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All Journal Usadha Usadha Journal of Pharmacy
Yudianti Mendra, Ni Nyoman
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Formulasi Sediaan Shampo Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb) dan Daun Seledri (Apium graveolens L.) sebagai Antiketombe terhadap Jamur Candida albicans Danayasa, I Kadek; Yudianti Mendra, Ni Nyoman; Sunadi Putra, I Made Agus
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7382

Abstract

Dandruff is a scalp condition characterized by an anomaly, often caused by the fungus of Candida albicans. The development of safe and effective anti-dandruff shampoo is imperative. Notably, traditional medicine employs pandan wangi and celery leaves, rich in polyphenols, flavonoids, saponins, tannins and alkaloids as potential anti-dandruff agents. The aims of this study was to formulate and evaluate the antifungal activity of a combination shampoo containing extracts form pandan wangi and celery leaves. Antifungal testing was carried out using the diffusion method using paper discs. Three formulations were prepared FI (without extract), FII (10% pandan leaf extract, 20% celery leaf), FIII (20% pandan leaf extract, 10% celery leaf). Antifungal test was evaluated using the paper disc diffusion method, with 2% ketoconazole shampoo as the positive control. Physical quality test demonstrated favorable attributes for pandan wangi and celery leaf extract shampoo, with FII and FIII exhibiting dark green colors whit distinct odors, while FI remained colorless and odorless. Furthermore, all formulations were in semi-solid dosage forms and met pH requirement for scalps (pH 6,) and produced satisfactory foam yields (6,8-8,9 cm). The antifungal activity test revealed FI as the negative control with a 7 mm and 2% ketoconazole shampoo with a 24 mm inhibition zone, while FII and FIII showed no inhibition zone. The combination of pandan wangi and celery leaf extract in shampoo preparation showed no synergic activity to inhibit the growth of Candida albicans fungus. Further investigations and clinical trials are warranted to validate its effectiveness and safety for practical application.
EVALUASI DRUG RELATED PROBLEM (DRPs) PADA PASIEN DEMAM TIFOID DI INSTALASI RAWAT INAP RSU ISLAM KLATEN PERIODE NOVEMBER 2021-OKTOBER 2022 Marisya Affifah Putri, Nabilla; Fortuna, Tista Ayu; Yudianti Mendra, Ni Nyoman
Usadha Journal of Pharmacy Vol. 3 No. 2 (2024): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i2.318

Abstract

Demam tifoid adalah suatu penyakit yang disebabkan oleh infeksi organisme Salmonella typhi. Ketidaktepatan pemberian terapi pada pasien dapat meningkatkan resiko kejadian Drug Related Problems (DRPs). Tingginya kejadian (DRPs) dapat mempengaruhi keberhasilan terapi pada pasien, sehingga penelitian ini sangat penting untuk dilakukan. Tujuan penelitian ini adalah untuk mengetahui bagaimana tingkat kejadian DRPs yang meliputi kategori efek samping, interaksi pengobatan, dosis terlalu rendah serta dosis terlalu tinggi pada pasien demam tifoid di instalasi rawat inap periode November 2021-Oktober 2022. Penelitian ini merupakan penelitian non-eksperimental dengan pengambilan data secara retrospektif, dimana peneliti akan mengevaluasi pengobatan demam tifoid yang didapatkan oleh pasien. Pengambilan sampel dilakukan dengan teknik total sampling berdasarkan kriteria inklusi pasien meliputi usia lebih dari 18 tahun, pasien demam tifoid dengan atau tanpa penyakit penyerta dan pasien dengan rekam medis yang lengkap. Kiteria eksklusi meliputi pasien dengan data rekam medis yang tidak terbaca dan pasien dengan penyakit penyerta infeksi. Berdasarkan hasil penelitian terhadap 67 pasien, sebanyak 36 pasien (53,73%) mengalami DRPs dan 31 pasien (46,27%) tidak mengalami DRPs. Antibiotik yang paling banyak digunakan adalah levofloksasin 67 pasien (100%), kemudian diikuti dengan ampisilin 3 pasien (4,48%) serta sefiksim 3 pasien (4,48%). Penggunaaan terapi suportif yang paling banyak diberikan adalah parasetamol 67 pasien (100%). Jumlah DRPs yang terjadi sebanyak 65 kasus dengan rincian kategori dosis terlalu rendah 13 kasus (20%), dosis terlalu tinggi 2 kasus (3,08%), efek samping 14 kasus (21,54%), dan interaksi obat 36 kasus (55,38%).
Formulasi serta Evaluasi Aktivitas Antioksidan dan Tabir Surya Secara in Vitro Pada Krim Ekstrak Etanol Daun Sukun (Artocarpus altilis) Suradnyana, I Gede Made; Juli Widiarta, I Made; Yudianti Mendra, Ni Nyoman
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i2.12757

Abstract

Ultraviolet (UV) radiation exposure can cause various skin disorders, including sunburn, erythema, premature aging, wrinkles, pigmentation changes, and DNA damage, which may lead to photocarcinogenesis. Sunscreens play an important preventive role against these harmful effects, yet synthetic organic and inorganic agents may cause skin toxicity. Breadfruit (Artocarpus altilis) leaf extract contains phenolic compounds with dual photoprotective properties as antioxidants and UV filters. This study aimed to formulate and evaluate a sunscreen cream containing ethanol extract of breadfruit leaves. The formulation varied the concentrations of stearic acid and triethanolamine as emulsifiers. Physical properties (organoleptic, homogeneity, pH, adhesion, and spreadability) and in vitro activities (antioxidant by DPPH method and SPF by spectrophotometry) were assessed and compared with commercial creams. The results showed that the cream formulation containing 4% stearic acid and 2% triethanolamine exhibited the most ideal physical characteristics compared to commercial products. The breadfruit leaf ethanol extract cream demonstrated weak to moderate antioxidant activity, while at a concentration of 400 ppm, it exhibited sunscreen protection categorized as maximum protection. The ethanol extract of breadfruit leaves has the potential to be developed into a natural sunscreen formulation that is safe and environmentally friendly.
Co-Authors Danayasa, I Kadek Fortuna, Tista Ayu Juli Widiarta, I Made Marisya Affifah Putri, Nabilla Putra, I Made Agus Sunadi Suradnyana, I Gede Made