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Njoku, Chinomso Juliet
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Physicochemical, Antimicrobial, Lethality and In Vitro Antioxidant Profiles of Johnu Tisane: A Coffee (Coffea Arabica) Leaf Decoction Formula Egbuonu, Anthony Cemaluk Chinedum; Alaebo, Prince Ogochukwu; Onuoha, Udumma Nsofor; Njoku, Chinomso Juliet; Obike, Chiemeziem Adanma; Nlemadim, Susan Ogechi; Chukwu, Blessing Ifeoma; Iwejuo, Sopuruchi Mary-Augusta; Amaechi, Onyedikachi Glory; Obiefuna, Victor Ifechukwu; Onuoha, Bessing Nmesomachi; Okoli, DivineTreasure Nzubechukwu; Nwokeoma, Precious Chinonso; Eze, Chukwubuikem
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.99-107

Abstract

Coffee leaves-based tea has relevance in ethno-medications due to its rich phyto-constituents-related diverse pharmacologic activities. Jonhu tisane, a typical Coffea arabica leaf decoction has no supporting scientific basis amidst reported location, processing and specie-related variations. This investigated physicochemical, antimicrobial, lethality and in-vitro antioxidant profiles of Johnu tisane by acceptable methods. Results recorded moisture (92.26 %), ash (0.65 %), unsaponified matter (1.46 mg/100 g), free fatty acid (0.56 mgKOH/g), acid value (1.12 mgKOH/g), potential hydrogen (6.85), lethal concentration (1000 ppm) and concentration-dependent antimicrobial activity. Anti-oxidation results revealed total antioxidant capacity, ferric reducing antioxidant power, nitric oxide, hydrogen peroxide and 2, 2-diphynyl-1-picrylhydrazyl scavenging activities increased concentration-dependently compared to standard. Thus, Johnu tisane demonstrated low minerals and keeping quality; requisite physicochemical mix for consumption and bioactivity; high safety margin; antimicrobial potency; and requisite anti-oxidation capacity for in-vivo antioxidant role. These provided scientific support for its ethno-medicinal uses. They underscored the need to elucidate its pharmacologically active compounds; mechanistic roles in animal models; and the impact of ash to moisture mix variation on potential hydrogen, microbial and antimicrobial activities in relation to shelf life, bioactivity and in vivo anti-oxidative roles for novel insights on preserving sample quality, safety, bioactivity and in-vivo anti-oxidative outcomes.
Therapeutic Azithromycin Mitigated Monosodium Glutamate-Related Dysfunction in Rats’ Body Weight and Serum, Liver, Kidney and Heart Antioxidant Defense Bioindicators Egbuonu, Anthony Cemaluk Chinedum; Alaebo, Prince Ogochukwu; Onuoha, Udumma Nsofor; Njoku, Chinomso Juliet; Eze, Obioma Benedeth; Odoemelam, Francisca Ugochi; Edum, Michael Eberechukwu; Obi, Ojichukwu Boniface; Ukaegbu, Mmesoma Joy; Nwaogwugwu, Sandra Uchechi; Orji, Marvellous Chinonso; Ndukwe, Clara Ngozika; Opara, Prosper; Oyoyo, Chinagorom; Joe-Eme, Chika Blessing; Okwoigwe, Cheluchiaka Jecinta
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.43-50

Abstract

Monosodium glutamate (MSG) mediates body weight gain (BWG) and oxidative stress. Azithromycin (AZT), may be abused and co-consumed with MSG to present unknown outcomes on BWG and oxidative stress. This study evaluated the effect of AZT and MSG in rats’ BWG and antioxidant bioindicators. Thirty rats assigned to five groups were orally exposed for seven consecutive days to groups A, control (distilled water, 1 ml/kg), B, MSG (MSG 8000 mg/kg), C, therapeutic AZT, TAZ (AZT 82.5 mg/kg), D, overdose AZT, OAZ (AZT 412.5 mg/kg) and E, TAZ + MSG (AZT 82.5 mg/kg + MSG 8000 mg/kg). MSG-treated rats exhibited a significantly (p < 0.05) increased BWG; serum, liver, kidney and heart reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and malondialdehyde (MDA) but decreased catalase (CAT) and zinc (Zn) levels compared to control. Co-treated TAZ + MSG rats significantly (p < 0.05) decreased BWG, GSH, GPX, SOD, Zn; increased CAT and non-significantly (p > 0.05) decreased MDA compared to MSG and control. Thus, TAZ significantly mitigated BWG, and malfunction in the metabolism of antioxidant defense bioindicators in MSG rats via probable anorexigenic, anti-inflammatory and antioxidant responses. This suggests that TAZ could be useful in managing MSG-related dysfunction in BWG and metabolic activity of the antioxidant defense apparatus in rats.
Co-Authors Alaebo, Prince Ogochukwu Amaechi, Onyedikachi Glory Chukwu, Blessing Ifeoma Edum, Michael Eberechukwu Egbuonu, Anthony Cemaluk Chinedum Eze, Chukwubuikem Eze, Obioma Benedeth Iwejuo, Sopuruchi Mary-Augusta Joe-Eme, Chika Blessing Ndukwe, Clara Ngozika Nlemadim, Susan Ogechi Nwaogwugwu, Sandra Uchechi Nwokeoma, Precious Chinonso Obi, Ojichukwu Boniface Obiefuna, Victor Ifechukwu Obike, Chiemeziem Adanma Odoemelam, Francisca Ugochi Okoli, DivineTreasure Nzubechukwu Okwoigwe, Cheluchiaka Jecinta Onuoha, Bessing Nmesomachi Onuoha, Udumma Nsofor Opara, Prosper Orji, Marvellous Chinonso Oyoyo, Chinagorom Ukaegbu, Mmesoma Joy