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All Journal Agrofarm, Jurnal Agroteknologi Jurnal Tumbuhan Obat Indonesia
Rosidah, Eva Hana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health

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Increasing Artemisinin Content on Artemisia Plants Through Endophytic Bacteria Inoculation as An Effort to Support the Availability of Malaria Drugs : Peningkatan Kandungan Artemisinin pada Tanaman Artemisia Melalui Inokulasi Bakteri Endofit Sebagai Upaya Mendukung Ketersediaan Obat Malaria Yuliani, Farida; Nureida, Fadila Rona; Fairuzia, Fazat; Rosidah, Eva Hana; Nugroho, Agung Wahyu; Amiroh, Afifatul
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1155

Abstract

In 2020, malaria cases worldwide increased from 219 million cases to 241 million cases with 627 thousand deaths. This creates problems in terms of the availability of malaria drugs. In addition, resistance to Plasmodium sp. against the commonly used malaria drug chloroquine is another problem. Therefore, in the treatment of malaria, combination-based treatment with artemisinin is highly recommended. However, there are obstacles in the production of artemisinin because its content in plants is relatively low. Therefore, this research aims to increase artemisinin content using endophytic bacteria. The method used is a factorial design with 2 factors, namely Accessions (Green & Purple) and endophytic bacteria concentration (0%, 1%, and 2%). Endophytic bacteria isolated from artemisinin plants were first cultured in a nutrient-rich medium to increase their population. Then, they were inoculated by spraying them twice a week for two months with each accession in each treatment combination. The results showed that inoculation with endophytic bacteria had the best concentration in increasing artemisinin content, namely 1% in green and purple Artemisia accessions. Artemisinin inoculation of 1% was able to increase artemisinin by 27.85% compared to control plants in green Artemisia and purple Artemisia accessions with an increase of 32.89% compared to control plants. The best concentration of endophytic bacteria in increasing artemisinin content is 1%.
FRUIT PEEL ECOENZYMES AND BIOSAKA AS EFFICIENT AND EFFECTIVE NUTRIENTS IN ORNAMENTAL PLANTS USING AQUEOUS MEDIA Rosidah, Eva Hana; Fairuzia, Fazat; Putri, Cindy Elisa; Yuliani, Farida; Mahfudloh, Zumi; Farhanah, Maulina
Agrofarm: Jurnal Agroteknologi Vol. 4 No. 1 (2025): AGROFARM (JURNAL AGROTEKNOLOGI)
Publisher : Faculty of Agriculture and Business, Universitas Mahasaraswati Denpasar , Kec. Denpasar Utara, Kota Denpasar, Bali 80233

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/agrofarm.v4i1.11461

Abstract

Air pollution from toxic exhaust gases from various human activities, such as the remains of motor vehicles, factories, and even gas released by organic waste, is dangerous for human health, especially the lungs. To minimise the impact of air pollution, ornamental plants such as Epipremnum aureum with efficient care and water media are considered, especially for urban areas. Nutrition is the main factor in plant growth, so striving for safe organic nutrients is necessary. The ecoenzymes and biosaka effectively promote plant growth and are safe for human health. The research was carried out with a complete randomised block experimental design with one factor, the type of nutrient solution, consisting of three levels: control in the form of water, ecoenzyme solution 1 mL L-1 water, and biosaka solution 1.5 mL L-1 water, with six replications. The research showed that the highest results were significant in the number of shoots, shoot length, and root number of Epipremnum aureum were influenced by the biosaka solution, followed by the ecoenzyme solution and the control, respectively. Adding biosaka and ecoenzyme solutions can become an efficient and effective source of nutrients in the planting medium, and using water will minimise air pollution.
Increasing Artemisinin Content on Artemisia Plants Through Endophytic Bacteria Inoculation as An Effort to Support the Availability of Malaria Drugs : Peningkatan Kandungan Artemisinin pada Tanaman Artemisia Melalui Inokulasi Bakteri Endofit Sebagai Upaya Mendukung Ketersediaan Obat Malaria Yuliani, Farida; Nureida, Fadila Rona; Fairuzia, Fazat; Rosidah, Eva Hana; Nugroho, Agung Wahyu; Amiroh, Afifatul
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1155

Abstract

In 2020, malaria cases worldwide increased from 219 million cases to 241 million cases with 627 thousand deaths. This creates problems in terms of the availability of malaria drugs. In addition, resistance to Plasmodium sp. against the commonly used malaria drug chloroquine is another problem. Therefore, in the treatment of malaria, combination-based treatment with artemisinin is highly recommended. However, there are obstacles in the production of artemisinin because its content in plants is relatively low. Therefore, this research aims to increase artemisinin content using endophytic bacteria. The method used is a factorial design with 2 factors, namely Accessions (Green & Purple) and endophytic bacteria concentration (0%, 1%, and 2%). Endophytic bacteria isolated from artemisinin plants were first cultured in a nutrient-rich medium to increase their population. Then, they were inoculated by spraying them twice a week for two months with each accession in each treatment combination. The results showed that inoculation with endophytic bacteria had the best concentration in increasing artemisinin content, namely 1% in green and purple Artemisia accessions. Artemisinin inoculation of 1% was able to increase artemisinin by 27.85% compared to control plants in green Artemisia and purple Artemisia accessions with an increase of 32.89% compared to control plants. The best concentration of endophytic bacteria in increasing artemisinin content is 1%.
Co-Authors Agung Wahyu Nugroho, Agung Wahyu Amiroh, Afifatul Fairuzia, Fazat Farhanah, Maulina Farida Yuliani Mahfudloh, Zumi Nureida, Fadila Rona Putri, Cindy Elisa