<![CDATA[Biochemical sensors integrated into wearable health technology represent one of the most transformative innovations of the 21st century. This review delves into the evolution, principles, and real-time applications of biochemical sensors and their role in personalized health monitoring. Wearable biochemical sensors, capable of continuously measuring various biomarkers like glucose, lactate, cortisol, and electrolytes, are revolutionizing healthcare by enabling proactive management of chronic diseases, including diabetes, cardiovascular disorders, and mental health issues. Advances in biosensing technologies, coupled with the use of AI and machine learning algorithms, have enhanced the sensitivity and accuracy of these devices, ensuring that critical health data is available in real-time. From glucose monitoring devices like Abbott's FreeStyle Libre to the latest nanomaterial-based sensors, these innovations are reshaping healthcare delivery by shifting the focus from hospital-centered treatments to patient-centric, continuous monitoring systems. This review provides an in-depth analysis of the technological advancements, challenges, and future directions in biochemical sensors, focusing on key technologies such as electrochemical, optical, and enzymatic sensors. It also highlights the critical role of AI in interpreting the complex data generated by these sensors, paving the way for more efficient diagnostics and predictive healthcare models. Furthermore, the paper explores how these sensors have been applied in infectious disease detection, particularly during the COVID-19 pandemic, and discusses their potential to enhance global health surveillance systems. In conclusion, wearable biochemical sensors represent a significant leap forward in the pursuit of personalized medicine, offering real-time diagnostics and timely interventions for disease management. The future of healthcare is closely tied to the ongoing innovations in sensor technology, with the promise of even more advanced and multifunctional devices on the horizon.]]>
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