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All Journal CHEMPUBLISH JOURNAL Environmental and Materials
Raharto, Toto
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Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Energy Engineering Physics

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Synthesis of gold nanoparticles with allicin to modify boron-doped diamond surface for oxygen sensor applications Raharto, Toto; Setiyanto, Cahya Mukti; Ariyanta, Harits Atika; Nahda, Dinda Prastika Nabila; Hani, Adinda Muthia; Yulizar, Yoki; Ivandini, Tribidasari Anggraningrum; Einaga, Yasuaki
Environmental and Materials Vol. 1 No. 2: (December) 2023
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/eam.v1i2.2023.560

Abstract

Modification of surface of boron-doped diamond (BDD) film with gold nanoparticles (AuNPs) was carried out to increase its catalytic activity for an application as an oxygen sensor. Allicin was isolated from garlic by salting out extraction technique, and then used as the capping agent to synthesize AuNPs as it has a double bond structure that could be reacted to attach the BDD surface under UV light radiation. An average size of AuNPs at around 46,00 ± 9,06 nm was obtained, while the modification of the BDD surface by the synthesized AuNPs indicated that the surface of BDD could be covered by gold at around 0.6 % (w/w). Investigation of the AuNPs-modified BDD as a working electrode for the oxygen reduction by using cyclic voltammograms in 0.1 M phosphate buffer solution pH 7 observed a current peak at around -0.45 V (vs. Ag/AgCl). The current of this peak linearly increased proportionally to the dissolved oxygen concentrations (R2=0.9986). Moreover, a limit of detection of the dissolved oxygen of 0.12 ppm and limit of quantity 0.41 ppm could be achieved with excellent stability at 6.86% RSD with 6 repetitions and sensitivity at 19.086 μA/ppm indicated that the modified BDD is promising for applications as an oxygen sensor.
In silico and In vitro Study of The Anticancer Potential of Essential Oil from Sembung (Blumea balsamifera) Leaves against HeLa Cervical Cancer Cells Ulia, Rahmi Vika; Raharto, Toto; Suryati; Santoni, Adlis; Herru, Yoan De Nanda
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49160

Abstract

Blumea balsamifera (L.) DC. (sembung) is a medicinal plant widely recognized for its diverse pharmacological properties, including cytotoxic and anticancer activities. However, the anticancer potential of its leaf essential oil against cervical cancer remains poorly explored. This study aimed to evaluate the anticancer activity of B. balsamifera leaf essential oil against HeLa cervical cancer cells using integrated in silico and in vitro approaches. Molecular docking analysis against the anti-apoptotic Bcl-2 protein revealed favorable binding affinities for several major constituents, including camphor (-5.745 kcal/mol), caryophyllene (-7.077 kcal/mol), 7-epi-silphiperfol-5-ene (-7.311 kcal/mol), and γ-eudesmol (-7.083 kcal/mol), indicating potential interactions with apoptosis-related targets. Furthermore, cytotoxic activity assessed by the MTT assay demonstrated an IC₅₀ value of 32.90 µg/mL against HeLa cells, indicating moderate cytotoxic potency. These findings suggest that B. balsamifera leaf essential oil possesses promising anti-cervical cancer activity and may serve as a potential natural source for the development of apoptosis-targeting anticancer agents.
Co-Authors Adlis Santoni Einaga, Yasuaki Hani, Adinda Muthia Harits Atika Ariyanta Ivandini Tribidasari Anggraningrum Nahda, Dinda Prastika Nabila Rahmi Vika Ulia Setiyanto, Cahya Mukti Suryati Yoan De Nanda Herru Yoki Yulizar