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All Journal Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti Journal of Health Sciences and Epidemiology
Shihran, Laviany Putri
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PENENTUAN JENIS PELARUT TERBAIK TERHADAP KADAR EURYCUMANONE PADA EKSTRAKSI AKAR PASAK BUMI (EURYCOMA LONGIFOLIA JACK) Setyaningrum, Dyah; Wulansari, Laela; Andayani, Andayani; Shihran, Laviany Putri; Fauziyyah, Isra; malik, kirana
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 2, Juli 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i2.17217

Abstract

Pasak bumi (Eurycoma longifolia Jack) adalah salah satu tanaman herbal dari negara-negara Asia Tenggara yaitu Indonesia, Malaysia, dan Vietnam. Bagian tanaman yang memiliki khasiat adalah bagian daun, akar dan batang. Berbagai macam senyawa kimia telah diisolasi dan dikarakterisasi dari Eurycoma longifolia, serta diketahui memiliki berbagai efek yang menguntungkan seperti male fertility enhancement effect, antimalarial effect, cytotoxic and anti-proliferative effect, antimicrobial effects, anti-inflammatory effects, anti-anxiolytic, anti diabetic, osteoporosis preventive effect, ameliorative effect, ergoganic effect, insecticidal effects, muscular effect, antiulcer effect dan anti-rheumatism effect. Tanaman ini sangat potensial untuk digunakan dalam produk farmasi herbal. Komposisi senyawa kimia dari tumbuhan adalah esensial untuk penentuan kualitas, keamanan dan efektifitas dari produk herbal. Penelitian ini dilakukan untuk mengetahui kandungan eurycomanone pada ekstrak akar pasak bumi, serta mengetahui pelarut terbaik dalam proses ekstraksi dari akar pasak bumi yang menghasilkan kadar eurycomanone tertinggi. Metode pembuatan ekstrak dengan cara melakukan maserasi simplisia akar pasak bumi menggunakan pelarut etanol 30%, etanol 70%, etanol 96%, n-heksana, etilsetat dan air. Tahap awal penelitian dimulai dengan melakukan uji fitokimia dan uji kadar air pada simplisa. Selanjutnya pada masing-masing ekstrak dilakukan uji toksisitas terhadap larva udang serta penentuan kadar eurycomanone dengan High-performance liquid chromatography (HPLC). Hasil rendemen ekstrak pasak bumi tertinggi terdapat pada ekstrak dengan menggunakan pelarut etanol 70% sebesar 3.41 g. Hasil pengujian fitokimia simplisia pasak bumi mengandung flavonoid dan saponin. Toksisitas tertinggi terdapat pada ekstrak dengan menggunakan pelarut etilasetat dengan nilai LC50 sebesar 201.28 ppm. Ekstrak pasak bumi dengan pelarut etanol 70% memiliki kadar eurycomanone tertinggi yaitu 53.42 mg/g.
Analysis of Risk Factors for Acute Respiratory Infection in Terms of The Physical Environment in Jatimulya Village Shihran, Laviany Putri; Sinaga, Evi Susanti
Journal of Health Sciences and Epidemiology Vol. 1 No. 1 (2023): April 2023
Publisher : RRZ Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62404/jhse.v1i1.8

Abstract

Acute respiratory infection (ARI) is currently a global primary health problem. WHO 2016 data shows that the incidence of ARI and the under-5 mortality rate are estimated at >40/1000 live births, or 15%-20% per year in the under-five group. ARI is an inflammatory reaction in the upper or lower respiratory tract. The risk of ARI occurring depends on three factors: the individual, behaviour, and environmental conditions. Environmental factors include lighting, humidity, area of ventilation or windows, types of walls, floors, roofs, and the distance from the house to the main road. Environmental factors, especially the house’s physical condition, are closely related to the magnitude of the community's risk of ARI. This study used a cross-sectional design. It was carried out in October 2022 and involved 148 mothers with toddlers in Jatimulya Village, Bekasi Regency. The instruments used were a rolling meter, a hygrometer, and a questionnaire with univariate and bivariate analysis. A chi-square test was used to determine whether there was a relationship. From the analysis results, it was found that the window width (p = 0.000) and humidity (p = 0.000) were related to the incidence of ARI, and the results were not related to the type of house wall (p = 0.069), the type of floor of the house (p = 0.196), and the distance between the house and the main road (p = 0.144) with the incidence of ARI. There is a significant relationship between window width and humidity and the incidence of ARI in toddlers, but there is no significant relationship between the type of wall, the type of floor, or the distance from the house to the main road.
Co-Authors Andayani Andayani Evi Susanti Sinaga Fauziyyah, Isra Malik, Kirana Siti Helmyati Wulansari, Laela