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All Journal Alchemy : Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kefarmasian Indonesia
Tauladani, Saeful Akhmad
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Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Prakoso, Arthur Hariyanto; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Nugraha, Ari Satia
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial indohoki77 juga dikenal karena layanan pelanggannya yang responsif dan profesional. Tim dukungan pelanggan tersedia 24/7 untuk membantu para pemain dengan segala pertanyaan atau masalah yang mereka hadapi screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 
Isolasi dan Skrining Aktivitas Antibakteri Fungi Tanah Muara Desa Katialada Gorontalo Lokasi Satu terhadap Staphylococcus aureus Rohmatillah, Wilda Nur; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Pratoko, Dwi Koko; Nugraha, Ari Satia
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5978

Abstract

The emergence of antibiotic resistance becomes a barrier in controlling infectious diseases, so it is necessary to find new alternative antibiotics. This study aimed to explore the potential of estuarine soil fungals secondary metabolites isolated from Katialada Village Gorontalo Location One and test their antibacterial activity against Staphylococcus aureus. The antibacterial parameter observed was the percent inhibition of ethyl acetate extracts against Staphylococcus aureus. The estuarine soil samples were cultured in PDA media producing five single fungal isolates differentiated based on color morphology, texture, and shape coded IS2-BTG-4.1.1, IS2-BTG-4.1.2, IS1-BTG-4.2, IS2-BTG4.3.1, and IS2-BTG-4.3.2. Those five samples were fermented using PDB media and the fermented products were extracted with ethyl acetate. The extracts were screened for its compound using a TLC plate and antibacterial testing with a single concentration of 100 g/mL in the microdilution method. The screening results showed that the five ethyl acetate extracts contained terpenoid compounds and code IS2-BTG-4.3.2 also had alkaloids. Based on the antibacterial test results, the five ethyl acetate extracts had growth inhibitory activity on the Staphylococcus aureus, with the percentage showed by IS2-BTG-4.1.1 50,2% ± 14,8%, IS2-BTG-4.1.2 35,6% ± 12,9%, IS1-BTG-4.2 13,0% ± 7,3%, IS2-BTG-4.3.1 13,6% ± 6,0%, and IS2-BTG-4.3.2 by 12,4% ± 9,2%.
Isolasi Fungi Tanah Muara Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Staphylococcus aureus Zanuba, Nafa Rosyida; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharram, Gani Asri; Asia, Asia; Triatmoko, Bawon; Wulandari, Lestyo; Nugraha, Ari Satia
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.91460

Abstract

Penyalahgunaan antibiotik sebagai agen terapi pada infeksi dapat memberikan ancaman resistensi antibiotik yang mengakibatkan efektifitas pengobatan menjadi kurang optimal. Untuk mengatasi persoalan tersebut, banyak penelitian dilakukan untuk mencari agen antibakteri baru dari bahan alam seperti fungi tanah sebagai pengujian antibakteri. Penelitian ini bertujuan untuk mengetahui potensi antibakteri dari metabolit sekunder fungi tanah terhadap bakteri Staphylococcus aureus yang ditunjukkan melalui nilai persen penghambatan. Penelitian ini menggunakan metode mikrodilusi untuk mngetahui besaran aktivitas antibakteri pada sampel fungi tanah. Fungi tanah didapatkan dari sampel tanah yang diambil dari desa Katialada, Gorontalo dengan kode lokasi BTG-6 dan dikultur pada media PDA dan diisolasi pada media PDA baru hingga didapatkan 11 isolat tunggal. Skrining awal aktivitas antibakteri dilakukan dengan metode uji antagonis pada 11 isolat dengan hasil enam isolat diantaraya memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Keenam isolat tersebut akan dilakukan fermentasi dan ekstraksi menggunakan etil asetat untuk mendapatkan ekstrak yang akan digunakan pada pengujian antibakteri menggunakan metode mikrodilusi. Hasil pengujian menunjukkan keenam isolat memiliki aktivitas antibakteri terhadap bakteri uji dan direpresentasikan melalui persen penghambatan pada masing-masing isolat sebesar IS2-BTG6- 1-1 sebesar 34,6 ± 2,4%; IS3-BTG6-1-3-2 sebesar 42,8 ± 3,1%; IS2-BTG6-3-3 sebesar 41,1 ± 4,4%; IS3-BTG6-1-2-1 sebesar 41,8 ± 2,9%; IS3-BTG6-1-2-2 sebesar 47,8 ± 2,6%; IS2-BTG6- 3-3 sebesar 59,2 ± 4,8%.
Co-Authors Ari Satia Nugraha Asia, Asia Bawon Triatmoko Lestyo Wulandari Muhammad Zainul Arifin Muharam, Gani Asri Muharram, Gani Asri Prakoso, Arthur Hariyanto Rohmatillah, Wilda Nur Zanuba, Nafa Rosyida