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All Journal Medica Hospitalia Diponegoro International Medical Journal (DIMJ)
Handayani, Peny
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy Handayani, Peny; Budiarti, Rery; Yusmawan, Willy; Antono, Dwi; Dewi, Anna Mailasari Kusuma; Widodo , Pujo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.854

Abstract

BACKGROUND: Oral mucositis is an injury of normal mucosal tissue with an acute inflammation of the oral, tongue, and pharyngeal mucosa after exposure to chemo-radiotherapy. Post chemoradiotherapy oral mucositis is commonly accompanied by painful swallowing or odynophagia. Povidone iodine 1% is an antiseptic mouthwash that widely used to prevent infections in the oral cavity. OBJECTIVE: The aim of this study was to determine the effect of 1% povidone iodine mouthwash on the incidence of oral mucositis in patients with head and neck malignancy at Dr. Kariadi General Hospital Semarang.    METHOD: This study was single random blinded experimental study, with total samples of 44 patients with head and neck malignancy after chemoradiotherapy. The samples divided into treatment group of 22 samples with 1% povidone iodine mouthwash and control group of 22 samples with NaCl 0.9% recruited using single random sampling at Dr. Kariadi Semarang General Central Hospital in 2022. The effect of 1% povidone iodine mouthwash on the incidence of oral mucositis and odynophagia was analyzed using the Fischer Exact and Mann Whitney test. RESULT: In the 1% povidone iodine mouthwash group day 15th, 21 patients (95.5%) were found without mucositis and 1 patient (4.5%) with mucositis oral grade I. In the 1% povidone iodine mouthwash group, 21 people (4.5%) were found without odynophagia and 1 people (4.5%) had odynophagia. There was an association between oral mucositis and odynophagia on povidone iodine 1% group (p < 0.05).        CONCLUSION: Povidone iodine 1% mouthwash can affect the incidence of oral mucositis in patients with head and neck carcinoma. Povidone iodine 1% mouthwash can reduce the incidence of oral mucositis and odynophagia compared to placebo in patients with head and neck carcinoma.
The Association between Obstructive Sleep Apnea and Glycated Haemoglobin A1c (Hba1c) Level in Diabetes Mellitus Type II Patient Dewi, Anna Mailasari Kusuma; Handayani, Peny; Rachma, Devi Elvina; Limijadi, Edward Kurnia Setiawan
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15191

Abstract

Abstract Background: Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive episodes of upper airway collapse, apnea, and arousal during sleep. OSA and type 2 diabetes mellitus (T2DM) are common comorbid conditions. Haemoglobin A1c (HbA1c) is an approximation of an individual’s average blood glucose level for the prior two to three months, and therefore is considered to be a major index for monitoring glycaemic control in diabetic patientsObjective: This study aimed to examine the association between OSA and HbA1c levels in T2DM patients.Methods: This was a cross-sectional study. The study assesses the association between OSA and HbA1c levels in 75 T2DM patients. OSA in the patient was asses with Epworth Sleepiness Scale (ESS) questionnaire. HbA1c values were obtained from the patient’s records. Data presented in mean ± SD, max, and min. Correlations analyses using Pearson correlation coefficient with p < 0.05 were considered statistically significant.Results: A total of 75 T2DM has a mean BMI were 25.26 ± 48.31 kg/m2 with mean HbA1c levels of about 7.1 ± 0.19%. The mean ESS score was 5 ± 0.429. The very weak correlation between OSA and BMI was statistically significant, r = 0.213; p = 0.047. Meanwhile, a very weak correlation between OSA and HbA1c levels was not statistically significant, r = 0.137; p = 0.242Conclusion: Among adults with T2DM, the correlation between OSA with HbA1c was not statistically significant
Co-Authors Antono, Dwi Budiarti, Rery Dewi, Anna Mailasari Kusuma Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Rachma, Devi Elvina Widodo , Pujo Willy Yusmawan, Willy