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All Journal Stannum : Jurnal Sains dan Terapan Kimia IJIS Edu : Indonesian Journal of Integrated Science Education
Harianto, Bibit
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Education Social Sciences Other

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Analysis of Students Chemical Literacy through Ethnochemistry Learning in Material Colligative Properties of Solution Harianto, Bibit; Pursitasari, Indarini Dwi; Heliawati, Leny
IJIS Edu : Indonesian Journal of Integrated Science Education Vol 7, No 1 (2025): January 2025
Publisher : UIN Fatmawati Sukarno Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/ijisedu.v7i1.5000

Abstract

The industrial revolution in the 21st century demands the creation of a generation that is responsive to change and has the competencies of Critical Thinking, Creative Thinking, Communication, and Collaboration (4C). The contextual learning process based on ethnochemistry is expected to increase students' motivation and interest in learning chemistry. Chemistry subjects that are classified as difficult and can be linked to local culture are the colligative properties of solutions. This study aims to analyze chemical literacy through learning with an Ethnochemical approach to the material of colligative properties of solutions. The research method used is quantitative descriptive research. Data collection using a test method, the test method is in the form of multiple-choice chemical literacy questions with a total of 10 validated questions and has a reliability index in the moderate category. The test method aims to determine students' chemical literacy in terms of content, context, and competence. The results of the study showed that the average chemical literacy of students in terms of content aspects was 49.2%; context aspects of 40.4%, and competency aspects of 50.6%. Th e average chemical literacy from these three aspects is categorized as “Not Enough”. The results of the study concluded that chemical literacy in ethnochemistry-based learning is in the “Not Enaough” category. The recommendation from this study is the need for innovation in chemistry learning through integration between ethnochemistry and STEM as well as the development of teaching materials in the form of ethnochemistry-based books that support the learning process.
Phytochemical Analysis and Study of Molecular Docking of Leucaena leucocephala Leave Extract as Anticancer Ariefin, Mokhamat; syarpin, Syarpin; Harianto, Bibit
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4387

Abstract

Cancer is a disease caused by unnatural cell growth in the body. It has become a disease with a high mortality rate in the world. Several therapies have been developed for cancer treatment, one of which is the exploration of the bioactivity of compounds contained in potentially medicinal plants. One of the potential medicinal plants that grows in Central Kalimantan province is L. leucocephala. In this study, the potential of L. leucocephala leaf extract was explored through phytochemical tests and molecular docking approaches. Based on the phytochemical test, it was found that L. leucocephala leaf extract contains flavonoids, terpenoids, and steroids. Based on the test results, a literature study was conducted on the flavonoids and terpenoids content in L. leucocepala leaf extract and molecular docking studies were conducted. Seven dominant compounds of L. leucocephala consisting of flavonoids and terpenoids were tested for their potential as inhibitors of receptor tyrosine kinase. The molecular docking results showed that flavonoid ligands (1-6) had more negative binding affinity values compared to the drug sunitinib, a common drug for cancer therapy, while terpenoid ligand (7) had less favorable binding energy. Based on the Lipinski rule of five test, ligands 1, 2, 4, and 5 fulfill all the criteria given as drug candidates, while ligands 3, 6, and 7 only fulfill 3 out of 5 criteria. Based on Lipinski rule of five and molecular docking, ligand 1,2,4, and 5 has potential to be anticancer.
Co-Authors Indarini Dwi Pursitasari Leny Heliawati Mokhamat Ariefin syarpin, syarpin