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All Journal CRJIM (Clinical and Research Journal in Internal Medicine) Pediatric Sciences Journal
Hapsari, Aulia Sita
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Comparison efficacy and safety sodium valproate versus combination sodium valproate and levetiracetam for treatment epilepsy in children: a meta-analysis Gasti, Detria Rahma; Hapsari, Aulia Sita; Ulifah, Karima Iffani
Pediatric Sciences Journal Vol. 4 No. 2 (2023): (Available online: 1 December 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i2.54

Abstract

Background: The most prevalent severe neurological condition, impacting more than 50 million individuals globally, is epilepsy. A new anti-epileptic drug (AED) called levetiracetam (LEV) has shown promise as an adjuvant treatment for children's treatment-resistant partial-onset seizures. Sodium valproate (SV) is a commonly used anti-epileptic medication that has a range of effects and a distinct mode of action. Combining LEV and SV has emerged as a viable clinical treatment plan. This study aimed to use meta-analysis to estimate the safety and effectiveness of LEV with SV in pediatric epilepsy patients. Methods: From January 1993 to April 2023, the Cochrane Library, PubMed, and ScienceDirect were searched. The included literature consisted of randomized controlled clinical trials that examined the use of SV in conjunction with LEV in pediatric epileptic patients. This meta-analysis followed the PRISMA guidelines. The statistical program used for the meta-analysis was Revman V.5.4.1. Results: From 568 original titles screened, data were extracted from 3 studies (n=303). Compared with SV alone, SV combined with LEV significantly improved the overall therapeutic effect of epilepsy (OR=0.80; 95%CI= 0.72-0.89; p<0.0001). The observation group significantly reduced the occurrence of adverse drug reactions (ADRs) of nausea and vomiting (OR=2.77; 95%CI=1.08-7.09; p=0.03). Conclusion: According to this meta-analysis, SV plus LEV considerably increased the overall therapeutic effect of epilepsy while concurrently lowering the incidence of ADRs when compared to SV alone. Thus, for treating epilepsy in children, we advise SV in conjunction with LEV.
Prevalence and Clinical Characteristics of Anemia Among Adults in a Highland Rural Community of East Java, Indonesia: Anemia in a Highland Village of East Java Nurarifah, Nina; Hermanto, Djoko Heri; Wardhani, Shinta Oktya; Brahmantyo, Herwindo Pudjo; Putri, Rakhmi Tika; Nainggolan, Freddy Chandra; Hapsari, Aulia Sita
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.07

Abstract

Anemia is a persistent global health challenge, particularly affecting women of reproductive age and residents of rural regions. This descriptive cross-sectional study assessed the prevalence and clinical characteristics of anemia among adult residents of Ngadas Village, a highland community in East Java, Indonesia. A total of 57 adults (48 females, 9 males) participated in a single-day community screening conducted by the Faculty of Medicine, Brawijaya University. Data collection included structured questionnaires, clinical examinations, and hemoglobin testing using the Sinocare H101 analyzer. The mean hemoglobin level was 14.6 ± 1.7 g/dL, with an overall anemia prevalence of 7.0%, indicating mild public health significance according to WHO classification. Fatigue (35.1%) and dizziness (49.1%) were the most common symptoms, whereas clinical signs such as pallor and cheilitis were infrequent. Women of reproductive age predominated, yet no pregnant respondents were anemic, suggesting the possible effectiveness of iron–folate supplementation programs. Although dietary protein and iron intake appeared adequate, frequent tea and coffee consumption among women (62.5%) could inhibit non-heme iron absorption. The findings underscore the predominance of subclinical anemia and the need for routine hemoglobin screening and targeted nutrition education. Strengthening preventive strategies in rural highland communities remains essential to sustain low anemia prevalence and improve public health outcomes.
Co-Authors Brahmantyo, Herwindo Pudjo Gasti, Detria Rahma hermanto, djoko heri Nainggolan, Freddy Chandra Nurarifah, Nina Putri, Rakhmi Tika Shinta Oktya Wardhani, Shinta Oktya Ulifah, Karima Iffani