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Alasen Sembiring Milala
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Sistem Penghantaran Obat dengan Misel Polimer Alasen Sembiring Milala
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.104

Abstract

Today is the era of nanotechnology, where almost all fields use nanotechnology. Likewise, the field of pharmaceutical technology is currently intensively developing pharmaceutical preparations using nanosystem. One of these nanosystems is polymeric micelles, which generally have particle size below 100 nm. Research showed that polymeric micelles have been proven to increase the solubility and bioavailability of hydrophobic drugs. There are several methods that can be used in polymeric micelles preparation, each of which has advantages and disadvantages. In order to characterize polymer micelles, parameter evaluation includes determination of critical micelle concentration (CMC), particle size, surface characteristics, stability, and release tests. Although most of the research on polymer micelles was applied in the field of oncology by the intravenous route of administration, researchers are currently developing drug delivery system using polymer micelles for oral route of administration. It can be further expected to initiate clinical research like such that has been done on intravenous administration.
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