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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Health Education Medica Hospitalia
Budiarti, Rery
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Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health

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Determinant of Voice Handicap Index Degree as Dysphonia Patients’ Quality of Life Indicator Yusuf, Muhammad; Dewi, Anna Mailasari Kusuma; Yunika, Kanthi; Yusmawan, Willy; Farokah, Farokah; Budiarti, Rery; Muyassaroh, Muyassaroh
JHE (Journal of Health Education) Vol 6 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang cooperate with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jhe.v6i1.42118

Abstract

Background: Dysphonia will interfere with communication which will have an impact on social life such as depression, disrupt activities, work and can affect the quality of life. Dysphonia risk factors such as age, sex, duration of illness and etiology will affect the course of it. The purpose of this study was to identify risk factors for with the degree of Voice Handicap Index (VHI) as an indicator of dysphonia patients.Methods: Analytical descriptive study with cross-sectional design in dysphonia patients, the sample was determined as many as 62 who met the inclusion criteria. Quality of life was assessed by the VHI questionnaire. VHI degrees are classified into mild and moderate-severe. Data analysis using chi-square test and multivariate logistic regression. Results:Thirty-two (51.6%) subjects were women. Mean age was 47.26 +12.2. The most common causes of dysphonia (85.5%) were due to organic disorders and laryngopharyngeal reflux (LPR) is the most common cause (37.1%) of all organic dysphonia disorders. Analysis of risk factors for age, gender, etiology of dysphonia and duration of illness with VHI degree were p = 0.282, p =0.76, p= 0.067, p= 0.001, respectively. Duration of illness ≥2 weeks has a 38.3x risk to severity VHI compared to <2 weeks. Conclusion: The duration of illness is a determinan related to of the degree of VHI that quality of life indicator in dysphonia patients. Key Words: Risk factors, Dysphonia, Voice Handicap Index
Determinant of Voice Handicap Index Degree as Dysphonia Patients’ Quality of Life Indicator Yusuf, Muhammad; Dewi, Anna Mailasari Kusuma; Yunika, Kanthi; Yusmawan, Willy; Farokah, Farokah; Budiarti, Rery; Muyassaroh, Muyassaroh
Journal of Health Education Vol 6 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang cooperate with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jhe.v6i1.42118

Abstract

Background: Dysphonia will interfere with communication which will have an impact on social life such as depression, disrupt activities, work and can affect the quality of life. Dysphonia risk factors such as age, sex, duration of illness and etiology will affect the course of it. The purpose of this study was to identify risk factors for with the degree of Voice Handicap Index (VHI) as an indicator of dysphonia patients.Methods: Analytical descriptive study with cross-sectional design in dysphonia patients, the sample was determined as many as 62 who met the inclusion criteria. Quality of life was assessed by the VHI questionnaire. VHI degrees are classified into mild and moderate-severe. Data analysis using chi-square test and multivariate logistic regression. Results:Thirty-two (51.6%) subjects were women. Mean age was 47.26 +12.2. The most common causes of dysphonia (85.5%) were due to organic disorders and laryngopharyngeal reflux (LPR) is the most common cause (37.1%) of all organic dysphonia disorders. Analysis of risk factors for age, gender, etiology of dysphonia and duration of illness with VHI degree were p = 0.282, p =0.76, p= 0.067, p= 0.001, respectively. Duration of illness ≥2 weeks has a 38.3x risk to severity VHI compared to <2 weeks. Conclusion: The duration of illness is a determinan related to of the degree of VHI that quality of life indicator in dysphonia patients. Key Words: Risk factors, Dysphonia, Voice Handicap Index
Factors Associated with Hearing Loss in Helicopter Aircrew of Indonesian Army Aviation Center, Semarang Muyassaroh, Muyassaroh; Sayuti, Fajri Imam; Ruspita, Dian Ayu; Dewi, Anna Mailasari kusuma; Budiarti, Rery; Naftali, Zulfikar; Widodo, Pujo
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): December 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.258 KB) | DOI: 10.30659/sainsmed.v12i2.12819

Abstract

Introduction: Hearing loss and tinnitus may occur in pilots due to exposure of the high noise level (ranges from 104-110 dB) generated by aircraft/helicopters. In addition, flying time, acoustic trauma, diabetes mellitus, hypertension and smoking are risk factors of hearing loss. Objective: to identify the factors associated with hearing loss in the crew of the Indonesian Army Aviation Center, SemarangMethods: in the cross-sectional research, 114 military helicopter aircrews aged 20-58 years, working for the Army Aviation Center in Semarang were included. The exclusion criteria were history of previous ear surgery, infection of the outer and middle ear, the use of ototoxic drugs (kanamycin, cisplatin and carboplatin). The level of hearing loss and tinitus was assessed by otoscopy and audiometry. Whereas, tinnitus was obtained from the history taking. Data were analyzed using chi-square test and fisher's exact and Yates’s correction.Results: One hundred and fourteen subjects (mean age of 26.54 + 4.72) were included. Several factors such as flight time (p = 0.698), acoustic trauma (p = 0.151), diabetes mellitus (p = 0.596), smoking (p = 0.222), hypertension (p = 0.356) were not associated with sensorineural hearing loss. Several factors such as flight time (p = 0.706), acoustic trauma (p = 0.5160), diabetes mellitus (p = 0.789), smoking (p = 0.495), hypertension (p = 0.112) were not associated with tinnitus.Conclusion: There is no association between flight time, acoustic trauma, diabetes mellitus, hypertension, and smoking and hearing loss.
Kejadian Mielosupresi Pada Penderita Kanker Kepala Dan Leher Yang Mendapat Kemoterapi Cisplatin Dan Carboplatin Di RSUP Dr. Kariadi Semarang Dewi, Nila Santia; Yusmawan, Willy; Budiarti, Rery
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.673 KB) | DOI: 10.36408/mhjcm.v7i1.425

Abstract

Latar belakang : Kemoterapi bersifat sistemik dan non selektif sehingga tidak hanya sel kanker yang mati tetapi juga sel normal. National Comprehensive Cancer Network (NCCN) merekomendasikan Platinum-based sebagai rejimen kemoterapi untuk kanker kepala dan leher terutama Cisplatin dan Carboplatin. Cisplatin dan Carboplatin dapat menyebabkan efek samping mielosupresi. Tujuan : Membuktikan bahwa terdapat perbedaan kejadian mielosupresi pada penderita Kanker Kepala dan Leher (KKL) yang mendapat kemoterapi Cisplatin dan Carboplatin. Metode : Penelitian observasional dengan desain penelitian kohort prospektif di klinik THT-KL, bangsal dan bagian rekam medis instalasi rawat jalan/rawat inap RSUP Dr. Kariadi Semarang. Sampel ditentukan sebanyak 90 orang dan mendapat kemoterapi platinum based dengan salah satu komponen berupa Cisplatin atau Carboplatin sebanyak 3 seri. Analisis data dengan uji Pearson Chi-square dan Fisher’s exact test. Hasil : Subyek penelitian 90 orang, 45 orang mendapatkan Paclitaxel Cisplatin dan 45 orang mendapatkan regimen Paclitaxel Carboplatin. Hasil penelitian ini didapatkan 48,9% pasien stadium IV, histopatologi terbanyak WHO 3 (83,3%). Rerata usia terbanyak 50-59 tahun, dan diagnosis terbanyak pada KNF (66,7%). Secara keseluruhan kemoterapi seri I menunjukkan Carboplatin menyebabkan perubahan kadar hemoglobin (p=1,000) dan leukosit (p=0,292) dengan jumlah subyek lebih banyak dibanding Cisplatin. Sedangkan pada kemoterapi seri III, Carboplatin menyebabkan perubahan kadar hemoglobin (p=<0,023), leukosit (p=0,670), dan trombosit (p=1,000) lebih banyak dibandingkan Cisplatin. Simpulan : Kadar hemoglobin berbeda bermakna pada pasien yang mendapatkan kemoterapi Carboplatin seri III (p<0,023). Kata kunci : Kemoterapi Cisplatin/Carboplatin., kanker kepala dan leher, mielosupresi. Background : Chemotherapy is systemic and non-selective so it often results in not only cancer cells dying but normal cells will also die. The National Comprehensive Cancer Network (NCCN) recommends Platinum-based chemotherapy regimens for head and neck cancer, especially Cisplatin and Carboplatin. Cisplatin and Carboplatin chemotherapy can cause one of the side effects of myelosuppression. Myelosuppression is a decrease in cell production of leukocytes, erythrocytes, and / or platelets. Objective : Proving the difference incidence of myelosuppression in head and neck cancer patients receiving Cisplatin and Carboplatin chemotherapy. Methode : An observational study with a prospective cohort study design in ENT clinic, ward and medical record department of outpatient installation Dr. Kariadi Semarang. Samples was determined by 90 people and received platinum based chemotherapy with one component in the form of Cisplatin or Carboplatin in 3 series. Data analysis by Pearson Chi-square and Fisher’s exact test. Result : The study subjects were 90 people, 45 people received Paclitaxel Cisplatin regimen and 45 people received Paclitaxel Carboplatin regimen. The results of this study found 48.9% of patients in stage IV conditions with the most histopathological types were WHO 3 (83.3%). Overall series I chemotherapy shows Carboplatin causes changes in hemoglobin (p=1,000) and leukocyte (p=0,292) levels with a greater number of subjects than Cisplatin. Where as in series III chemotherapy, Carboplatin causes more changes in hemoglobin (p=<0,023), leukocyte (p=0,670) and platelet (p=1,000) levels than Cisplatin. Conclusions : Hemoglobin level was significantly different in patients who received Carboplatin series III chemotherapy (p<0,023). Keywords : Chemotherapy, head and neck cancer, myelosuppression, Cisplatin, Carboplatin.
PENGARUH SUPLEMENTASI KOENZIM Q10 TERHADAP KADAR LAKTAT DEHIDROGENASE PENDERITA LIMFOMA NON-HODGKIN YANG MENJALANI KEMOTERAPI DI RSUP Dr.KARIADI SEMARANG Kusulistyo, Farryanto; Suprihati, Suprihati; Yusmawan, Willy; Antono, Dwi; Budiarti, Rery; Farokah, Farokah; Widodo, Pujo
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.886 KB) | DOI: 10.36408/mhjcm.v8i2.580

Abstract

LATAR BELAKANG : Peningkatan kadar LDH dikenal sebagai penanda tumor yang menggambarkan aktivitas tumor termasuk tumor sel germinal, sarkoma dan LNH. Koenzim Q10 bekerja sebagai kofaktor dalam Siklus Krebs yang berperan dalam mengatasi kondisi kekurangan ATP dalam sel melalui reaksi reduksi dan oksidasi. TUJUAN : Membuktikan pengaruh pemberian koenzim Q10 terhadap kadar LDH penderita LNH yang mendapat kemoterapi di RSUP Dr.Kariadi, Semarang. METODE : Penelitian intervensi dengan desain randomized pre and post test double blind control group design. Subyek yang ditentukan sebanyak 34 orang. Subjek penelitian adalah penderita LNH yang mendapat kemoterapi dengan pemberian terapi selama 21 hari. Kelompok penelitian dibagi menjadi 2, yaitu kelompok perlakuan (penderita LNH yang mendapat kemoterapi, dan koenzim Q10 100mg/hari) sebanyak 17 orang, serta kelompok kontrol (penderita LNH yang mendapat kemoterapi dan plasebo) sebagai sisanya. Analisis data dengan deskriptif dan uji hipotesis HASIL : Terdapat perbedaan signifikan sebelum dan setelah intervensi, dimana terjadi penurunan kadar LDH pada kelompok perlakuan sedangkan pada kelompok kontrul justru terjadi peningkatan kadar LDH. KESIMPULAN : Kadar LDH pada pasien LNH yang diberikan koenzim Q10, lebih baik dibandingkan tanpa pemberian koenzim Q10. Terdapat perbedaan bermakna secara statistik pada penelitian ini Kata Kunci : Limfoma Non-Hodgkin (LNH); Lactate Dehidrogenase (LDH); Koenzim Q10, prognosis
Faktor Risiko Disfagia pada Pasien Diabetes Mellitus: Risk Factors of Dysphagia in Patients with Diabetes Mellitus Mudha Pratomo, Santo; Mailasari Kusuma Dewi, Anna; Iman Santosa, Yanuar; Antono, Dwi; Tedjo Minuljo, Tania; Budiarti, Rery
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 2 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.02 KB) | DOI: 10.36408/mhjcm.v9i2.759

Abstract

Latar belakang : Disfagia dapat terjadi akibat komplikasi dari diabetes mellitus terutama pada fase orofaringeal. Disfagia pada diabetes mellitus terjadi karena adanya neuropati autonom akibat hiperglikemia yang lama. Komplikasi ini mempengaruhi berbagai bagian sistem saraf dan mempunyai manifestasi klinis yang beragam, salah satunya adalah kerusakan metabolik pada struktur saraf dan mikrovaskuler dari vasa vasorum. Penelitian ini bertujuan untuk membuktikan bahwa usia, jenis kelamin, merokok, BMI dan kadar HbA1c merupakan faktor risiko disfagia pada penderita Diabetes mellitus (DM). Metode : Penelitian observasional analitik dengan desain belah lintang melibatkan subjek sebanyak 95 penderita DM dewasa di klinik Penyakit Dalam RSUP Dr. Kariadi Semarang pada bulan Desember 2021 – Februari 2022. Disfagia dinilai dari kuisioner dan pemeriksaan penelanan. Data DM dan HbA1c diambil dari rekam medik. Analisis data menggunakan Chi-Square dan regresi logistic. Hasil : Rerata usia 51,61 + 8,706 dengan usia termuda 18 tahun dan usia tertua 60 tahun. jenis kelamin laki laki : perempuan = 6 : 13. Usia (p= 0,523), jenis kelamin (p= 0,043, RP -2,76 CI 95% 0,883 – 8,686) riwayat merokok (p= 0,602), status BMI (p= 0,660), dan kadar HbA1c (p= 0,679), Simpulan : Usia, jenis kelamin riwayat merokok, status BMI dan kadar HbA1c tidak merupakan faktor risiko terjadinya disfagia pada penderita diabetes mellitus.
Satu Kasus Diagnostik Disfagia pada Bayi dengan Pemeriksaan FEES (Flexible Endoscopy Evaluation of Swallowing: A case of dysphagia diagnostic in baby with FEES (Flexible endoscopy evaluation of swallowing) Dewi, Nila Santia; Budiarti, Rery; Muyassaroh, Muyassaroh
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 2 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.855 KB) | DOI: 10.36408/mhjcm.v9i2.781

Abstract

Latar belakang : Disfagia adalah gangguan proses menelan yang dapat mengganggu keselamatan dan kecukupan nutrisi. Disfagia pada bayi terjadi 85% pada anak-anak penyandang cacat dan 5% anak-anak perkembangan biasa. Tujuan penulisan laporan kasus ini untuk mengetahui sejak dini penyebab disfagia pada bayi sehingga dapat dilakukan tatalaksana segera agar tidak mengganggu pertumbuhan dan perkembangan bayi. Laporan kasus : Dilaporkan satu kasus anak laki-laki usia 2 bulan dengan disfagia fase orofaringeal e.c curiga komplikasi iatrogenik dan perilaku. Hasil pemeriksaan Fiberoptic Endoscopic Evaluation of Swallow (FEES) didapatkan kesan kelemahan otot daerah sinus piriformis sisi kiri. Pembahasan : Disfagia pada bayi dapat merugikan dan berpengaruh terhadap asupan nutrisi makanan sehingga mengganggu pertumbuhan dan perkembangan anak. Penyebab disfagia pada bayi yaitu prematur, kelainan neurologi, masalah maternal & perinatal, abnormalitas kongenital, gangguan pernafasan & jantung, gangguang saluran cerna, dan komplikasi iatrogenik. Diagnosis disfagia pada bayi ditegakkan dengan evaluasi klinis, instrumental alat dengan pemeriksaan Videofluoroscopic Swallowing Study (VFSS) sebagai standar emas dan Fiberoptic Endoscopic Evaluation of Swallow (FEES) sebagai alternatif. Simpulan : Disfagia pada kasus ini termasuk disfagia fase orofaringeal dicurigai terjadi karena komplikasi iatrogenik (pemakain NGT) dengan FEES sebagai pemeriksaan penunjang.
FAKTOR RISIKO OBSTRUCTIVE SLEEP APNEA PADA PASIEN DIABETES MELLITUS : FAKTOR RISIKO OBSTRUCTIVE SLEEP APNEA PADA PASIEN DIABETES MELLITUS Patria, Dimas Adi; Budiarti, Rery; Ayu Ruspita, Dian; Yunika, Kanti; Tedjo Minuljo, Tania; Farokah, Farokah
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.824

Abstract

LATAR BELAKANG : Sleep Disordered Breathing(SDB) memiliki hubungan dua arah dengan sindrom metabolik seperti Diabetes Mellitus (DM) dan hipertensi, komponen sindrom metabolik meningkatkan risiko terjadinya SDB. IMT >30 kg/m2, aktivitas fisik, lingkar leher >40 cm dan hipertensi berisiko tinggi terhadap kejadian SDB. SDB telah terbukti meningkatkan risiko dan keparahan DM, sehingga penanganan SDB dibutuhkan untuk tindakan preventif  DM. TUJUAN : Mengetahui bahwa obesitas, lingkar leher besar, hipertrofi konka inferior, deviasi septum hidung, hipertrofi tonsila palatina, makroglosia, obstruksi saluran nafas atas dan hipertensi merupakan faktor resiko yang mempengaruhi kejadian SDB pada penderita DM. METODE : Penelitian observasional analitik dengan desain cross sectional melibatkan subyek sebanyak 57 penderita DM rawat jalan di Poli Penyakit Dalam RSUP Kariadi Semarang yang memenuhi kriteria inklusi pada bulan Januari 2022 - Maret 2022. Data diperoleh dari rekam medik, kuesioner ESS, pemeriksaan fisik THT dan pemeriksaan Laryngoscopy Flexible. Analisis menggunakan uji chi-square dan uji regresi multivariat. HASIL : Rerata usia 51.87 tahun, dengan SD 9.094, termuda usia 27 tahun, tertua usia  63 tahun. Laki-laki sebanyak 28(49.1%) dan perempuan 29 (50.9%). Obesitas (p= 0,036), lingkar leher besar(p=0.017), hipertrofi konka inferior(p=0,020), makroglossia(p=0,012), hipertrofi tonsila palatina(p=0,017), hipertensi (p=0,001), dan obstruksi saluran nafas atas(p=0,020) merupakan faktor risiko SDB pada penderita DM. Analisis regresi multivariat didapatkan obesitas (p=0,043 RP=13,387.CI 95%:1,083-165,475)dan hipertropi tonsil palatina(p=0,019 RP=9,703.CI 95%=1,446-65,121) merupakan faktor risiko yang paling dominan. SIMPULAN : Obesitas, lingkar leher besar, hipertrofi konka inferior, makroglossia, hipertrofi tonsila palatina, hipertensi, dan obstruksi saluran nafas atas merupakan faktor resiko SDB pada penderita DM. Obesitas dan hipertropi tonsil palatina merupakan faktor risiko yang paling dominan KATA KUNCI: SDB, DM, faktor risiko, hipertrofi tonsil, makroglosia
OSA FAKTOR RISIKO KEJADIAN OBSTRUCTIVE SLEEP APNEA PADA PASIEN STROKE ISKEMIK: - Rosyidah, Nurul Uly; Mailasari Kusuma Dewi, Anna; Marliyawati, Dwi; Yunika, Kanti; Suryawati, Herlina; Budiarti, Rery
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.826

Abstract

LATAR BELAKANG: Sleep Disordered Breathing (SDB)  memiliki hubungan dua arah dengan stroke iskemik. SDB yang tidak diobati dapat menyebabkan stroke berulang. Penanganan SDB adalah kunci untuk preventif pada pasien stroke. TUJUAN: Menganalisis IMT, lingkar leher besar, deviasi septum, hipertrofi konka, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas sebagai faktor risiko SDB pasien stroke iskemik. METODE: Penelitian observasional dengan desain cross sectional, pada 86 pasien stroke iskemik di Poli Neurologi dan THT-KL RSUP Kariadi Semarang bulan Desember 2021-Juli 2022. Data diperoleh melalui kuesioner, pemeriksaan fisik dan pemeriksaan nasolaringoskopi fleksibel. Analisis menggunakan uji chi-square dan uji regresi multivariat. HASIL: Didapatkan 86 subjek terdiri dari 42 laki-laki(48,8%) dan perempuan 44 (51,2%), usia rerata 54 th, dan 61 subjek (70,9%) stroke iskemik pertama. Septum deviasi (p= 0,020), hipertrofi konka inferior (p= 0,021), makroglosia (p= 0,012), hipertrofi tonsila palatina (p= 0,013), dan obstruksi saluran nafas atas (p= 0,035) merupakan faktor risiko SDB pada pasien stroke iskemik. Septum deviasi berisiko 6,1x, konka inferior hipertrofi berisiko 4,1x, dan hipertrofi tonsila palatina  berisiko 8,8x terhadap SDB pada pasien stroke iskemik. SIMPULAN: Septum deviasi, konka inferior hipertrofi, makroglossia, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas merupakan faktor resiko terhadap SDB pasien stroke iskemik. Hipertrofi tonsila palatina merupakan faktor risiko yang paling dominan terhadap SDB pasien stroke iskemik. KATA KUNCI: SDB, faktor risiko, stroke iskemik, hipertrofi tonsila palatina, septum deviasi
The Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy Handayani, Peny; Budiarti, Rery; Yusmawan, Willy; Antono, Dwi; Dewi, Anna Mailasari Kusuma; Widodo , Pujo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.854

Abstract

BACKGROUND: Oral mucositis is an injury of normal mucosal tissue with an acute inflammation of the oral, tongue, and pharyngeal mucosa after exposure to chemo-radiotherapy. Post chemoradiotherapy oral mucositis is commonly accompanied by painful swallowing or odynophagia. Povidone iodine 1% is an antiseptic mouthwash that widely used to prevent infections in the oral cavity. OBJECTIVE: The aim of this study was to determine the effect of 1% povidone iodine mouthwash on the incidence of oral mucositis in patients with head and neck malignancy at Dr. Kariadi General Hospital Semarang.    METHOD: This study was single random blinded experimental study, with total samples of 44 patients with head and neck malignancy after chemoradiotherapy. The samples divided into treatment group of 22 samples with 1% povidone iodine mouthwash and control group of 22 samples with NaCl 0.9% recruited using single random sampling at Dr. Kariadi Semarang General Central Hospital in 2022. The effect of 1% povidone iodine mouthwash on the incidence of oral mucositis and odynophagia was analyzed using the Fischer Exact and Mann Whitney test. RESULT: In the 1% povidone iodine mouthwash group day 15th, 21 patients (95.5%) were found without mucositis and 1 patient (4.5%) with mucositis oral grade I. In the 1% povidone iodine mouthwash group, 21 people (4.5%) were found without odynophagia and 1 people (4.5%) had odynophagia. There was an association between oral mucositis and odynophagia on povidone iodine 1% group (p < 0.05).        CONCLUSION: Povidone iodine 1% mouthwash can affect the incidence of oral mucositis in patients with head and neck carcinoma. Povidone iodine 1% mouthwash can reduce the incidence of oral mucositis and odynophagia compared to placebo in patients with head and neck carcinoma.
Co-Authors Antono, Dwi Ayu Ruspita, Dian Dewi, Anna Mailasari Kusuma Dewi, Nila Santia Farokah, Farokah Handayani, Peny Iman Santosa, Yanuar Kanti Yunika, Kanti Kusulistyo, Farryanto Mailasari Kusuma Dewi, Anna Marliyawati, Dwi Mudha Pratomo, Santo Muhammad Yusuf Muyassaroh Muyassaroh Patria, Dimas Adi Pujo Widodo, Pujo Rosyidah, Nurul Uly Ruspita, Dian Ayu sayuti, fajri imam Suprihati - Suryawati, Herlina Tedjo Minuljo, Tania Widodo , Pujo Willy Yusmawan, Willy Yunika, Kanthi Zulfikar Naftali, Zulfikar