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All Journal Biology, Medicine, & Natural Product Chemistry
Iwejuo, Sopuruchi Mary-Augusta
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Physicochemical, Antimicrobial, Lethality and In Vitro Antioxidant Profiles of Johnu Tisane: A Coffee (Coffea Arabica) Leaf Decoction Formula Egbuonu, Anthony Cemaluk Chinedum; Alaebo, Prince Ogochukwu; Onuoha, Udumma Nsofor; Njoku, Chinomso Juliet; Obike, Chiemeziem Adanma; Nlemadim, Susan Ogechi; Chukwu, Blessing Ifeoma; Iwejuo, Sopuruchi Mary-Augusta; Amaechi, Onyedikachi Glory; Obiefuna, Victor Ifechukwu; Onuoha, Bessing Nmesomachi; Okoli, DivineTreasure Nzubechukwu; Nwokeoma, Precious Chinonso; Eze, Chukwubuikem
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.99-107

Abstract

Coffee leaves-based tea has relevance in ethno-medications due to its rich phyto-constituents-related diverse pharmacologic activities. Jonhu tisane, a typical Coffea arabica leaf decoction has no supporting scientific basis amidst reported location, processing and specie-related variations. This investigated physicochemical, antimicrobial, lethality and in-vitro antioxidant profiles of Johnu tisane by acceptable methods. Results recorded moisture (92.26 %), ash (0.65 %), unsaponified matter (1.46 mg/100 g), free fatty acid (0.56 mgKOH/g), acid value (1.12 mgKOH/g), potential hydrogen (6.85), lethal concentration (1000 ppm) and concentration-dependent antimicrobial activity. Anti-oxidation results revealed total antioxidant capacity, ferric reducing antioxidant power, nitric oxide, hydrogen peroxide and 2, 2-diphynyl-1-picrylhydrazyl scavenging activities increased concentration-dependently compared to standard. Thus, Johnu tisane demonstrated low minerals and keeping quality; requisite physicochemical mix for consumption and bioactivity; high safety margin; antimicrobial potency; and requisite anti-oxidation capacity for in-vivo antioxidant role. These provided scientific support for its ethno-medicinal uses. They underscored the need to elucidate its pharmacologically active compounds; mechanistic roles in animal models; and the impact of ash to moisture mix variation on potential hydrogen, microbial and antimicrobial activities in relation to shelf life, bioactivity and in vivo anti-oxidative roles for novel insights on preserving sample quality, safety, bioactivity and in-vivo anti-oxidative outcomes.
Co-Authors Alaebo, Prince Ogochukwu Amaechi, Onyedikachi Glory Chukwu, Blessing Ifeoma Egbuonu, Anthony Cemaluk Chinedum Eze, Chukwubuikem Njoku, Chinomso Juliet Nlemadim, Susan Ogechi Nwokeoma, Precious Chinonso Obiefuna, Victor Ifechukwu Obike, Chiemeziem Adanma Okoli, DivineTreasure Nzubechukwu Onuoha, Bessing Nmesomachi Onuoha, Udumma Nsofor