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All Journal Jurnal Ilmu dan Teknologi Kesehatan Medica Hospitalia Muhammadiyah Journal of Midwifery (MyJM)
Fajrunni’mah, Rizana
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Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Korelasi Kadar Prokalsitonin (PCT) Dengan Rasio Neutrofil Limfosit (RNL) Pada Pasien COVID-19 Apriliani, Isnawati; Fajrunni’mah, Rizana; Djajaningrat, Husjain; Widiantari, Aninda Dinar; Murtiani, Farida
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.855

Abstract

BACKGROUND: Covid-19 treatment should be done early before the disease progress. Inflammatory biomarker is needed to ascertain the severity of disease as soon as possible.  Neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are two of biomarker that are clinically used around the world. NLR is simpler, can routinely be done and available in peripheral region while PCT is more effective to describe inflammation. PURPOSE: This study aims to determine the correlation of procalcitonin (PCT) levels with neutrophil lymphocyte ratio (NLR) in COVID-19 patients. METHOD: This study is an analytic observational with a cross sectional design. We extracted data from medical record. Samples were 415 COVID-19 patients undergoing inpatient care at the Budhi Asih Hospital, East Jakarta for January - December 2021. RESULTS: Prevalence of male patients more than ≥60 years were 78 patients (18,8%) while female patients were 68 patients (16,4%). Average of PCT level was 1,93 ng/mL (0,02-200 ng/mL). Average of NLR was 5,09 cells/mm3 (0,22-31 cells/mm3). Spearman test proved there was a significant correlation between PCT and NLR levels in COVID-19 patients (p value = 0,0001). CONCLUSION: The higher the PCT level, the higher the NLR value in COVID-19 patients.
Hubungan Antara Lama Penggunaan Kontrasepsi Suntik Depo Medroxy Progesteron Acetate (DMPA) dengan Kadar Kolesterol Total pada Akseptor KB Prasetyorini, Tri; Islami, Yasyavia Hatifah; Fajrunni’mah, Rizana; Karningsih, Karningsih
Muhammadiyah Journal of Midwifery Vol 1, No 2 (2020): Muhammadiyah Journal of Midwifery (MyJM)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.728 KB) | DOI: 10.24853/myjm.1.2.37-44

Abstract

Latar belakang: jumlah penduduk terbanyak di dunia posisi ke-4 adalah Indonesia. Upaya untuk menekan jumlah pertumbuhan penduduk yaitu dengan program Keluarga Berencana (KB). Secara nasional pengguna KB yang paling banyak adalah KB suntik Depo Medroxy Progesteron Acetate (DMPA) yaitu lebih dari 50% dari jumlah peserta KB aktif. DMPA yang mengandung hormon Progesteron dapat mempengaruhi metabolisme lemak, khususnya lipoprotein. Lama pemakaian kontrasepsi suntik lebih dari 1 tahun akan mengakibatkan ketidak seimbangan hormon estrogen dan progesteron yang berakibat penurunan HDL dan peningkatan LDL sehingga akan meningkatkan kadar kolesterol total. Tujuan: diketahuinya hubungan antara lama penggunaan kontrasepsi suntik DMPA dengan kadar kolesterol total pada akseptor KB DMPA. Metode: jenis penelitian yang digunakan observasional analitik cross sectional dengan jumlah sampel sebanyak 35 responden. Uji statistik yang digunakan adalah uji chi-square dengan tingkat kepercayaan 95%.  Hasil: menunjukan bahwa nilai p sebesar 0,011 (p0,05). Hal ini berarti bahwa terdapat hubungan antara lama penggunaan kontrasepsi suntik Depo Medroxy Progesteron Acetate (DMPA) dengan kadar kolesterol total pada akseptor KB. Sehingga semakin lama penggunaan kontrasepsi DMPA maka semakin meningkatkan kadar kolesterol. Kesimpulan: terdapat hubungan antara lama penggunaan kontrasepsi suntik DMPA dengan kadar kolesterol total.
Correlation of C-Reactive Protein (CRP) Levels with D-Dimer Levels in COVID-19 Patients Choirunisa, Churiyyah Eka; Widhyasih, Retno Martini; Fajrunni’mah, Rizana
jitek Vol 11 No 1 (2023): September 2023
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v11i1.1317

Abstract

Coronavirus disease 2019 is caused by SARS-CoV-2 infection. COVID-19 causes increased levels of proinflammatory cytokines, so CRP and d-dimer levels in COVID-19 patients tend to increase. This study aimed to analyze the correlation between C-Reactive Protein (CRP) levels and D-dimer levels in COVID-19 patients. This research method is analytic observational by using cross-sectional secondary data. The population of this study were all COVID-19 inpatients at Budhi Asih Hospital, East Jakarta, with a sample of 338 patients and were taken by random sampling. The results of this study found that female and male COVID-19 patients had the same risk of being infected with female patients as much as 52,7% and male patients amounting to 47,3%. Most COVID-19 patients occurred at the age of ≥60 years, namely 32,2%. All patients, which is 100% patients had high CRP levels, with a mean of 76,06 mg/L. As for D-dimer levels, 47,9% of patients had normal D-dimer levels and 52,1% had high D-dimer levels with an average of 721,48 ng/mL. The results of the Spearman's correlation test obtained a p value = 0,000, so it can be seen that there is a correlation between C-Reactive Protein (CRP) levels and D-dimer levels in COVID-19 patients with a correlation strength of 0,300 (medium). An increase in CRP levels followed by an increase in D-dimer levels but evaluation of other laboratory examination parameters also needs to be considered.
Co-Authors Apriliani, Isnawati Choirunisa, Churiyyah Eka Djajaningrat, Husjain Islami, Yasyavia Hatifah Karningsih Karningsih Murtiani, Farida Prasetyorini, Tri Widhyasih, Retno Martini Widiantari, Aninda Dinar