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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Ilmiah Medicamento Generics: Journal of Research in Pharmacy Acta Holistica Pharmaciana Generics : Journal of Research in Pharmacy
Dhrik, Mahadri
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Medicine & Pharmacology Public Health Other

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Journal : Jurnal Ilmiah Medicamento

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Evaluasi Kesesuaian Dosis dan Interaksi Obat Potensial pada Pasien Gagal Ginjal Kronik di Rumah Sakit Swasta Denpasar Bali Ratnasari, Pande Made Desy; Dhrik, Mahadri; Rizqy, Laili Kurnia Rizqy; Devi, Ni Kadek Dwi Rosita
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9143

Abstract

End-Stage Renal Disease (ESRD) is a chronic disease with a high mortality rate and increasing prevalence. Patients often experience complications from hemodialysis (HD) and comorbid conditions, leading to treatment complexity and polypharmacy. These factors increase the risk of drug-related problems, including inappropriate dosing and drug interactions. This study evaluated dose appropriateness and potential drug interactions in ESRD patients. The study employed a cross-sectional design involving 96 ESRD patients at the HD Clinic of a private hospital in Denpasar. Data collection was conducted in May 2021 using a data collection instrument based on medical records and purposive sampling techniques. Inclusion criteria included ESRD patients with or without complications and comorbidities, aged ≥18 years, and receiving ≥3 medications. Pregnant or breastfeeding patients were excluded. Dose adjustments were determined using the Cockcroft-Gault equation and therapeutic guidelines, while drug interactions were assessed using Stockley's Drug Interactions, Drug Interaction Facts, Drug Information Handbook, IBM Micromedex®, and Medscape®. The results showed that most patients were aged 45-59 years (46.88%), male (68.75%), had hypertension complications (42.31%), and had comorbid dyslipidemia (55.56%). Most patients received 5-7 drugs (40.62%), primarily vitamins (18.06%), administered once daily (38.26%) and orally (71.26%). A total of 23 prescriptions (23.96%) required dose adjustment, and 53.12% of prescriptions had potential drug interactions, mainly pharmacodynamic (82.72%), with moderate severity (87.65%) and risk category C (82.72%). Pharmacists' roles in reviewing prescriptions should be enhanced to prevent or minimize drug-related problems.
Co-Authors Agustina Nila Yuliawati Arini, Heny Dwi Darmiati, Ni Komang Ari Devi, Ni Kadek Dwi Rosita Dhinata, I Putu Prasna Hilwa, Ulfanni Kadek Duwi Cahyadi Prasetya, A.A. N. Putra Riana Putu Dian Marani Kurnianta Ratnasari, Pande Made Desy Riana Prasetya, Anak Agung Ngurah Putra Rizqy, Laili Kurnia Rizqy Sintya, Dewa Ayu Tri Sutrisna, Nyoman Gede Wulandari, Ni Putu Diah