Article Per Year (5 Year)
p-Index From 2021 - 2026
1.203
P-Index
This Author published in this journals
All Journal Jurnal Riset Kimia CHEMPUBLISH JOURNAL Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Molekul: Jurnal Ilmiah Kimia
Rahmi Vika Ulia
Department Of Chemistry, Faculty Of Science And Technology, Universitas Teknologi Nusantara, Bogor, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Komponen Kimia Minyak Atsiri yang Diisolasi dari Daun Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) dan Potensi Antibakteri serta Toksisitasnya Suryati; Thaharah Alifa Aziz Yenuuar; Shafinna Hana Fadhia; Rahmi Vika Ulia; Miftahul Melsya Salsabilla; Bustanul Arifin
Jurnal Riset Kimia Vol. 14 No. 1 (2023): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v14i1.583

Abstract

Pucuk merah (Syzygium myrtifolium Walp.) is an ornamental plant from the Myrtaceae family. Several phytochemical tests from previous researchers reported that pucuk merah contains secondary metabolites that have benefits such as antioxidants, antibacterials, and anti-cancer. In addition, the distinctive aroma produced from pucuk merah  leaves indicates the presence of essential oils whose bioactivity can be studied. Still, there has been no report on this plant's chemical components or bioactivity. Therefore, this study aims to determine the content of chemical components of pucuk merah  essential oil and their bioactivity as antibacterial and toxicity. The isolation of essential oils was carried out by the hydro distillation method. The chemical components of essential oils were analyzed using the Gas Chromatography-Mass Spectrometry (GC-MS) method. GC-MS results showed the presence of 42 compounds with four main compounds, namely caryophyllene (23.45%), 3-carene (15.67%), α-terpineol (10.74%), and α-pinene (5.98%) ). Antibacterial test of pucuk merah  essential oil using the disc diffusion method showed strong activity against Staphylococcus aureus and Escherichia coli with inhibition zones of 16.15 ± 2.03 and 16.13 ± 1.74 mm at 100% concentration. The results of the toxicity test of pucuk merah  essential oil using the BSLT (Brine Shrimp Lethality Test) method on Artemia salina Leach shrimp larvae showed strong toxic properties with an LC50 value of 3.99 µg/mL.
Cytotoxic Potential of Essential Oil Isolated from Clibadium Surinamese L Leaves Against T47D Breast and HeLa Cervical Cancer Cells Ulia, Rahmi Vika; suryati, Suryati; Santoni, Adlis
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.7816

Abstract

Semambu (C. surinamense L) plant is a shrub plant that is easy to find. Several terpenoid compounds have been isolated from this plant, previous studies have shown cytotoxic activity of terpenoid class compounds. Terpenoid compounds in a plant are mostly found in essential oils (monoterpenes and sesquiterpenes). So far, there has been no report on the cytotoxic potential of essential oils from the leaves of this plant. It is necessary to isolate the essential oils from C. surinamense L leaves and test their cytotoxic potential. Isolation of essential oil of C. surinamense L leaves was carried out by hydrodistillation method, the oil was obtained in the form of a light yellow liquid with a specific gravity of 0.968 g/mL. Analysis of chemical components with Gas Chromatography-Mass-Spectrometry (GC-MS) through comparison of data from the National Institute of Standards and Technologies (NIST) found that there were 55 compounds (monoterpene and sesquiterpene groups) with six main compounds, namely β-caryophyllene (30.4%), β-sesquiphellandrene (8.46%), 3 carene (8.16%), α-bisabolene (4.05%), α-humulene (4.0%), and epi- bicyclosesquiphellandrene (4.0%). The potential cytotoxic test of essential oil from isolation showed highly cytotoxic activity with the Brine Shrimp Lethality Test (BSLT) method against Artemia salina L shrimp larvae with LC50 value of 0.9261 μg/mL and Microculture tetrazolium test (MTT) method against T47D breast cancer cells and HeLa cervix with IC50 values of 12.72 μg/mL and 30.14 μg/mL.
Eksplorasi Aktivitas Antioksidan dan Profil Fenolik dari Ekstrak dan Fraksi Daun Lantana camara L Yoan De Nanda Herru; Adlis Santoni; Suryati Suryati; Anna Anggraini; Rahmi Vika Ulia
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5945

Abstract

This study aimed to evaluate the antioxidant activity and total phenolic content of methanolic extract and column chromatography fractions of Lantana camara L. leaves. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method, while total phenolic content was determined by the Folin–Ciocalteu assay. The methanolic extract exhibited strong antioxidant activity (IC₅₀ = 23.25 mg/L) and a total phenolic content of 2927.4 mg/L gallic acid equivalents (GAE). Fractionation yielded nine fractions (A–I), among which Fraction E demonstrated the highest antioxidant activity (IC₅₀ = 11.58 mg/L) and the greatest phenolic content (5200 mg/L GAE). A strong negative correlation (R² = 0.9485) was observed between phenolic content and IC₅₀ values, indicating that phenolic compounds are the major contributors to the antioxidant activity. These findings highlight L. camara leaves as a promising natural source of antioxidants and support their potential application in the development of functional foods and plant-based pharmaceutical formulations.
Cytotoxic Potential of Compounds Isolated from Non-Polar Fractions of Sungkai Plant Leaves (Peronema canescens Jack) Against Artemia salina Leach Larvae Suryati; Irfan Afrinal; Afrizal; Rahmi Vika Ulia
Jurnal Riset Kimia Vol. 15 No. 1 (2024): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i1.655

Abstract

The sungkai plant (Peronema canescens Jack), belonging to the Lamiaceae family, is a plant that is traditionally used as medicine, including toothache, malaria, and fever medicine. In this research, isolation was carried out with vacuum liquid chromatography (VLC), solid and liquid fractions were obtained. The solid fraction was further separated using column chromatography to obtain the isolated compound as a white solid (amorphous) weighing 10 mg (melting point 140˚C-142˚C). The results of the UV spectrum data show that there are no conjugated double bonds. The results of the IR spectrum show the presence of C-H groups at wave numbers 2921,49 cm-1 and 2856,94 cm-1, C=O groups at wave numbers, C=C groups at wave numbers 1641,51 cm-1, and dimethyl germinal which is characteristic of triterpenoid compounds at wave numbers 1456.68 cm-1 and 1372.41 cm-1. Meanwhile, the isolated oil was analyzed for chemical components using GC-MS. It was discovered that there were 83 chemical compound components contained therein with 4 main compound components, namely pentadecanoic acid (16.65%), 9,12-octadecanoic acid (16.12%), propyl palmitate (7.89%), and hexadecenoic acid, methyl ester (5.59%). A cytotoxic test was carried out on both fractions using the Brine Shrimp Lethality Test (BSLT) method. The results showed that the isolated compound was non-toxic with an LC50 value of 190214.2807 mg/L and the isolated oil was very toxic with an LC50 value of 34.2452 mg/L.
Exploration of Anticancer Activity Potential and Molecular Docking Study of Essential Oil Blumea balsamifera Leaves Against Several Breast Cancer Cell Lines (T47D and MCF-7) Rahmi Vika Ulia; Toto Raharto
Molekul Vol 21 No 2 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.2.17831

Abstract

ABSTRACT. The sembung plant (Blumea balsamifera) is a wild shrub traditionally used to treat various diseases, including cancer. However, comprehensive studies regarding the chemical composition, molecular docking interactions, and anticancer activity of its leaves essential oil against breast cancer cells are still limited. Therefore, this study aimed to explore the anticancer potential and molecular docking interactions of B. balsamifera leaves essential oil against estrogen receptor-positive breast cancer cell lines (T47D and MCF-7). The essential oil was isolated using hydrodistillation and analyzed using Gas Chromatography–Mass Spectrometry (GC-MS), which identified 36 chemical compounds. The major compounds were camphor (32.56%), caryophyllene (17.04%), 7-epi-silphiperfol-5-ene (5.33%), and gamma-eudesmol (5.01%). Preliminary cytotoxicity screening using the Brine Shrimp Lethality Test (BSLT) demonstrated strong cytotoxic activity with an LC50 value of 17.17 µg/mL. Molecular docking analysis against estrogen receptor alpha (ER-α) showed favorable binding affinity values ranging from -6.444 to -8.434 kcal/mol. Furthermore, the essential oil exhibited moderate anticancer activity against T47D and MCF-7 breast cancer cells, with IC50 values of 39.52 µg/mL and 30.18 µg/mL, respectively. These findings suggest that B. balsamifera leaves essential oil has potential as a natural source of anticancer compounds for further investigation. Keywords: Anticancer, Blumea balsamifera, molecular docking, MTT assay
In silico and In vitro Study of The Anticancer Potential of Essential Oil from Sembung (Blumea balsamifera) Leaves against HeLa Cervical Cancer Cells Ulia, Rahmi Vika; Raharto, Toto; Suryati; Santoni, Adlis; Herru, Yoan De Nanda
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49160

Abstract

Blumea balsamifera (L.) DC. (sembung) is a medicinal plant widely recognized for its diverse pharmacological properties, including cytotoxic and anticancer activities. However, the anticancer potential of its leaf essential oil against cervical cancer remains poorly explored. This study aimed to evaluate the anticancer activity of B. balsamifera leaf essential oil against HeLa cervical cancer cells using integrated in silico and in vitro approaches. Molecular docking analysis against the anti-apoptotic Bcl-2 protein revealed favorable binding affinities for several major constituents, including camphor (-5.745 kcal/mol), caryophyllene (-7.077 kcal/mol), 7-epi-silphiperfol-5-ene (-7.311 kcal/mol), and γ-eudesmol (-7.083 kcal/mol), indicating potential interactions with apoptosis-related targets. Furthermore, cytotoxic activity assessed by the MTT assay demonstrated an IC₅₀ value of 32.90 µg/mL against HeLa cells, indicating moderate cytotoxic potency. These findings suggest that B. balsamifera leaf essential oil possesses promising anti-cervical cancer activity and may serve as a potential natural source for the development of apoptosis-targeting anticancer agents.
Co-Authors Adlis Santoni Afrizal Anggraini, Anna Bustanul Arifin Irfan Afrinal Miftahul Melsya Salsabilla Raharto, Toto Shafinna Hana Fadhia Suryati Suryati Suryati Suryati Suryati Suryati Thaharah Alifa Aziz Yenuuar Toto Raharto Yoan De Nanda Herru Yoan De Nanda Herru