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In-Silico Analysis of Agrocybe aegerita Bioactive Compounds Targeting HER-2 Positive Breast Cancer Protein Moses, Iyekekpolor Osamudiame
Journal of Multidisciplinary Science: MIKAILALSYS Vol 2 No 3 (2024): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v2i3.3866

This study explores the anti-cancer potential of bioactive compounds derived from Agrocybe aegerita, focusing on their interaction with the HER-2 protein, which is commonly overexpressed in aggressive breast cancers. Using in-silico molecular docking techniques via the SwissDock platform and AutoDock Vina algorithm, the binding affinities of three bioactive compounds—ceramide, ganoderic acid, and galectin—were evaluated and compared to standard cancer drugs, including doxorubicin, lapatinib, and pazopanib. The results demonstrated that ganoderic acid exhibited the highest binding affinity to HER-2 (-6.34 to -6.18), comparable to lapatinib and pazopanib, suggesting its strong therapeutic potential. Ceramide and galectin showed moderate affinities, indicating possible roles in complementary or synergistic therapies. The findings suggest that A. aegerita, particularly its ganoderic acid compound, holds promise as a natural source for novel anti-cancer agents, potentially offering comparable efficacy to synthetic drugs with fewer side effects. However, the limitations of in-silico studies are acknowledged, and further in vitro and in vivo validation is necessary to confirm these promising results. This research contributes to the growing body of knowledge on natural bioactive compounds, underscoring the potential of mushrooms in cancer therapy and advocating for more extensive studies to harness their medicinal properties.

The Rise of Biochemical Sensors: Technology for Real-Time Health Monitoring (Applications and Future Scope) Moses, Iyekekpolor Osamudiame
Journal of Multidisciplinary Science: MIKAILALSYS Vol 2 No 3 (2024): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v2i3.3907

Biochemical sensors integrated into wearable health technology represent one of the most transformative innovations of the 21st century. This review delves into the evolution, principles, and real-time applications of biochemical sensors and their role in personalized health monitoring. Wearable biochemical sensors, capable of continuously measuring various biomarkers like glucose, lactate, cortisol, and electrolytes, are revolutionizing healthcare by enabling proactive management of chronic diseases, including diabetes, cardiovascular disorders, and mental health issues. Advances in biosensing technologies, coupled with the use of AI and machine learning algorithms, have enhanced the sensitivity and accuracy of these devices, ensuring that critical health data is available in real-time. From glucose monitoring devices like Abbott's FreeStyle Libre to the latest nanomaterial-based sensors, these innovations are reshaping healthcare delivery by shifting the focus from hospital-centered treatments to patient-centric, continuous monitoring systems. This review provides an in-depth analysis of the technological advancements, challenges, and future directions in biochemical sensors, focusing on key technologies such as electrochemical, optical, and enzymatic sensors. It also highlights the critical role of AI in interpreting the complex data generated by these sensors, paving the way for more efficient diagnostics and predictive healthcare models. Furthermore, the paper explores how these sensors have been applied in infectious disease detection, particularly during the COVID-19 pandemic, and discusses their potential to enhance global health surveillance systems. In conclusion, wearable biochemical sensors represent a significant leap forward in the pursuit of personalized medicine, offering real-time diagnostics and timely interventions for disease management. The future of healthcare is closely tied to the ongoing innovations in sensor technology, with the promise of even more advanced and multifunctional devices on the horizon.

Oyster Mushroom in Bioremediation: A Review of Its Potential and Applications Moses, Iyekekpolor Osamudiame
Journal of Multidisciplinary Science: MIKAILALSYS Vol 3 No 1 (2025): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v3i1.4362

Oyster mushrooms (Pleurotus spp.), a widely cultivated edible fungus, hold immense potential in the field of bioremediation due to their unique physiological and enzymatic capabilities. Bioremediation is an eco-friendly process that employs biological systems to degrade, immobilize, or transform environmental pollutants, such as heavy metals, polycyclic aromatic hydrocarbons (PAHs), pesticides, and synthetic dyes, into less toxic or reusable forms. Oyster mushrooms stand out due to their ability to grow on diverse substrates, rapid growth rates, and secretion of ligninolytic enzymes, such as laccases and manganese peroxidases, which break down complex pollutants. Additionally, their mycelial networks exhibit biosorption properties that effectively bind and immobilize heavy metals, making them ideal candidates for mycoremediation. This review explores the mechanisms underlying the bioremediation capabilities of oyster mushrooms, focusing on enzymatic degradation of organic pollutants and biosorption of heavy metals. Furthermore, the economic and environmental advantages of using oyster mushrooms in bioremediation are discussed, including cost-effectiveness, dual benefits of waste recycling and edible mushroom production, and adaptability to various environmental conditions. The paper also highlights challenges such as enzyme specificity, scalability, and secondary metabolite toxicity. Future research directions include genetic engineering to enhance enzymatic efficiency, co-cultivation strategies with other microorganisms, and field trials to validate laboratory findings. Oyster mushrooms thus represent a sustainable, versatile, and efficient approach to addressing global pollution challenges.

Comparative Study on the Phytochemical and Micronutrients Levels in Selected Edible Mushroom Samples Abah, Moses Adondua; Adebisi, Arowora Kayode; Moses, Iyekekpolor Osamudiame; Dooshima, Arowora Mercy; Umaru, Isaac John; Uchechukwu, Ukoh Daniel; Timothy, Mgbede
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3707

Edible mushrooms have been known to possess various phytochemical and micro nutrient levels. Edible mushrooms can be eaten and they supply nutritional benefits to the human body system. It is not widely consumed mainly due to paucity of information about it. Therefore, this research was conducted to compare the phytochemicals and micronutrients levels in two selected edible mushrooms (Pleurotus ostreatus and Agrocybe aegerita). Fully matured mushroom species of Oyster and Tea tree mushroom were collected, air dried and then stored in transparent polythene bags. Quantitative determination of phytochemicals and micronutrients (minerals and vitamins) present was carried out. Tea tree mushroom used in this research can be said to have the higher concentration of phytochemicals (phenols and poly-phenols), as there was no significant difference (p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for phenols and poly-phenols. The results obtained from this research indicated that there was no significant decrease(p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for Sodium, Iron, Magnesium, Selenium, Manganese. While there was a non-significant increase (p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for Potassium, Calcium, Phosphorus, Copper. Tea tree mushroom had higher composition of vitamins A and C than oyster mushroom which were not significantly different (p>0.05). The findings in this study revealed that Tea tree mushroom (Agrocybe aegerita) is slightly better than Oyster mushroom (Pleurotus ostreatus) based on their phytochemicals and micronutrients (minerals and vitamins).

Comparative Study on the Phytochemical and Micronutrients Levels in Selected Edible Mushroom Samples Abah, Moses Adondua; Adebisi, Arowora Kayode; Moses, Iyekekpolor Osamudiame; Dooshima, Arowora Mercy; Umaru, Isaac John; Uchechukwu, Ukoh Daniel; Timothy, Mgbede
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3707

Edible mushrooms have been known to possess various phytochemical and micro nutrient levels. Edible mushrooms can be eaten and they supply nutritional benefits to the human body system. It is not widely consumed mainly due to paucity of information about it. Therefore, this research was conducted to compare the phytochemicals and micronutrients levels in two selected edible mushrooms (Pleurotus ostreatus and Agrocybe aegerita). Fully matured mushroom species of Oyster and Tea tree mushroom were collected, air dried and then stored in transparent polythene bags. Quantitative determination of phytochemicals and micronutrients (minerals and vitamins) present was carried out. Tea tree mushroom used in this research can be said to have the higher concentration of phytochemicals (phenols and poly-phenols), as there was no significant difference (p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for phenols and poly-phenols. The results obtained from this research indicated that there was no significant decrease(p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for Sodium, Iron, Magnesium, Selenium, Manganese. While there was a non-significant increase (p>0.05) in Oyster mushroom in comparison to Tea tree mushroom for Potassium, Calcium, Phosphorus, Copper. Tea tree mushroom had higher composition of vitamins A and C than oyster mushroom which were not significantly different (p>0.05). The findings in this study revealed that Tea tree mushroom (Agrocybe aegerita) is slightly better than Oyster mushroom (Pleurotus ostreatus) based on their phytochemicals and micronutrients (minerals and vitamins).

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