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Mohanty, R.
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Medicine & Pharmacology

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EVALUATION OF THE ANTIEPILEPTIC EFFECT OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODEL USING MAXIMAL ELECTROSHOCK SEIZURE (MES) Sahoo, Snehalata; Ray, Jassaswi; Prusty, Shaktiketan; Mohanty, R.
Journal of Global Pharma Technology Volume 16 Issue 09 (2024) September 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Epilepsy, a neurological disorder characterized by recurrent seizures, poses significant challenges to affected individuals due to its diverse etiology and limited therapeutic options. This thesis explores the potential therapeutic efficacy of ethanolic extracts derived from Cassia tora leaves in managing epilepsy. Through preclinical investigations, the study aims to elucidate the pharmacological mechanisms underlying the antiepileptic properties of Cassia tora, shedding light on its viability as a complementary or alternative therapy for epilepsy management. Experimental methodologies include in vitro assays to assess neuroprotective effects, in vivo animal models to evaluate seizure severity and frequency, as well as biochemical analyses to elucidate the extract's impact on neurotransmitter systems and oxidative stress pathways. Results from this research endeavor contribute valuable insights into the development of novel therapeutic interventions for epilepsy, potentially enriching the existing armamentarium of antiepileptic drugs and enhancing patient outcomes. Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions worldwide. Current pharmacological treatments often have limitations, prompting exploration into alternative therapies such as herbal extracts. Cassia tora, known for its medicinal properties, is hypothesized to possess antiepileptic effects. This thesis investigates the potential of Cassia tora ethanolic leaf extract in mitigating seizures induced by maximal electroshock (MES) in animal models. Keywords: Cassia tora (C.T), Chrysophanol, Emodin, Anthraquinones, Rat.
RECENT DRUG DISCOVERY STATUS AGAINST PEPTIC ULCER Panda, Girija Shankar; Sahoo, Deeptitapa; Ray, Jassaswi; Mohanty, R.; Nayak, Ritesh Kumar
Journal of Global Pharma Technology Volume 16 Issue 10 (2024) October 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Peptic ulcer is a customary disease, it affecting around 5-10% of the general population worldwide, but with notable regional and rectal variants. The two most common etiological causes are the chronic infection with Helicobacter Pylori (HP) and the uses of nonsteroidal anti-inflammatory drugs (NSAIDS). Its diagnosis is based mainly in the endoscopy and the active search of contaminant Helicobacter pylori presence. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid, pepsin, refluxed bile, leukotrienes, relative oxygen species and defensive factors, which include the function of the mucus, bicarbonate barrier, prostaglandins, mucosal blood flow, cell renewal and migration, non-enzymatic and enzymatic antioxidants and some growth factors. Keywords: Helicobacter Pylori, NSAID, Proton Pump Inhibiter, Leukotriene, Bicarbonate Barrier, Refluxed Bile.
EVALUATION OF THE ANTIEPILEPTIC EFFECT OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODEL USING MAXIMAL ELECTROSHOCK SEIZURE (MES) Sahoo, Snehalata; Ray, Jassaswi; Prusty, Shaktiketan; Mohanty, R.
Journal of Global Pharma Technology Volume 16 Issue 09 (2024) September 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Epilepsy, a neurological disorder characterized by recurrent seizures, poses significant challenges to affected individuals due to its diverse etiology and limited therapeutic options. This thesis explores the potential therapeutic efficacy of ethanolic extracts derived from Cassia tora leaves in managing epilepsy. Through preclinical investigations, the study aims to elucidate the pharmacological mechanisms underlying the antiepileptic properties of Cassia tora, shedding light on its viability as a complementary or alternative therapy for epilepsy management. Experimental methodologies include in vitro assays to assess neuroprotective effects, in vivo animal models to evaluate seizure severity and frequency, as well as biochemical analyses to elucidate the extract's impact on neurotransmitter systems and oxidative stress pathways. Results from this research endeavor contribute valuable insights into the development of novel therapeutic interventions for epilepsy, potentially enriching the existing armamentarium of antiepileptic drugs and enhancing patient outcomes. Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions worldwide. Current pharmacological treatments often have limitations, prompting exploration into alternative therapies such as herbal extracts. Cassia tora, known for its medicinal properties, is hypothesized to possess antiepileptic effects. This thesis investigates the potential of Cassia tora ethanolic leaf extract in mitigating seizures induced by maximal electroshock (MES) in animal models. Keywords: Cassia tora (C.T), Chrysophanol, Emodin, Anthraquinones, Rat.
RECENT DRUG DISCOVERY STATUS AGAINST PEPTIC ULCER Panda, Girija Shankar; Sahoo, Deeptitapa; Ray, Jassaswi; Mohanty, R.; Nayak, Ritesh Kumar
Journal of Global Pharma Technology Volume 16 Issue 10 (2024) October 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Peptic ulcer is a customary disease, it affecting around 5-10% of the general population worldwide, but with notable regional and rectal variants. The two most common etiological causes are the chronic infection with Helicobacter Pylori (HP) and the uses of nonsteroidal anti-inflammatory drugs (NSAIDS). Its diagnosis is based mainly in the endoscopy and the active search of contaminant Helicobacter pylori presence. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid, pepsin, refluxed bile, leukotrienes, relative oxygen species and defensive factors, which include the function of the mucus, bicarbonate barrier, prostaglandins, mucosal blood flow, cell renewal and migration, non-enzymatic and enzymatic antioxidants and some growth factors. Keywords: Helicobacter Pylori, NSAID, Proton Pump Inhibiter, Leukotriene, Bicarbonate Barrier, Refluxed Bile.
Co-Authors Nayak, Ritesh Kumar Panda, Girija Shankar Prusty, Shaktiketan Ray, Jassaswi Sahoo, Deeptitapa Sahoo, Snehalata