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All Journal JURNAL KAJIAN VETERINER Jurnal Veteriner Nusantara
Darang, Calvin Lummu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Gambaran Hematologi dari Pemberian Anestesi Kombinasi Ketamin-Xilazin dan Ketamin-Diazepam pada Pelaksanaan Kastrasi Anjing Utami, Tri; Tophianong, Tarsisius Considus; Semarabawa, I Gede; Darang, Calvin Lummu
JURNAL KAJIAN VETERINER Vol 12 No 1 (2024): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v12i1.15221

Abstract

Carrying out castration on dogs requires anesthesia to prevent movement and relieve pain during the operation. The aim of this study was to determine the effect of administering two combinations of general anesthesia, ketamine - xylazine and ketamine-diazepam on the blood features of dogs undergoing castration procedures. The dogs used in this study were 6 dogs, domestic breed, male and aged between six months and one year. Blood sampling from the cephalic antebrachii vein of 1 ml was carried out twice, thirty minutes before surgery and sixty minutes after surgery. The average results of post-operative complete blood tests in dogs given ketamine (10 mg/kg body weight, iv) – xylazine (1 mg/kg body weight, iv) anesthesia, include: total erythrocyte count 5.84 x 106/µL, haemoglobin 12.27 g/dL, haematocrit 36.7%, and leukocytes 15.4 x 103/µL. The average results of post-operative complete blood tests in dogs given ketamine (10 mg/kg body weight, iv)–diazepam (0.2 mg/kg body wight, iv) anesthesia, include: total erythrocyte count 5.98 x 106/µL, haemoglobin 11.77 g/dL, haematocrit 36.23%, and leukocytes 16.4 x 103/µL. Based on the results of statistical analysis using the independent t-test, the number of erythrocytes, haemoglobin, haematocrit and post-operative leukocytes between the two groups was not significantly different (P>0.05). The use of the combination of ketamine-xylazine and ketamine - diazepam during castration did not cause changes in the number of erythrocytes, haemoglobin, haematocrit and leukocytes.
The Effect of Ketamine-Zolazepam-Tiletamine and Ketamine-Diazepam Anesthesia Combination on Physiological Features of Dog Castration (Canis Familiaris) Darang, Calvin Lummu; Utami, Tri; Tophianong, Tarsisius Considus
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.26740

Abstract

Castration in male dogs is a medical procedure aimed at reducing the population of male dogs. The purpose of this study was to determine the physiological profile of administering a combination of ketamine-zolazepam-tiletamine and ketamine-diazepam during castration. Six domestic male dogs weighing 8-15 kg and aged 6 months to 1 year were used in this study. Physiological observations of heart rate, respiratory rate, body temperature, digit reflex, and pupil reflex were statistically analyzed using an independent t-test. The oral mucosa was observed descriptively. Statistical analysis results showed that heart rate in group K1 with ketamine administration (10 mg/kg bw, iv) – zolazepam-tiletamine (5 mg/kg bw, iv) and K2 with ketamine (10 mg/kg bw, iv) and diazepam (0.2 mg/kg bw, iv) from T0 to T60 showed significant differences (P<0.05). Respiratory rates in groups K1 and K2 at T0, T10, T40, T50, and T60 showed significant differences. Body temperature and pupillary reflexes in groups K1 and K2 showed no significant differences. Dog digit reflexes in groups K1 and K2 showed significant differences. The combination of ketamine-zolazepam-tiletamine (KZT) and ketamine-diazepam (KD) caused an increase in heart rate and respiratory rate from normal values, but the increase in KD was closer to normal limits. Body temperature was within normal limits when KZT and KD combinations were administered. The loss of digit reflex and pupil reflex responses with the KZT combination lasted longer than with KD, indicating that the analgesia and sedation quality of KZT was deeper than that of KD. The oral mucosa in the KZT and KD combinations was pink, and the Capillary Refill Time (CRT) was < 2 seconds from T0 to T60.
Co-Authors Semarabawa, I Gede Tarsisius Considus Tophianong, Tarsisius Considus Tri Utami