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All Journal Hydrogen: Jurnal Kependidikan Kimia International Journal of Global Operations Research Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP)
Handayani, Andi Ika Julianti
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Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

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Analgetic Effects of Kangkung (Ipomea reptans Poir) Extract on Swiss Webstesr Mice Handayani, Andi Ika Julianti; Hidayat, Saepul
International Journal of Global Operations Research Vol. 5 No. 1 (2024): International Journal of Global Operations Research (IJGOR), February 2024
Publisher : iora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47194/ijgor.v5i1.288

Abstract

One of the efficacious plants as an empirical analytic is kangkung (Ipomea reptans Poir). The purpose of this study was to determine the analgesic effect of kangkung and determine the dose of kangkung extract compared to ibuprofen. The benefit of this research is to know the analgesic effect of kangkung extract. The contents of extract kangkung are flavonoids. The research method of this experimental test is divided into 5 groups, each group consisting of 5 mice with weight 20-30 grams and age 2-3 months. Group 1 Negative control (Aquadest), group II Positive control (the suspension of ibuprofen), group III, IV, and V respectively were given the ground kangkung extract dose 6 mg/30 g, 12 mg/30 g, 24 mg/30 g. The treatment is administered orally, and for the introduction of the induction using acetic acid 0.5% dose 0.2 ml/20 g mice are intraperitonial. The result of analyzed by Test homogeneity followed by a Variant analyze Test (ANOVA) one way with SPSS for window version 16. The homogenized results of the research of extract kangkung land extract (P = 0.24), a one-way test is obtained significant result 0.00, the dose I, II, III differs significantly with negative and positive control. Conclusion of the ground Kangkung extract has an analytic effect by lowering the amount of stretched. The results showed at a dose of 28 mg/30 g mice caused the best analytic effect among the variations of the dose tested.
Optimization of Extraction Parameters for Phenolics and Flavonoids from Peony (Paeonia lactiflora) Flowers Using Ultrasound-Assisted Extraction Jasmin, Faida; Handayani, Andi Ika Julianti; Akmal, Tubagus
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14346

Abstract

Peony (Paeonia lactiflora) flowers, celebrated for their aesthetic and bioactive attributes, possess potential as natural antioxidant sources owing to their elevated phenolic and flavonoid concentrations. This study employed ultrasound-assisted extraction (UAE) and response surface methodology (RSM) to optimize the extraction parameters for phenolic and flavonoid compounds. The Box-Behnken Design using method Ultrasoud Assisted Extraction determined the optimal extraction parameters of Paeonia lactiflora flowers to be 49% ethanol concentration, a liquid-to-solid ratio of 50 mL/g, and an extraction time of 22 minutes. The parameters yielded a total phenolic content (TPC) of 205.463 mg GAE/g DW and a total flavonoid content (TFC) of 95.465 mg QE/g DW. The results underscore the significance of the liquid-to-solid ratio as a critical factor in extraction efficiency, while ethanol concentration and extraction duration exhibited considerable interactive effects. The findings confirm the efficacy of UAE as a sustainable and efficient technique for extracting bioactive components from Paeonia lactiflora, indicating its potential use in pharmaceuticals and nutraceuticals. Future research should explore the antioxidant activity and IC50 values of these extracts for expanded therapeutic use.
Optimization of Extraction Parameters for Phenolics and Flavonoids from Peony (Paeonia lactiflora) Flowers Using Ultrasound-Assisted Extraction Jasmin, Faida; Handayani, Andi Ika Julianti; Akmal, Tubagus
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14346

Abstract

Peony (Paeonia lactiflora) flowers, celebrated for their aesthetic and bioactive attributes, possess potential as natural antioxidant sources owing to their elevated phenolic and flavonoid concentrations. This study employed ultrasound-assisted extraction (UAE) and response surface methodology (RSM) to optimize the extraction parameters for phenolic and flavonoid compounds. The Box-Behnken Design using method Ultrasoud Assisted Extraction determined the optimal extraction parameters of Paeonia lactiflora flowers to be 49% ethanol concentration, a liquid-to-solid ratio of 50 mL/g, and an extraction time of 22 minutes. The parameters yielded a total phenolic content (TPC) of 205.463 mg GAE/g DW and a total flavonoid content (TFC) of 95.465 mg QE/g DW. The results underscore the significance of the liquid-to-solid ratio as a critical factor in extraction efficiency, while ethanol concentration and extraction duration exhibited considerable interactive effects. The findings confirm the efficacy of UAE as a sustainable and efficient technique for extracting bioactive components from Paeonia lactiflora, indicating its potential use in pharmaceuticals and nutraceuticals. Future research should explore the antioxidant activity and IC50 values of these extracts for expanded therapeutic use.
Perbandingan Pelarut Terhadap Jumlah Rendemen Ekstrak Daun Singkong (Manihot utilissima Pohl) Menggunakan Metode Soxhletasi Handayani, Andi Ika Julianti; Pertiwi, Dwi Chyntia
Pharmaceutical Science and Clinical Pharmacy Vol 1 No 1 (2023)
Publisher : Akademi Farmasi Bumi Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61329/pscp.v1i1.4

Abstract

Tumbuhan daun singkong merupakan tumbuhan obat yang digunakan secara turun-temurun, salah satunya dapat mengobati rematik, asam urat, anemia, konstipasi, serta untuk meningkatkan daya tahan tubuh. Tujuan dari penelitian ini yaitu untuk mengetahui hasil rendemen yang diperoleh dari ekstrak daun singkong (Manihot utilissima Pohl) dengan pelarut yang berbeda dan juga untuk mengetahui pelarut manakah yang menghasilkan rendemen yang paling banyak dari metode ekstraksi soxhletasi daun singkong. Hasil penelitian menunjukan bahwa hasil rendemen ekstrak daun singkong pada pelarut aquadest yaitu 0,26%, pada pelarut etil asetat yaitu 0,16%, dan pada pelarut n-heksan yaitu 0,07%. Dengan ini, hasil rendemen yang paling besar yaitu menggunakan pelarut aquadest.
Co-Authors Akmal, Tubagus Hidayat, Saepul Jasmin, Faida Pertiwi, Dwi Chyntia