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Arifin, Dani Fajar
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Pengaruh Ozonated Olive Oil terhadap Jumlah Osteoblas pada Gingiva Tikus Wistar Jantan yang Mengalami Periodontitis Anwaristi, Aprilia Yuanita; Arifin, Dani Fajar
Health & Medical Sciences Vol. 1 No. 1 (2023): November
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v1i1.64

Abstract

Latar Belakang: Periodontitis disebabkan adanya penumpukan bakteri plak pada permukaan gigi. Pengobatan pada penyakit periodontitis secara mekanis juga harus menggunakan pengobatan kimiawi lokal yang diutamakan dibanding pengobatan sistemik seperti antibiotik. Ozonated olive oil sebagai terapi tambahan tidak menimbulkan rasa sakit dan dapat digunakan sebagai antiseptik dalam perawatan non-bedah penyakit periodontal. Ozon juga memiliki spektrum aktivitas yang luas tetapi dengan toksisitas rendah, memberikan keuntungan pada perawatan lokal ini sebelum pengembangan zat dengan aksi yang lebih spesifik pada mikro- organisme yang terkait dengan periodontitis. Metode: Penelitian ini merupakan jenis penelitian true experimental laboratorium dengan rancangan penelitian Posttest-Only Control Group dan terdapat dua kelompok kontrol yaitu, kelompok kontrol dan kelompok perlakuan. sampel terdiri atas 24 tikus wistar jantan diinkubasi periodontitis dibagi menjadi 2 kelompok berdasarkan hari, kelompok kontrol dan kelompok perlakuan. sampel dianalisis secara histologis pada hari ke- 7 dan 14. Hasil: Hasil uji hipotesis menemukan bahwa nilai signifikansi p 0,00 (p<0,05), hasil tersebut menunjukkan bahwa terdapat perbedaan yang signifikan jumlah sel osteoblas antara kelompok perlakuan ozonated olive oil dengan kelompok kontrol. Hasil Uji Post Hoc LSD menunjukkan bahwa kelompok perlakuan memiliki perbedaan bermakna antara kelompok kontrol dan perlakuan memiliki tingkat signifikansi (p<0,05). Kesimpulan: Penelitian yang telah dilakukan menghasilkan kesimpulan bahwa pemberian ozonated olive oil dapat mempengaruhi jumlah sel osteoblas berperan dalam proses penyembuhan periodontitis pada tikus putih (rattus novergicus) galur wistar jantan.
the effect of ozonated olive oil on the number of neutrophil cells in the gingiva of male Wistar rats experiencing periodontitis (in vivo) Anwaristi, Aprilia Yuanita; Cahyani, Cahyani; Faizah, Ariyani; Fauziyah, Nida Faradisa; Arifin, Dani Fajar; Hidayanti, Nur; Lestari, Cindy
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.21-29

Abstract

Background: Periodontal tissue, comprising gingiva, periodontal ligament, cementum, and alveolar bone, supports and surrounds teeth. Periodontitis, an inflammation affecting these tissues, manifests through gingival inflammation, pocket formation, and loss of attachment and bone.Purpose: This research aims to investigate whether ozonated olive oil influences neutrophil cell levels in the gingiva of male Wistar rats with periodontitis.Method: Employing a posttest-only control group design, this laboratory study included 24 male Wistar rats with concentrated periodontitis divided into six groups based on the day of observation. Histological analysis was conducted on days 1, 3, and 5, with three control groups and treatment groups.Result: The hypothesis test revealed a significant difference in neutrophil cell count between the ozonated olive oil treatment group and the control group (p < 0.05). The treatment group exhibited superior outcomes compared to control and other treatment groups, as confirmed by the LSD Post Hoc Test (p < 0.05).Conclusion: Administration of ozonated olive oil can influence neutrophil cell involvement in periodontitis healing among male Wistar rats, suggesting its potential therapeutic efficacy
the effect of ozonated olive oil on the number of neutrophil cells in the gingiva of male Wistar rats experiencing periodontitis (in vivo) Anwaristi, Aprilia Yuanita; Cahyani, Cahyani; Faizah, Ariyani; Fauziyah, Nida Faradisa; Arifin, Dani Fajar; Hidayanti, Nur; Lestari, Cindy
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.21-29

Abstract

Background: Periodontal tissue, comprising gingiva, periodontal ligament, cementum, and alveolar bone, supports and surrounds teeth. Periodontitis, an inflammation affecting these tissues, manifests through gingival inflammation, pocket formation, and loss of attachment and bone.Purpose: This research aims to investigate whether ozonated olive oil influences neutrophil cell levels in the gingiva of male Wistar rats with periodontitis.Method: Employing a posttest-only control group design, this laboratory study included 24 male Wistar rats with concentrated periodontitis divided into six groups based on the day of observation. Histological analysis was conducted on days 1, 3, and 5, with three control groups and treatment groups.Result: The hypothesis test revealed a significant difference in neutrophil cell count between the ozonated olive oil treatment group and the control group (p < 0.05). The treatment group exhibited superior outcomes compared to control and other treatment groups, as confirmed by the LSD Post Hoc Test (p < 0.05).Conclusion: Administration of ozonated olive oil can influence neutrophil cell involvement in periodontitis healing among male Wistar rats, suggesting its potential therapeutic efficacy
Co-Authors Anwaristi, Aprilia Yuanita Aprilia Yuanita Anwaristi Ariyani Faizah Cahyani Cahyani Hidayanti, Nur Lestari, Cindy Nida Faradisa Fauziyah