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All Journal MEDICINUS Pharmacon: Jurnal Farmasi Indonesia
Dara Ugi Aras
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Potensi farmakologi Kasumba Turatea (Carthamus tinctorius L.) sebagai antibakteri Lismayana Hansur; Ami Febriza; Dito Anurogo; Dara Ugi Aras; Endah Dwijayanti
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6zstjd88

Abstract

Kasumba turatea (Carthamus tinctorius L.) is a plant that has been used as traditional medicine in South Sulawesi. Themain component of C. tinctorius L. flowers is hydroxysafflor yellow A, which functions as an anti-inflammatory, antioxidant,and platelet aggregation inhibitor. This review highlights pharmacological potential of C. tinctorius L. as an antibacterialagent. The method involves a literature review from various databases such as PubMed, Google Scholar, and Scopus. Theresults show that C. tinctorius L. extracts are effective against various pathogenic bacteria such as Listeria monocytogenes,Streptococcus iniae, Staphylococcus aureus, and Escherichia coli. Bioactive compounds like carthamin, phenolics, and flavonoids exhibit significant antibacterial activity. Additionally, C. tinctorius L. extracts also show potential as anthelminticand antioxidant agents. Further research is required to isolate and characterize specific bioactive compounds, followed by in vivo validation and clinical study to confirm their efficacy as well as safety. 
Potential of Hydroxysafflor yellow A, the main compound of Kasumba Turate (Carthamus tinctorius ) as Anti-Inflammatory in Lung, Liver and Cardiac Tissues: A Literature Review Lismayana Hansur; Dara Ugi Aras; Endah Dwijayanti
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.4908

Abstract

Inflammation is the body's physiological response to stimuli such as infection, trauma and chronic disease. Its exacerbation can lead to deterioration in health and damage to tissues in organs such as the lungs, kidneys and liver. The drive behind the development of anti-inflammatory drugs is to improve treatment efficacy and reduce adverse effects. The primary aim of this article is to deliberate on the pharmacological properties of compound from C.tinctorius as an anti-inflammatory agent. Through an extensive study of data we made a literature review of 17 research conducted to unravel the potential of compound from C.tinctorius as an anti-inflammatory agent. The ability of Carthamus tinctorius to alleviate inflammation is demonstrated by its ability to inhibit the activation of the NF-κB pathway and suppress the binding of the TGF-β1 promoter. These molecular processes hold the promise of ameliorating lung injury by attenuating the inflammatory response through suppression of the TLR 4-dependent signalling pathway, thereby improving the health of rats suffering from pulmonary fibrosis, a condition characterised by inflammation and vascular tissue repair. In addition, compounds in C. tinctorius are effective in reducing T lymphocyte (CD4) apoptosis in sepsis through their anti-inflammatory and anti-apoptotic effects. The anti-inflammatory mechanism is also demonstrated by reducing inflammatory cytokines such as IL-6 in the lungs, kidneys and liver.
Co-Authors Ami Febriza Dito Anurogo Endah Dwijayanti Endah Dwijayanti Lismayana Hansur Lismayana hansur