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All Journal Jurnal Ilmu Kefarmasian Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Putri, Indah Prasetya
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation Between C-Reactive Protein and Blood Sugar Profile and Lipid Profile in Obesity After Lifestyle Modification for 3 Months Putri, Indah Prasetya; Santi Syafril
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 2 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i2.9591

Abstract

Background. C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein that participates in the systemic response to inflammation and its plasma concentration increases during inflammatory states. The purpose of the study was to determine the correlation between CRP and blood sugar profile and lipid profile in obesity undergoing lifestyle modification for 3 months. Method. The study was conducted on hospital nurses with BMI >25 (obesity) who were selected voluntarily. Before making lifestyle modifications (diet and physical exercise) for 3 months, patients are given lighting, understanding, and training on lifestyle modifications. Patients were examined for BMI, FPG, PPG, HbA1c, LDL, HDL, and ApoB before and after 3 months of lifestyle modification. Result. Lifestyle modification for 3 months had been performed on 20 patients with a BMI of 30.9±4.15 kg /m2 (obesity). There is a significant correlation between CRP and PPG, HbA1C, LDLC, and ApoB (p < 0.005). Conclusion. There is a significant correlation between CRP and glucose profile and lipid profile on obesity undergoing lifestyle modification for 3 months.
Anticancer activity of Stichopus vastus extract against MCF-7 and HeLa cells from Natuna waters Sukmiwati, Mery; Nurjanah, Nurjanah; Diharmi, Andarini; Putri, Indah Prasetya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1631

Abstract

Sea cucumbers (Stichopus vastus) contain bioactive compounds with potential anticancer properties, making them a promising alternative raw material for pharmaceutical development. This study aimed to isolate and fractionate bioactive compounds from S. vastus and evaluate their anticancer activity against MCF-7 and HeLa cell lines. Isolation was performed using Thin Layer Chromatography (TLC), and cytotoxic activity was assessed in vitro using the MTT assay. Phytochemical screening revealed the presence of steroids, terpenoids, and saponins. IC₅₀ values were calculated through linear regression analysis. The methanol extract exhibited IC₅₀ values of 13.50 µg/mL (HeLa) and 17.25 µg/mL (MCF-7), indicating active anticancer potential. The n-hexane fraction showed IC₅₀ values of 10.09 µg/mL (HeLa) and 15.11 µg/mL (MCF-7), also categorized as active. Notably, the ethyl acetate fraction demonstrated superior activity, with an IC₅₀ of 7.00 µg/mL against HeLa (very active) and 13.32 µg/mL against MCF-7 (active). These findings suggest that the ethyl acetate fraction of S. vastus holds significant promise as an anticancer agent, particularly against HeLa cells.
Co-Authors Andarini Diharmi Mery Sukmiwati N. Nurjanah Santi Syafril