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All Journal Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Narra X Medistra Medical Journal (MMJ)
Ginting, Franciscus
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Factor Influencing Mortality in Moderate - Severe Covid-19 Patients In Tertiary Hospital, Indonesia Faried, Mukhamad; Ginting, Franciscus; Kembaren, Tambar; Eyanoer, Putri Chairani
Journal of Society Medicine Vol. 2 No. 7 (2023): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i7.70

Abstract

Introduction: Covid-19 is highly contagious respiratory tract infection caused by infection of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This infection has a case fatality rate in those with moderate – severe case up to 30%. This study aims to analyse factor influencing mortality in moderate to severe Covid-19. Method: This study was conducted using retrospective cohort study on moderate - severe Covid-19 patients who were treated in tertiary hospital in Medan, Indonesia, in March 2020-June 2022. Results: From 180 moderate – severe Covid-19 inpatients, up to 37,8% died. Factor that influences the mortality is the presence of comorbidity (P=0,001), such as hypertension and chronic kidney disease (CKD), high levels of neutrophil-lymphocyte Ratio (NLR), procalcitonin, c-reactive protein (CRP), D-dimer, and low levels of albumin with P values 0,016, 0,036, 0,001, 0,001, 0,001, 0,003, and 0,006 consecutively. Conclusion: It can be concluded that the demographic factors that are significantly related to the death of Covid-19 patients are the presence of comorbidities such as hypertension and CKD.
Analysis of Differences in Germ Patterns in Pus Culture and Tissue Culture Examination in Patients with Diabetic Foot Ulcers at H. Adam Malik General Hospital, Medan Harahap, Roni Ananda Perwira; Ginting, Franciscus; Sihotang, Lenni Evalena
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.20207

Abstract

Background: Diabetic foot ulcer (DFU) is one of the chronic complications of diabetes mellitus that can increase the risk of amputation and lead to high treatment costs if the infection is not properly managed. Identifying the etiology of the infection is crucial for determining effective treatment. However, in Indonesia, particularly at H. Adam Malik General Hospital in Medan, there has been no clear study focusing on identifying diabetic foot infection patterns based on tissue culture. The Infectious Diseases Society of America (IDSA) 2023 recommends using tissue culture techniques for bacterial identification, moving away from pus cultures. Objective: This study aims to analyze the differences in infection patterns obtained through pus culture and tissue culture in patients with diabetic foot ulcers. Methods: This prospective descriptive study involved 41 patients treated at H. Adam Malik General Hospital, Medan. Ulcer samples were collected using two methods: sterile swabs for pus culture and tissue samples for tissue culture. The culture results were analyzed using the Kruskal-Wallis statistical test to compare the differences in bacterial patterns. Results: Gram-negative bacteria dominated both culture methods, with Pseudomonas spp being the most common in pus cultures and Escherichia coli in tissue cultures. A significant difference was found between the two methods in bacterial identification (p < 0.05).Conclusion: There is a significant difference between tissue culture and pus culture in diabetic foot ulcers, particularly in the number and types of bacterial isolates, with a p-value of 0.002. This difference is not coincidental, supporting IDSA’s recommendation to prioritize tissue culture over swab culture. These findings are consistent with other studies in the field.
Human Monkeypox Virus infection br tarigan, junita; Putri, Maulinda; Br. Purba, Sri Ulina; Ginting, Franciscus
Medistra Medical Journal (MMJ) Vol 3 No 1 (2025): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3jp6vr60

Abstract

Monkeypox is a zoonotic disease. First, this infection was found in animals but has been widespread in humans and become a pandemic all over the world including Indonesia with different case fatality rates caused by monkeypox infection among the countries. Some clinical features caused by monkeypox infection are similar to other infections caused by chicken pox and other viruses. Treating and preventing monkeypox infection need holistic management among medical personnel.
Antimicrobial resistance and empirical antibiotic use in diabetic foot infections: A retrospective study from Indonesia Tarigan, Menang B.; Saragih, Rama M.; Tarigan, Kevin A.; Ginting, Franciscus
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2895

Abstract

Diabetic foot infection (DFI) represents a major complication of diabetes mellitus with significant morbidity, frequently leading to amputation if not optimally managed. The aim of this study was to analyze clinical, microbiological, and antibiotic susceptibility data from patients with type 2 diabetes who presented with foot infections in Indonesia. The retrospective study, conducted at St. Elisabeth Hospital in North Sumatra, Indonesia, predominantly comprised male farmers with a mean diabetes duration of 8.6 years, most of whom exhibited advanced ulcer severity (64.5% at Wagner grade III). Surgical debridement was performed in 79.0% cases, and amputation in 21.0% of cases. Laboratory investigations revealed poor glycemic control (mean HbA1c 10.12%) and biochemical markers indicative of systemic inflammation and renal impairment. Microbial cultures identified a predominance of Gram-negative bacteria (58.1%), primarily Klebsiella pneumoniae, Proteus mirabilis, and Escherichia coli, whereas Gram-positive isolates (41.9%) were dominated by Staphylococcus aureus, including methicillin-resistant strains. Empirical outpatient and inpatient antibiotic regimens commonly included amoxicillin, ciprofloxacin, metronidazole, and ceftriaxone; however, in vitro susceptibility testing demonstrated limited efficacy of β-lactams such as ampicillin and amoxicillin (<10% sensitivity). In contrast, linezolid, amikacin, vancomycin, carbapenems, and fosfomycin exhibited superior activity against the isolated pathogens. These findings emphasize the critical need for empirical antibiotic guidelines tailored to local microbial ecology and resistance profiles, integrated with early surgical management, stringent glycemic control, and multidisciplinary care. This comprehensive approach is essential to reduce the risk of amputation and improve clinical outcomes in tropical, resource-limited settings.
Relationship between serum glutamine levels and mortality in sepsis patients: A single-center study in Indonesia Sihite, Enola GA.; Ginting, Franciscus; Sihotang, Lenni
Narra X Vol. 3 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i3.238

Abstract

Glutamine is a conditionally essential amino acid that plays a critical role in immune function, intestinal integrity, and metabolic homeostasis. Alterations in serum glutamine levels have been observed in critically ill patients, including those with sepsis. The aim of this study was to examine the association between serum glutamine levels and in-hospital mortality among sepsis patients. A retrospective cross-sectional study was conducted from April to June 2025 at a tertiary university hospital in Indonesia, including 36 adult patients diagnosed with sepsis. Serum glutamine levels were measured within the first 24 hours of admission. Median serum glutamine levels were significantly lower in non-survivors compared with survivors (2.53 vs 4.96 ng/mL; p=0.001). Serum glutamine levels were also negatively correlated with disease severity as assessed by the Sequential Organ Failure Assessment (SOFA) score (r=−0.447, p=0.006). Lower serum glutamine levels were associated with increased in-hospital mortality and greater organ dysfunction among sepsis patients. These findings suggest that serum glutamine reflects metabolic stress and disease severity rather than serving as a standalone prognostic biomarker.
Co-Authors br tarigan, junita Br. Purba, Sri Ulina Faried, Mukhamad Harahap, Roni Ananda Perwira Kembaren, Tambar Putri Chairani Eyanoer, Putri Chairani Putri, Maulinda Saragih, Rama M. Sihite, Enola GA. Sihotang, Lenni Sihotang, Lenni Evalena Tarigan, Kevin A. Tarigan, Menang B.