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All Journal MNJ (Malang Neurology Journal) The Journal of Society Medicine (JSOCMED)
Rambe, Avie Hanindya Dwiyanti
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation between Serum Fibrinogen Level and Acute Ischemic Stroke Severity Rambe, Avie Hanindya Dwiyanti; Batubara, Chairil Amin
Journal of Society Medicine Vol. 2 No. 8 (2023): August
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i8.79

Abstract

Introduction: Indonesia still has a high burden for stroke, and stroke became the number one cause of mortality, in which the condition caused 328,5 thousand deaths (21,2% of death from all cause) in 2012 according to WHO. Until now, there are multiple parameters that can be used to determine the severity of an acute ischemic stroke event, one of the laboratory parameters being serum fibrinogen level. The aim of this study was to find the relationship between serum fibrinogen level and the severity of acute ischemic stroke. Method: The study used a cross-sectional design from acute ischemic stroke patients in the inpatient wards of H. Adam Malik Medan Hospital and network hospital. We used contingency coefficient correlation analysis test to determine the relationship between serum fibrinogen level and the severity of acute ischemic stroke. This study involved 40 acute ischemic stroke patients. Results: The results of statistical analysis found a significant positive correlation between serum fibrinogen level and acute ischemic stroke severity with weak correlation strength (p=0.028; r= 0.328) with the median NIHSS score of the subject 6,5 and median serum fibrinogen level being 320,9mg/dL (87 – 881mg/dL). Conclusion: There was a significant relation between serum fibrinogen level and acute ischemic stroke severity. The result of this study proved that a higher serum fibrinogen level is associated with increased stroke severity.
EFFECT OF Centella asiatica AND Nigella sativa EXTRACTS AS ANTICONVULSANTS IN PENTYLENETETRAZOLE-INDUCED EPILEPSY MODEL Rambe, Avie Hanindya Dwiyanti; Batubara, Chairil Amin; Fitri, Aida
MNJ (Malang Neurology Journal) Vol. 12 No. 1 (2026): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.01.07

Abstract

Background: Epilepsy is a neurological disorder that is still widely found. The main goal of epilepsy therapy is for epilepsy patients to achieve an optimal quality of life with minimal therapeutic side effects. The active compounds in Centella asiatica and Nigella sativa have shown anticonvulsant effects. Objective: To determine the difference in anti-convulsant effects on the administration of Centella asiatica and Nigella sativa extracts in pentylenetetrazole-induced acute epilepsy model. Methods: This experimental study was conducted using 28 male Swiss divided into 7 equally large groups. The study was conducted with CMC Na 0.5% as a negative control and oral Phenitoin 25mg/Kg as a positive control, and 5 treatment groups were given C. asiatica extracts 800mg/Kg and 1000mg/Kg, N. sativa 800mg/Kg and 1000mg/Kg, and a mixture of C. asiatica 400mg/Kg and N. sativa 400mg/Kg orally. On the 7th day, seizure induction with pentylenetetrazole was performed, then measurements were taken. Results: There was significant difference on the seizure onset (p<0.001). In the experimental group, the longest onset we found was in the C. asiatica extract 1000mg/Kg group (99.25 ± 42.96 seconds). There was a significant difference in the total duration of seizure in C. asiatica 1000mg/Kg (p=0.031), N. sativa 800mg/Kg (p= 0.041), and N. sativa 1000mg/Kg (p= 0.030) groups. Conclusion:  Administration of C. asiatica 1000mg/Kg and N. sativa 800 and 1000mg/Kg extracts had an anticonvulsant effect on the duration of seizures.
Co-Authors Chairil Amin Batubara Fitri, Aida