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All Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical Science and Herbal Technology
Muzayyidah
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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THE EFFECT OF COMBINATION MENIRAN ROOT (Phylanthus niruri L.) AND JAVA ACID LEAVES (Tamarindus indica L.) on ALOKSAN-INDUCED DARNESS GLUCOSA RATS (Rattus norvegicus) Asri SR, Muhammad; Gisela; Muzayyidah
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Abstract

Meniran root (Phylanthus niruri L.) and tamarind (Tamarindus indica L.) have flavonoid compounds that function to repair pancreatic tissue damage caused by DNA alkyl groups from alloxan induction. This study aims to determine the activity of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaves (Tamarindus indica L.) on blood glucose levels of male rats (Rattus norvegicus) induced by alloxan. This study was carried out experimentally. White rats up to 15 heads were divided into 5 groups. Alloxan induction at a dose of 125 mg/kgBB intraperitoneally to cause pancreatic damage was performed in 5 treatment groups. Three treatment groups were treated with different doses of a combination of meniran and tamarind root extracts, (P1) 7.5 mg/KgBB, (P2) 10 mg/KgBB and (P3) 15 mg/KgBB, one group as negative control (K-) was given 1% Na CMC and positive control (K+) was given 5 mg glibenclamide. The combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) was given for 1 day. Glucose levels were checked after 2 hours, 4 hours, 6 hours and 24 hours of administration. The results showed that the three concentrations of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) can reduce the blood glucose levels of male rats (Rattus norvegicus) induced by alloxan.
Antibacterial Activity Test of Anti-Acne Gel Preparations Containing Ethanol Extracts of Bidara Arab Leaf (Ziziphus spina-christi (L.) Desf) Againts Propionibacterium acnes Muzayyidah; Asri SR, Muhammad; Riska Safitri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 02 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.184 KB) | DOI: 10.58549/pcjn.v2i01.61

Abstract

Bidara arab leaf (Ziziphus spina-christi (L.) Desf) is one of the plants that have the potential as an anti-acne. The content of secondary metabolites contained in bidara arab leaves include alkaloids, polyphenols, flavonoids, saponins, and tannins. These secondary metabolites can inhibit the growth of acne causing bacteria, namely Propionibacterium acnes. The purpose of this study was to create a good gel dosage form of the ethanol extract of bidara arab leaves and to test the antibacterial activity of the gel formulation against Propionibacterium acne. This research method was carried out experimentally on a laboratory scale, namely ethanol extract of bidara arab leaves made in the form of anti-acne gel preparations with several concentration, including F1(1%), F2 (3%), and F3 (5%). Then proceed with the evaluation of the preparation with organoleptic test, homogenity test, pH test, adhesion test, and dispersion test. Anti-acne gel preparations had antibacterial activity based on a concentration of 1% of 12.46 mm (strong), 3% of 13.66 mm (strong), and 5% of 14.71 mm (strong), negative control had no inhibition zone and positive control 20.92 mm (very strong). strong) So, it can be included that the formulation of anti-acne gel preparations able to inhibit the growth of Propionibacterium acnes.
Co-Authors Asri SR, Muhammad Gisela Riska Safitri