The purpose of this study is to describe the process or mechanism of Islamic nuanced mayang tatamba carried out by the Dayak tribe in Central Kalimantan. Field studies (field research) were used in this study with results in the form of sentences (descriptive). For data collection, it was conducted through interview techniques to 5 subjects who were found to have knowledge and experience regarding mayang tatamba from 5 regions in Prov. Central Kalimantan are: East Kotawaringin Regency (Sampit City and Tinduk Village), Katingan Regency (Tumbang Samba Village), Gunung Mas Regency (Tampelas Village), North Barito Regency (Sikui Village) and South Barito Regency (Babai Village). Then continued the validation stage using trianggulation techniques and sources followed by the analysis stages, namely: a. data reduction, b. data presentation, and c. conclusions. The results showed that tatamba mayang can be said to be one of the local cultures of the Dayak tribe with Islamic nuances because in the process or mechanism: 1. begins by saying basmalah and ends hamdalah which signifies following the advice of the Prophet Muhammad that when starting a work should be preceded and ended by remembering again to praise Allah Swt, 2. there is a word of surrender to Allah Almighty as the Creator who wants healing from Him for all diseases and 3. there is a form of flattery to the Prophet Muhammad (peace be upon him). The confusion in the process or mechanism of mayang management lies in the use of animals (black roosters / cemani), because there is no correlation to put or transfer diseases in this way.