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All Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Media Farmasi Journal of Pharmaceutical Science and Herbal Technology
Asri SR, Muhammad
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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THE EFFECT OF COMBINATION MENIRAN ROOT (Phylanthus niruri L.) AND JAVA ACID LEAVES (Tamarindus indica L.) on ALOKSAN-INDUCED DARNESS GLUCOSA RATS (Rattus norvegicus) Asri SR, Muhammad; Gisela; Muzayyidah
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Meniran root (Phylanthus niruri L.) and tamarind (Tamarindus indica L.) have flavonoid compounds that function to repair pancreatic tissue damage caused by DNA alkyl groups from alloxan induction. This study aims to determine the activity of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaves (Tamarindus indica L.) on blood glucose levels of male rats (Rattus norvegicus) induced by alloxan. This study was carried out experimentally. White rats up to 15 heads were divided into 5 groups. Alloxan induction at a dose of 125 mg/kgBB intraperitoneally to cause pancreatic damage was performed in 5 treatment groups. Three treatment groups were treated with different doses of a combination of meniran and tamarind root extracts, (P1) 7.5 mg/KgBB, (P2) 10 mg/KgBB and (P3) 15 mg/KgBB, one group as negative control (K-) was given 1% Na CMC and positive control (K+) was given 5 mg glibenclamide. The combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) was given for 1 day. Glucose levels were checked after 2 hours, 4 hours, 6 hours and 24 hours of administration. The results showed that the three concentrations of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) can reduce the blood glucose levels of male rats (Rattus norvegicus) induced by alloxan.
FORMULATION OF ANTI-ACNE MASK OF PAPAYA LEAF EXTRACT (Carica papaya L.) AND HONEY AGAINST Propionibacterium acn Wali, Putri; Asri SR, Muhammad; Sadsyam, Sriyanty
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Papaya leaves (Carica papaya L.) are ornamental plants that are very useful because they contain alkaloids, flavonoids, saponins, tannins and terpenoids. The alkaloids here have antibacterial properties. Honey is usually used as an antibacterial. Apart from being an antibacterial, honey is also an antioxidant because honey contains vitamin C. Acne (Acne vulgaris) is a skin disease caused by chronic inflammation with a complex pathogenesis, involving the sebaceous glands caused by the bacteria Propiobacerium acne. This research aims to determine whether the anti-acne mask formulation of papaya leaf extract and honey is physically and chemically stable and that the anti-acne mask formulation of papaya leaf extract and honey has anti-acne activity against Propionibacterium acne. This research is an experimental laboratory using the diffusion technique so that the well method is used to determine the diameter of the inhibition zone and for data analysis using the one-way ANOVA test. The results of research on the formulation of an anti-acne mask from papaya leaf extract and honey are physically and chemically stable. The anti-acne mask formulation of papaya leaf and honey extract has antibacterial activity against Propionibacterium acne with an inhibition zone of 17.2 mm (strong) in formulation 1, 19.6 mm (strong) in formulation 2, 19.8 (strong) in formulation 3 and 21.9 mm (very strong) on ​​the positive cotrol, namely benzolac (Benzolic peroxide).
FORMULATION OF LIP TINT FROM EXTRACTS OF KEPOK BANANA FLOWER (Musa paradisiaca Linn.) AND DRAGONFRUIT (Hylocereus polyrhizus) AS NATURAL COLOURS Sudirman, Agriawan; Asri SR, Muhammad; Dahlia
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Lip tint is a cosmetic preparation used to color lips which has liquid texture with a more natural color so that it is easily absorbed and produces a natural color like the lips’ original color. This research aimed to determine whether kepok banana flower peel extract (Musa paradisiaca Linn.) and dragon fruit (Hylocereus polyrhizus) can be formulated in the from of lip tint preparations as natural dyes and to test the antioxidant activity of lip tint preparations. The research method was experimental research by making lip tint formulations with concentrations of FI (2%), FII (6%), and FIII (10%) from banana peel and dragon fruit extracts, evaluating the preparations using physicochemical methods and testing antioxidant activity using the method DPPH using a UV-Vis spectrophotometer. The results showed that the total anthocyanin content in the peel of the kepok banana flower was 0,374 mg/L and in dragon fruit it was 8,232 mg/L. Lip tint preparation formulas with concentrations of 2%, 6% and 10% are physically and chemically stable and the antioxidant activity test in Formula I (2%) obtained an IC50 value of 3,52 µg/mL, Formula II (6%) obtained an IC50 value of 3,91 µg/mL, Formula III (10%) obtained an IC50 value of 1,62 µg/mL and in the positive control comparison (Lip Tint Implora®) an IC50 value of 1,98 µg/mL was obtained. The formula with a concentration of 10% has an IC50 value of 1,62 µg/mL in the very strong category.
FORMULATION OF BRIGHTENING GEL WITH ETANOL EXTRACT OF RED PAWPAW LEAVES (Syzygium oleana) AS ANTIOXIDANT Suryanita; Alfiani Am, Fenni; Asri SR, Muhammad; junita, Nurfitria
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

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Excessive sun exposure can have a negative impack on the skin. One way that can be done to reduce this impact is to use sunscreen. This research aimed to determine whether the ethanol of red shoot leaves (Syzygium oleana) can be formulated into a gel preparation that is physically and chemically stable and to determine sunscreen activity based on the SPF value using the UV-VIS spectrophotometric method. The method in this research was laboratory experimental. Red shoot leaves were extracted by using the maceration method with a preparation formula designe in three concentration, namely Formula 1 (1%), Formula 2 (3%),and  Formula 3 (5%). Then a stability test was carried out by storing at temperatures of 40C and 400C. Evaluation of preparation qualityincludes organoleptic, homogeneity, pH, viscosity, and spreadability test. An SPF value test was also carried out. The research results that have been carried out show that the ethanol extract of red shoot leaves with concentration of 1% 3% and 5% formulated in gel form produces a stable preparation and meets the quality requirements of the preparation. The SPF value from formula 1 is 2,508349 (minimal protection), formula 2 3,380475 (minimal protection) and formula 3 2,679704 (minimal protection).
Optimasi Formula Foot Spray Gel Minyak Atsiri Bunga Lavender Dengan Variasi Konsentrasi Carbopol 940 Sebagai Gelling Agent Dirgahayu Yahya, Nurul Fitri; Asri SR, Muhammad; SR, Nurqalbi; Suryanita
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1666

Abstract

ABSTRACT Foot odor is a prevalent issue resulting from excessive perspiration and bacterial proliferation in moist environments. This research aimed to optimize the formulation of a lavender (Lavandula angustifolia Miller.) essential oil foot spray gel by varying the concentration of Carbopol 940 as a gelling agent. In this laboratory-based experimental study, three formulations were developed containing 0.3%, 0.5%, and 0.7% Carbopol 940. Evaluations involved organoleptic assessment, homogeneity, pH measurement, viscosity testing, spreadability, adhesion, and stability evaluation through cycling tests. All formulations fell within the skin’s pH range (4.5–6.5) and demonstrated good homogeneity. Findings indicated that higher Carbopol 940 concentrations increased viscosity while reducing spreadability. The 0.5% Carbopol 940 formulation provided the optimal balance between viscosity, spreadability, and physical stability. Cycling test results confirmed that this formulation remained stable without notable changes in physical characteristics. It is concluded that the optimal lavender essential oil foot spray gel formulation was achieved at a Carbopol 940 concentration of 0.5%. Keywords: Carbopol 940, foot spray gel, lavender, essential oil
Antibacterial Activity Test of Anti-Acne Gel Preparations Containing Ethanol Extracts of Bidara Arab Leaf (Ziziphus spina-christi (L.) Desf) Againts Propionibacterium acnes Muzayyidah; Asri SR, Muhammad; Riska Safitri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 02 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.184 KB) | DOI: 10.58549/pcjn.v2i01.61

Abstract

Bidara arab leaf (Ziziphus spina-christi (L.) Desf) is one of the plants that have the potential as an anti-acne. The content of secondary metabolites contained in bidara arab leaves include alkaloids, polyphenols, flavonoids, saponins, and tannins. These secondary metabolites can inhibit the growth of acne causing bacteria, namely Propionibacterium acnes. The purpose of this study was to create a good gel dosage form of the ethanol extract of bidara arab leaves and to test the antibacterial activity of the gel formulation against Propionibacterium acne. This research method was carried out experimentally on a laboratory scale, namely ethanol extract of bidara arab leaves made in the form of anti-acne gel preparations with several concentration, including F1(1%), F2 (3%), and F3 (5%). Then proceed with the evaluation of the preparation with organoleptic test, homogenity test, pH test, adhesion test, and dispersion test. Anti-acne gel preparations had antibacterial activity based on a concentration of 1% of 12.46 mm (strong), 3% of 13.66 mm (strong), and 5% of 14.71 mm (strong), negative control had no inhibition zone and positive control 20.92 mm (very strong). strong) So, it can be included that the formulation of anti-acne gel preparations able to inhibit the growth of Propionibacterium acnes.
Co-Authors Alfiani Am, Fenni Dahlia Dirgahayu Yahya, Nurul Fitri Gisela Junita, Nurfitria Muzayyidah Riska Safitri Sadsyam, Sriyanty SR, Nurqalbi Sudirman, Agriawan Suryanita Wali, Putri