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All Journal JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Communications in Science and Technology Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.)
Munandar, Nurharis
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Chemistry Education Engineering

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Journal : Communications in Science and Technology

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Green synthesis of copper oxide (CuO) nanoparticles using Anredera cordifolia leaf extract and their antioxidant activity Munandar, Nurharis; Kasim, Syaharuddin; Arfah, Rugaiyah; Basir, Djabal Nur; Hala, Yusafir; Zakir, Muhammad; Natsir, Hasnah
Communications in Science and Technology Vol 7 No 2 (2022)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.7.2.2022.1004

Abstract

Our present study describes the green synthesis of copper oxide nanoparticles (CuONPs) using a leaf extract from Anredera cordifolia (AC). The presence of flavonoids, saponins, and alkaloids in the plant extract was confirmed by phytochemical analysis, and these chemicals can be used as reducing, stabilizing, and capping agents. UV-Vis Spectrophotometry, XRD, FT-IR, and SEM-EDS were used to characterize the CuONPs. The UV-Vis spectroscopy of the biosynthesized CuONPs revealed an absorption peak at 325 nm. The XRD graph also revealed that the Debye-Scherrer formula observed an average crystalline size of around 43.47 nm. EDS analysis confirmed the composition and purity of CuONPs. The presence of functional groups -OH, C=O, and C-O triggers the synthesis of CuONPs, according to FT-IR analysis. Furthermore, the CuONPs antioxidant property inhibited free radicals as antioxidants with an IC50 value of 34.20 g/mL.
Synthesis of Cu Nanoparticles using Anredera cordifolia Extract and their Potential as Antidiabetic with Alpha Amylase Enzyme Inhibition Munandar, Nurharis; Aritonang, Henry F.; Bonaventura, Ridho; Wijaya, Dwi Putra
Communications in Science and Technology Vol 10 No 2 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.2.2025.1829

Abstract

This study reports a green synthesis of copper nanoparticle using binahong (Anredera cordifolia) leaf extract as both a bioreductant and a capping agent. The synthesis was optimized by varying the extract-to-precursor ratio (1:3, v/v) and the reaction pH (6–11) with pH 10 selected as the optimal condition for nanoparticle preparation. Nanoparticle formation was confirmed using UV–Vis spectroscopy, showing a strong absorption band at 325 nm, indicative of oxide-based copper nanostructures and/or surface oxidation during green synthesis. XRD patterns revealed Cu2O as the dominant crystalline phase, characterized by reflections at 2θ ≈ 29.6°, 36.4°, 42.3°, 61.3°, 73.5°, and 77.3°, with a possible minor contribution from metallic Cu due to peak overlap. FTIR spectra confirmed the presence of biomolecules (O–H and C–H bands, along with carbonyl/COO−-related bands) involved in nanoparticle stabilization, as well as Cu–O vibrations around 600–620 cm−1 consistent with Cu2O. PSA showed a dominant hydrodynamic size in the 60–70 nm range (average 65 nm), whereas SEM indicated aggregation into micrometer-scale clusters upon drying. In vitro α-amylase inhibition assays demonstrated concentration-dependent inhibition, with CuNPs (IC50 6.18 μg/mL) and the extract + CuNPs mixture (IC50 6.83 μg/mL) approaching that of acarbose (IC50 5.04 μg/mL) and exhibiting stronger activity than the extract alone (IC50 8.89 μg/mL). The key contribution of this work is the development of a simple, aqueous, environmentally friendly route that leverages local biological resources while producing Cu2O-rich nanoparticles with α-amylase inhibitory activity approaching that of acarbose. These findings highlight the promise of a low-cost antidiabetic candidate for postprandial glucose control and provide a basis for further investigations into nanoformulation and preclinical evaluation.
Co-Authors Arfah, Rugaiyah Bonaventura, Ridho Chairil Anwar Djabal Nur Basir Dwi Putra Wijaya Hasnah Natsir Henry Aritonang Hutagalung, Fajar Hutagalung, Fajar Y.S.T. Muhammad Zakir Syaharuddin Kasim Yusafir Hala