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Ray, Jassaswi
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Medicine & Pharmacology

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EVALUATION OF THE ANTIEPILEPTIC EFFECT OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODEL USING MAXIMAL ELECTROSHOCK SEIZURE (MES) Sahoo, Snehalata; Ray, Jassaswi; Prusty, Shaktiketan; Mohanty, R.
Journal of Global Pharma Technology Volume 16 Issue 09 (2024) September 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Epilepsy, a neurological disorder characterized by recurrent seizures, poses significant challenges to affected individuals due to its diverse etiology and limited therapeutic options. This thesis explores the potential therapeutic efficacy of ethanolic extracts derived from Cassia tora leaves in managing epilepsy. Through preclinical investigations, the study aims to elucidate the pharmacological mechanisms underlying the antiepileptic properties of Cassia tora, shedding light on its viability as a complementary or alternative therapy for epilepsy management. Experimental methodologies include in vitro assays to assess neuroprotective effects, in vivo animal models to evaluate seizure severity and frequency, as well as biochemical analyses to elucidate the extract's impact on neurotransmitter systems and oxidative stress pathways. Results from this research endeavor contribute valuable insights into the development of novel therapeutic interventions for epilepsy, potentially enriching the existing armamentarium of antiepileptic drugs and enhancing patient outcomes. Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions worldwide. Current pharmacological treatments often have limitations, prompting exploration into alternative therapies such as herbal extracts. Cassia tora, known for its medicinal properties, is hypothesized to possess antiepileptic effects. This thesis investigates the potential of Cassia tora ethanolic leaf extract in mitigating seizures induced by maximal electroshock (MES) in animal models. Keywords: Cassia tora (C.T), Chrysophanol, Emodin, Anthraquinones, Rat.
RECENT DRUG DISCOVERY STATUS AGAINST PEPTIC ULCER Panda, Girija Shankar; Sahoo, Deeptitapa; Ray, Jassaswi; Mohanty, R.; Nayak, Ritesh Kumar
Journal of Global Pharma Technology Volume 16 Issue 10 (2024) October 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Peptic ulcer is a customary disease, it affecting around 5-10% of the general population worldwide, but with notable regional and rectal variants. The two most common etiological causes are the chronic infection with Helicobacter Pylori (HP) and the uses of nonsteroidal anti-inflammatory drugs (NSAIDS). Its diagnosis is based mainly in the endoscopy and the active search of contaminant Helicobacter pylori presence. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid, pepsin, refluxed bile, leukotrienes, relative oxygen species and defensive factors, which include the function of the mucus, bicarbonate barrier, prostaglandins, mucosal blood flow, cell renewal and migration, non-enzymatic and enzymatic antioxidants and some growth factors. Keywords: Helicobacter Pylori, NSAID, Proton Pump Inhibiter, Leukotriene, Bicarbonate Barrier, Refluxed Bile.
EXPLORING THE ANTI-PARKINSONIAN POTENTIAL OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODELS Mishra, Bandana; Ray, Jassaswi; Prusty, S.K.; Mohanty, Rajashree; Patra, Anup Ku
Journal of Global Pharma Technology Volume 16 Issue 11 (2024) November 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments resulting from the loss of dopaminergic neurons. Current treatments provide symptomatic relief but do not halt disease progression. In this study, we investigated the potential therapeutic effects of Cassia tora ethanolic leaves extract (CTELE) on PD using animal models. CTELE, known for its rich bioactive compounds, was administered orally to PD-induced animals, and their behavioral responses were assessed using standard motor function tests. Additionally, histopathological examination and biochemical assays were performed to evaluate the neuroprotective mechanisms of CTELE. Our results demonstrate that CTELE treatment ameliorated motor deficits in PD animal models, as evidenced by improved locomotor activity and coordination. Furthermore, histological analysis revealed a preservation of dopaminergic neurons in the substantia nigra pars compacta of CTELE-treated animals compared to untreated controls. Biochemical analysis showed a reduction in oxidative stress markers and an increase in antioxidant enzyme activity in CTELE-treated animals, suggesting its potential neuroprotective effects. These findings suggest that CTELE may hold promise as a natural therapeutic agent for PD and warrant further investigation into its underlying mechanisms of action and clinical efficacy. Keywords: Cassia tora leave, Parkinson’s disease.
PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.
EVALUATION OF THE ANTIEPILEPTIC EFFECT OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODEL USING MAXIMAL ELECTROSHOCK SEIZURE (MES) Sahoo, Snehalata; Ray, Jassaswi; Prusty, Shaktiketan; Mohanty, R.
Journal of Global Pharma Technology Volume 16 Issue 09 (2024) September 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Epilepsy, a neurological disorder characterized by recurrent seizures, poses significant challenges to affected individuals due to its diverse etiology and limited therapeutic options. This thesis explores the potential therapeutic efficacy of ethanolic extracts derived from Cassia tora leaves in managing epilepsy. Through preclinical investigations, the study aims to elucidate the pharmacological mechanisms underlying the antiepileptic properties of Cassia tora, shedding light on its viability as a complementary or alternative therapy for epilepsy management. Experimental methodologies include in vitro assays to assess neuroprotective effects, in vivo animal models to evaluate seizure severity and frequency, as well as biochemical analyses to elucidate the extract's impact on neurotransmitter systems and oxidative stress pathways. Results from this research endeavor contribute valuable insights into the development of novel therapeutic interventions for epilepsy, potentially enriching the existing armamentarium of antiepileptic drugs and enhancing patient outcomes. Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions worldwide. Current pharmacological treatments often have limitations, prompting exploration into alternative therapies such as herbal extracts. Cassia tora, known for its medicinal properties, is hypothesized to possess antiepileptic effects. This thesis investigates the potential of Cassia tora ethanolic leaf extract in mitigating seizures induced by maximal electroshock (MES) in animal models. Keywords: Cassia tora (C.T), Chrysophanol, Emodin, Anthraquinones, Rat.
RECENT DRUG DISCOVERY STATUS AGAINST PEPTIC ULCER Panda, Girija Shankar; Sahoo, Deeptitapa; Ray, Jassaswi; Mohanty, R.; Nayak, Ritesh Kumar
Journal of Global Pharma Technology Volume 16 Issue 10 (2024) October 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Peptic ulcer is a customary disease, it affecting around 5-10% of the general population worldwide, but with notable regional and rectal variants. The two most common etiological causes are the chronic infection with Helicobacter Pylori (HP) and the uses of nonsteroidal anti-inflammatory drugs (NSAIDS). Its diagnosis is based mainly in the endoscopy and the active search of contaminant Helicobacter pylori presence. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid, pepsin, refluxed bile, leukotrienes, relative oxygen species and defensive factors, which include the function of the mucus, bicarbonate barrier, prostaglandins, mucosal blood flow, cell renewal and migration, non-enzymatic and enzymatic antioxidants and some growth factors. Keywords: Helicobacter Pylori, NSAID, Proton Pump Inhibiter, Leukotriene, Bicarbonate Barrier, Refluxed Bile.
EXPLORING THE ANTI-PARKINSONIAN POTENTIAL OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODELS Mishra, Bandana; Ray, Jassaswi; Prusty, S.K.; Mohanty, Rajashree; Patra, Anup Ku
Journal of Global Pharma Technology Volume 16 Issue 11 (2024) November 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments resulting from the loss of dopaminergic neurons. Current treatments provide symptomatic relief but do not halt disease progression. In this study, we investigated the potential therapeutic effects of Cassia tora ethanolic leaves extract (CTELE) on PD using animal models. CTELE, known for its rich bioactive compounds, was administered orally to PD-induced animals, and their behavioral responses were assessed using standard motor function tests. Additionally, histopathological examination and biochemical assays were performed to evaluate the neuroprotective mechanisms of CTELE. Our results demonstrate that CTELE treatment ameliorated motor deficits in PD animal models, as evidenced by improved locomotor activity and coordination. Furthermore, histological analysis revealed a preservation of dopaminergic neurons in the substantia nigra pars compacta of CTELE-treated animals compared to untreated controls. Biochemical analysis showed a reduction in oxidative stress markers and an increase in antioxidant enzyme activity in CTELE-treated animals, suggesting its potential neuroprotective effects. These findings suggest that CTELE may hold promise as a natural therapeutic agent for PD and warrant further investigation into its underlying mechanisms of action and clinical efficacy. Keywords: Cassia tora leave, Parkinson’s disease.
PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.
Co-Authors Dash, Deepti Prangya Mishra, Bandana Mohanty, R. Mohanty, Rajashree Nayak, Ritesh Kumar Panda, Girija Shankar Patra, Anup Ku Prusty, S.K. Prusty, Shaktiketan Sahoo, Deeptitapa Sahoo, Snehalata