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All Journal Jurnal Kedokteran Universitas Palangka Raya Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Habibah, Ulil Albab
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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PROFIL MANIFESTASI KLINIS DAN LABORATORIUM PASIEN DEMAM TIFOID DI RS PKU BANTUL Devita, Ninda; Riski, Muhammad Syafiq; Marufi, Rian; Habibah, Ulil Albab
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.10753

Abstract

Typhoid fever can give various clinical manifestations and laboratoryThis study is a retrospective descriptive study using medical record data. The data collected was clinical manifestations and laboratory then presented in a frequency distribution diagram. A total of 72 typhoid fever patients at PKU Hospital Bantul in 2014-2015 were included as subjects. A 53% of the subjects were women. The mean age was 32 ± 14 years. The main symptoms were fever (99%), gastrointestinal symptoms (91%), headache (37%), muscle aches (11%), and cough (8%). The dominant physical examination found hepatomegaly and dirty tongue (19% and 5%). The main laboratory abnormalities were increased SGOT (46%), SGPT (39%), anemia (26%), and leukopenia (22%) It was concluded, typhoid fever patients often found fever, gastrointestinal symptoms, headache accompanied by anemia, leukopenia, and elevated liver enzymes in laboratory tests.
Potensi miRNA sebagai Biomarker Diagnosis Dini Penyakit Hati Kronis Pasca Infeksi Hepatitis B : Sebuah Tinjauan Pustaka Devita, Ninda; Habibah, Ulil Albab; Arjana, Adika Zhulhi
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss2.art10

Abstract

Inflamasi kronis pasca infeksi virus hepatitis B menyebabkan kondisi infeksi kronis, fibrosis hingga keganasan. Modalitas diagnosis non invasif yang ada saat ini masih terbatas. Pemeriksaan non invasif dengan kemampuan diagnosis yang tinggi dibutuhkan untuk deteksi dini kondisi ini. miRNA berperan dalam patomekanisme inflamasi kronis pasca infeksi virus hepatitis B. Bebagai data menunjukkan kadar miRNA serum ditemukan berbeda signifikan pada pasien hepatitis B kronis, sirosis hati dan kanker hati. Walaupun data yang ada saat ini hasilnya masih bervariasi, bukti ilmiah menunjukkan korelasinya dengan proses imunologis, virologis, tumorgenesis, dan perubahan fibrosis pasca infeksi Hepatitis B. Pemeriksaan miRNA baik secara tunggal, kombinasi beberapa miRNA atau dengan modalitas diagnosis lain memiliki kemampuan diagnosis yang tinggi. miRNA potensial sebagai marker diagnosis dini berbagai kondisi pasca infeksi virus Hepatitis B. Kata Kunci: miRNA; hepatitis B; deteksi dini; biomarker
Co-Authors Adika Zhulhi Arjana Marufi, Rian Ninda Devita, Ninda Riski, Muhammad Syafiq