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All Journal Stannum : Jurnal Sains dan Terapan Kimia Journal of Innovation in Educational and Cultural Research
Harianto, Bibit
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education

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Phytochemical Analysis and Study of Molecular Docking of Leucaena leucocephala Leave Extract as Anticancer Ariefin, Mokhamat; syarpin, Syarpin; Harianto, Bibit
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4387

Abstract

Cancer is a disease caused by unnatural cell growth in the body. It has become a disease with a high mortality rate in the world. Several therapies have been developed for cancer treatment, one of which is the exploration of the bioactivity of compounds contained in potentially medicinal plants. One of the potential medicinal plants that grows in Central Kalimantan province is L. leucocephala. In this study, the potential of L. leucocephala leaf extract was explored through phytochemical tests and molecular docking approaches. Based on the phytochemical test, it was found that L. leucocephala leaf extract contains flavonoids, terpenoids, and steroids. Based on the test results, a literature study was conducted on the flavonoids and terpenoids content in L. leucocepala leaf extract and molecular docking studies were conducted. Seven dominant compounds of L. leucocephala consisting of flavonoids and terpenoids were tested for their potential as inhibitors of receptor tyrosine kinase. The molecular docking results showed that flavonoid ligands (1-6) had more negative binding affinity values compared to the drug sunitinib, a common drug for cancer therapy, while terpenoid ligand (7) had less favorable binding energy. Based on the Lipinski rule of five test, ligands 1, 2, 4, and 5 fulfill all the criteria given as drug candidates, while ligands 3, 6, and 7 only fulfill 3 out of 5 criteria. Based on Lipinski rule of five and molecular docking, ligand 1,2,4, and 5 has potential to be anticancer.
Ethno-STEM-Based E-Book on Colligative Properties of Solutions to Improve Students' Chemical Literacy and Sustainability Awareness Harianto, Bibit; Pursitasari, Indarini Dwi; Heliawati, Leny; Syarpin, Syarpin
Journal of Innovation in Educational and Cultural Research Vol 7, No 2 (2026): Article in Press
Publisher : Yayasan Keluarga Guru Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46843/jiecr.v7i2.2565

Abstract

This project aims to develop and test Ethno-STEM-based e-books to enhance students’ chemical literacy and sustainability awareness regarding the colligative properties of solutions. The e-book’s development integrates coordination science with local knowledge, enabling students to understand chemical concepts in a relevant and applicable manner. The research strategy employed is RD using the ADDIE model. The e-book was approved by media and content specialists and tested on students to assess its effectiveness in improving chemical education and sustainability awareness. The level of feasibility based on media expert judgment is 89% in the "Valid" category, and media experts are 95% in the "Valid" category. Also, the CVR value is 0.86 and the CVI is 0.93, both of which are in the valid range. E-Books improve students' chemical literacy and sustainability awareness, with N-Gain indices of 0.745 in the "high" category and 0.541 in the "moderate" category—long-term impacts and applications to other disciplines are to be studied to support ESD programs.
Co-Authors Indarini Dwi Pursitasari Leny Heliawati Mokhamat Ariefin syarpin, syarpin