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All Journal Pharmaceutical Sciences and Research (PSR) Helium: Journal of Science and Applied Chemistry
Prakoso, Muhamad Iqbal
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Photodegradation Of Methyl Orange (MO) Using TiO2/Zeolite From Coal Fly Ash Waste Under Acidic Conditions and H2O2 Addition Prakoso, Muhamad Iqbal; Maharani, Khairy Yunda; Ariq, Muhammad Rizki; Indah, Amalia Nurul; Apriansyah, Apriansyah; Iryani, Ani; Kusumawardani, Linda Jati; Syahputri, Yulian
Helium: Journal of Science and Applied Chemistry Vol 4, No 1 (2024): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v4i1.9503

Abstract

This study aims to degrade methyl orange dye by a photocatalytic method using TiO2/zeolite nanocomposite. The zeolite used is sourced from coal waste fly ash. While the TiO2/Zeolite nanocomposites were synthesized by the sol-gel method and analyzed using UV-Vis DRS to determine the band gap energy. The band gap energy obtained from calculation results of the Kubelka-Munk formula shows a value of 2.0 eV. This indicates that the working area of methyl orange photodegradation using TiO2/zeolite is in visible light. Optimization of the methyl orange photodegradation process in this study will be carried out in an acidic environment by varying the nanocomposite dose (0.05; 0.1; 0.2; 0.3; and 0.4 g) and the length of time of irradiation (15; 30; 45; 60; and 75 minutes). This study also conducted a study on the effect of adding H2O2. The optimum yield of percent degradation (%D) of methyl orange (MO) obtained was 98.37% from initial concentration 10 mg/L to 0,16 mg/L with varying doses of TiO2/zeolite 0.1 g and 30 minutes in an acidic environment and the addition of H2O2.
Identification of Active Compounds and Antidiabetic Activity of Red Shoot (Syzygium myrtifolium) Leaves Extract With In Vitro and In Silico Methods Prakoso, Muhamad Iqbal; Warnasih, Siti
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red shoot leaves were tested in vitro method for α-glucosidase inhibitory activity. The most active extract was analyzed using gas chromatography–mass spectrometry (GC–MS) to identify its chemical constituents. The identified compounds were then tested in silico using the molecular docking method to simulate interactions with the α-glucosidase receptor. The ethanol extract showed the strongest α-glucosidase inhibitory activity (IC₅₀ = 83.69 ppm), as compared to the ethyl acetate and n-hexane extracts. GC–MS analysis identified 5 secondary metabolites, predominantly terpenoids. Molecular docking revealed that three compounds includes α-Gurgujene, farnesyl acetate and Neophytadiene exhibited strong binding affinities (ΔG), hydrogen bonds and nteractions with the same amino acid residues as the standard control acarbose, indicating potential α-glucosidase inhibitory activity. These findings suggest that red shoot leaves extract, particularly its ethanol extract, contains bioactive compounds with promising potential as natural antidiabetic agents, warranting further pharmacological and clinical investigation.
Co-Authors . Apriansyah Ariq, Muhammad Rizki Indah, Amalia Nurul Iryani, Ani Linda Jati Kusumawardani Maharani, Khairy Yunda Siti Warnasih Yulian Syahputri