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Optimasi Dan Formulasi Sediaan Gel Ekstrak Etanol Hydrocotyle Verticillata Thub Dengan Variasi Konsentrasi HPMC Dengan Penambahan Asam Usnat Habibie Deswilyaz Ghiffari; Alqushay Alqushay; Sri Budiasih; Tommy Julianto
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 1 (2024): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i1.155

Abstract

Hydrocotyle verticillata Thub is a plant that can be used to treat burns. Usnic acid can inhibit pathogenic microorganisms and can act as an anti-inflammatory, both of which can contribute to the wound healing process. The aim of this research is to determine the extract of gotu kola leaves which is formulated into a gel preparation. Gel is a semi-solid system produced by small particles or large organic molecules that penetrate through a liquid. The gel is easy to use, easily absorbed into the skin, and contains soothing and moisturizing properties that have a healing effect. Gel formulations were made with varying concentrations of HPMC F1 (8%), F2 (8%), F3 (8%), F4 (9%), F5 (10%). The gel produced organoleptically has a distinctive gel aroma, green to brownish in color. In the homogeneity test, all preparations were homogeneous and there were no granules, the pH test showed a pH value ranging from 5.17-6.36, the spreadability test was 5.1-6.4 cm. In the viscosity test, the results were 9,250-40,000 cps, the adhesion test obtained results in 13-64 seconds and the cycling test was stable during storage. Based on the research that has been carried out, it can be concluded that the ethanol extract of gotu kola leaves (Hydrocotyle verticillata Thub)can be formulated into a gel preparation and the results of the physical evaluation of the ethanol extract gel preparation of gotu kola leaves(Hydrocotyle verticillata Thub) with varying concentrations of HPMC and the addition of usnic acid are satisfactory. condition.
Penetapan Kadar Fenolik Total Ekstrak Daun Jotang (Sphagneticola Trilobata) Dengan Spektrofotometri UV-Vis Ghalib Syukrillah Syahputra; Delladari Mayefis; Tommy Julianto; Lyna Elvira
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 2 No. 1 (2023): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v2i1.2669

Abstract

Phenolic compounds are the largest group of compounds that act as natural antioxidants in plants. One of the plants that has the potential as a natural antioxidant is Jotang (Sphagneticola trilobata). This study aims to determine whether jotang leaf extract (Sphagneticola trilobata) has phenolic content and to determine the total phenolic content in jotang leaf extract (Sphagneticola trilobata). Jotang leaves were extracted by maceration method using methanol solvent. The method of determining total phenolic content was carried out using Folin-ciocaltaeu reagent because phenolic compounds can react with Folin-Ciocalteu to form a solution that can be measured absorbance. As a standard solution, gallic acid is used which is reacted with Folin-Ciocalteau reagent to produce a yellow color indicating that it contains phenolics, after which it is added with Na₂CO₃ solution as a base atmosphere giver. The phytochemical screening of jotang leaf extract showed positive results containing flavonoids, alkaloids, saponins, phenolic compounds, and triterpenoids. Determination of the wavelength of gallic acid obtained maximum 653 nm. The results showed that jotang leaf extract (Sphagneticola trilobata) has phenolic content and obtained total phenolic content of jotang leaf extract of 0.909 mg /g.