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All Journal Jurnal Agroristek Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding
Ambarita, Theresia
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Public Health Social Sciences

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Transition Metals Based Anti-Alzheimer Ambarita, Theresia; Pasaribu, Cinta Johanna Tessalonika
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 2 No. 2 (2023): Strengthening Youth Potential for Sustainable Innovation
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v2i2.524

Abstract

Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common cause of dementia. Amyloid-B protein’s accumulation in amyloid plaques, oxidative stress, tau protein phosphorylation, poor energetics, mitochondrial dysfunction, membrane lipid dysregulation, inflammation, and neurotransmitter pathway disruption, play a part in the pathophysiology of Alzheimer's disease. AD is primarily characterized by the formation of amyloid-B aggregates. Transition metal complexes have recently been produced as chemical reagents for modifying AB aggregation. Transition metal complexes have tunable features such as the metal center's oxidation and spin states, as well as its coordination structure by altering the ligand bound to the metal center. These variable properties result in the reactivity of transition metal complexes with AB species and may lead to the regulation of the AB aggregation pathway. The purpose of this study is to describe the application of transition metals as active compounds in anti-Alzheimer's disease drugs. This study was compiled from online journals using secondary data searched by keyword. The results of the study show that some transition metals have potential therapeutic effects for AD. Ru can be an AB aggregation inhibition. Fe, Cu, and Zn transition metals are necessary for human survival and involved in AD triggering. Pt, Ni, Co, and V complexes play a role as multifunctional therapeutic agents against AD. This literature review includes a recently published (year>2000) report on the role of transition metals as anti-Alzheimer's.
PENYERAPAN LOGAM BERAT TIMBAL (PB) DALAM AIR LINDI TPA TERJUN MARELAN MENGGUNAKAN TANAMAN ECENG GONDOK (EICHHORNIA CRASSIPES) Sofia, Mukhaira; Simanjuntak, Wiwin Yulianti; Maysara, Lusi; Ambarita, Theresia; Febriyossa, Adelia; Sari Rangkuti, Marlinda Nilan
Jurnal Agroristek Vol 7, No 2 (2024): Agustus 2024
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Jabal Ghafur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47647/jar.v7i2.2726

Abstract

Penelitian ini bertujuan untuk mengukur efektivitas tanaman eceng gondok (Eichhornia crassipes) dalam menyerap logam berat timbal (Pb) dari air lindi di TPA Terjun Marelan menggunakan sistem constructed wetland. Air lindi yang dihasilkan dari proses dekomposisi sampah di TPA mengandung polutan berbahaya, termasuk timbal (Pb), yang dapat berdampak buruk terhadap kesehatan manusia dan lingkungan. Eceng gondok dikenal memiliki kemampuan fitoremediasi yang efektif untuk menyerap logam berat melalui akarnya. Penelitian ini dilakukan dengan variasi konsentrasi air lindi (0%, 25%, 50%, dan 100%) selama 7 hari. Hasil penelitian menunjukkan bahwa eceng gondok mampu menurunkan konsentrasi timbal (Pb) dan meningkatkan pH air lindi, namun pada konsentrasi air lindi yang tinggi terjadi kerusakan morfologi tanaman. Secara keseluruhan, eceng gondok efektif sebagai agen fitoremediasi untuk mengurangi pencemaran logam berat timbal (Pb) dari air lindi TPA, meskipun terdapat dampak negatif pada kondisi tanaman akibat paparan air limbah
Co-Authors Adelia Febriyossa Maysara, Lusi Pasaribu, Cinta Johanna Tessalonika Sari Rangkuti, Marlinda Nilan Simanjuntak, Wiwin Yulianti Sofia, Mukhaira