (Pfpmt), erythrocyte membrane protein 1 (PfEMP1) and glutathione-S-transferase (PfGST); and of SARS-CoV-2 proteins i.e. protease domain, spike glycoprotein, receptor-binding domain angiotensin-converting enzyme 2 (RBD-ACE2), 3-chymotrypsin-like protease (3CLpro), and RNA-dependent RNA polymerase (RdRp). One compound from S. sennicomposti GMY01 extract, albaflavenone was confirmed by targeted LC-HRMS. On molecular docking analysis, albaflavenone showed higher affinity than chloroquine as antiplasmodial drug and exhibited same affinity to remdesivir as antiSARS-CoV-2. Stertomyces sennicomposti GMY01 has promising biotechnological potential for drug development as antiplasmodial and anti-SARS-CoV-2 agent. Further study is needed, especially regarding in vitro testing of albaflavenone as antiplasmodial and antiSARS-CoV2.
Co-Authors Achmad Dinoto Ema Damayanti Farhan, Ichsanul Hadi, Ismanurrahman JAKA WIDADA Khoirun Nisa Mustofa Mustofa Widuri , Asti