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All Journal Science Midwifery Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Farmasi Indonesia
Ledianasari, Ledianasari
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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FORMULASI SEDIAAN BIODEGRADABLE FILM DENGAN BASIS KAPPA KARAGENAN HASIL VARIASI SULFATASI UNTUK PENGOBATAN LUKA BAKAR Ferdiansyah, Rival; Ledianasari, Ledianasari; Rachmaniar, Revika; Rumbaman, Gaina Nurfauziah
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 12, No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v12i2.218

Abstract

Kappa karagenan memiliki kandungan ester sulfat sekitar 25% hingga 30% dan kandungan 3,6-AG sekitar 28% hingga 35%. Kandungan sulfat  merupakan salah satu faktor yang mempengaruhi karakteristik fisik kappa karagenan, seperti viskositas, gel strength dan elastisitas. Karagenan jenis ini dapat digunakan sebagai basis dalam pembuatan biodagradble  film untuk aplikasi penutup luka bakar. Tujuan penelitian ini ialah untuk mengetahui pada konsentrasi berapakah kappa karagenan hasil variasi sulfatasi menggunakan  K2SO4 0.2M; 0.4M dan 0.6M menghasilkan biodagradble  film yang baik berdasarkan karakteristik fisiknya. Tahapan penelitian yang dilakukan meliputi formulasi dan evaluasi bentuk sediaan. Hasil pengujian organoleptis, bobot dan tebal, menunjukkan bahwa Formula 1; Formula 4 dan Formula 7 memiliki hasil yang optimal dibandingkan dengan formula lainnya. Ketiga formula tersebut dilakukan uji lanjutan yaitu tensile strength, swelling dan difusi. Formula 7 memiliki hasil paling optimal dibandingkan formula lainnya dengan nilai tensile strength 3,964 MPa, elongasi 171.3% dan kemampuan menyerap air sebesar 40.487% serta memiliki kemampuan berdifusi paling besar yaitu 45.424% pada menit ke 360. Kata Kunci: kappa karagenan, kandungan sulfat, sulfatasi, Biodegradable film
Variasi Konsentrasi Maltodekstrin Terhadap Karakteristik Fisik dan Aktivitas Antibakteri Orally Disintegrating Film Ekstrak Daun Pecut Kuda (Stachytarpheta jamaicencis L.) Putri, Yola Desnera; Ledianasari, Ledianasari; Aziza, Farradiba Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 14 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1153.857 KB) | DOI: 10.35617/jfionline.v14i2.79

Abstract

Abstract: Orally dissolving film (ODF) preparations are a new invention that allows drugs to be used more conveniently than other oral solid preparations without the need for drinking water. Porterweed (Stachytarpheta jamaicencis L) is one of herbal medicine that can be developed into an Orally Disintegrating Film (ODF) preparation with providing fast disintegration time and convenience comsumption especially for patients who have difficulty swallowing tablets. Main component in ODF preparations is polymer. Combination of HPMC K100M and maltodextrin produce good physical characteristics. The research was aimed to determine the influence of variations concentration 3.5 grams, 4.5 grams and 5.5 grams of maltodextrin on the physical characteristic of ODF containing porterweed extract. Stages of research carried out the formulation of basis and preparations continued with physical evaluated and antibacterical activity. To ensure that the resulting ODF preparations are ideal, evaluation tests need to be carried out including organoleptic, pH of the preparations, average weight, thickness, swelling index, disintegration time, tensile strength, percent elongation, and antibacterial activity. The best physical characterictis evaluation is formula 2 of ODF porterweed extract (Stachytarpheta jamaicencis L) containing 4.5 grams of maltodextrin with pH surface 6.75 ± 0.025, average weight 0.0499 ± 0.0001 g, thickness 0.0997 ± 0.002 mm,  swelling index in 15;30; and 45 sec. are 257.49 ± 0.244%; 322.46 ± 0.202%; and 403.21 ± 0.197%, disintegration time in 54 sec., tensile strength 12.67± 0.374 MPa, percent elongation 20% and have strong category of antibacterial ability against Staphylococcus aureus in 11.43 ± 1.401 mm.
Formulation and antibacterial activity of black mulberry fruit (Morus nigra L.) extract cream against cutibacterium acnes and staphylococcus epidermidis Putri, Yola Desnera; Munawaroh, Lisna; Ledianasari, Ledianasari; Andriyannto, Adit
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2338

Abstract

Acne vulgaris is an inflammatory disorder of the pilosebaceous unit characterized by sebum overproduction, abnormal keratinization, microbial proliferation, and inflammation, with Propionibacterium acnes and Staphylococcus epidermidis as key contributing bacteria. To reduce the side effects associated with conventional acne therapies, natural ingredients have been explored as alternative approaches. Black mulberry (Morus nigra) fruit is one such natural source known to contain bioactive compounds, including flavonoids, tannins, and terpenoids, which possess antibacterial properties. This study aimed to develop and evaluate a topical cream formulation containing ethanolic extract of black mulberry fruit and to assess its antibacterial activity and physicochemical stability. The extract was obtained through 96% ethanol maceration and formulated into creams at concentrations of 1.25%, 2.5%, and 5%. Antibacterial activity was evaluated using the agar well diffusion method, while cream quality was assessed through organoleptic properties, homogeneity, pH, viscosity, spreadability, and centrifugation stability. The results showed that the extract exhibited strong antibacterial activity against both tested bacteria. All concentrations demonstrated inhibition zones categorized as strong, with a concentration-dependent increase in activity. At 1.25% inhibition zones against P. acnes were 11.7 ± 0.25 m, while against S. epidermidis were 11.9 ± 0.20 mm at day 28. All formulations showed acceptable physicochemical characteristics and remained stable during 28 days of storage. The novelty of this study lies in the development of a stable topical cream formulation of M. nigra extract with confirmed antibacterial activity, providing a potential plant-based alternative for anti-acne therapy.
Co-Authors Andriyannto, Adit Aziza, Farradiba Nur Ferdiansyah, Rival Munawaroh, Lisna Rachmaniar, Revika Rumbaman, Gaina Nurfauziah Yola Desnera Putri