Prohibited item detection in X-ray security screening is a challenging task due to the diverse shapes, sizes, and materials of concealed objects. In this paper, we propose a novel end-to-end framework, integrating adaptive multiscale convolution blocks (AMC Block) and an adaptive lightweight convolution module (ALCM), to address these challenges with high accuracy and efficiency. The AMC block leverages parallel convolutional paths with varying kernel sizes and dilation rates, enabling the capture of both fine-grained and large-scale features. This multiscale strategy ensures that small items like wires and larger objects such as bags or metallic weapons are equally well-detected. Building on top of multi-stage features extracted by the AMC block, we introduce the ALCM to refine and fuse feature maps at different pyramid levels. The ALCM employs a dynamic weight generator (DWG), which adaptively assigns importance to multiple convolutional kernels based on local content, followed by multi-scale depthwise convolutions (MSDC), a lightweight mechanism that enriches features across scales using parallel convolutions with different receptive fields. This approach enhances spatial context while keeping the parameter overhead minimal. Experimental results on two public large-scale X-ray datasets, OPIXray and HiXray, demonstrate that our method achieves state-of-the-art performance while maintaining real-time inference speed. Specifically, our model achieves 91.2% mAP@0.5 and 78.4% mAP@0.5:0.95 on OPIXray, and 87.3% mAP@0.5 and 73.5% mAP@0.5:0.95 on HiXray, outperforming strong baselines including YOLOv9 and Faster R-CNN. Despite competitive accuracy, our model remains efficient with 92.0 GFLOPs and 42 FPS. Furthermore, we examine the generalizability of our system across varied X-ray imaging settings and discuss failure cases such as false negatives in cluttered environments. These findings highlight the practical applicability of our approach for deployment in real-world security checkpoints, striking a strong balance between detection accuracy and computational efficiency.