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All Journal Berkala Ilmiah Kedokteran Duta Wacana Jurnal Widya Medika Cermin Dunia Kedokteran
Zevanya, Evita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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MATERNAL AGE INCREASES THE RISK OF DOWN SYNDROME: A CASE-CONTROL STUDY IN YOGYAKARTA, INDONESIA Zevanya, Evita; Indrarto, Wikan; Lestari, Dewi; Widagdo, The Maria Meiwati
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i1.636

Abstract

Background: Down syndrome incidence increases year to year and ranks first in birth defect cases in Indonesia. Down syndrome birth may burden family physically, socially, economically, and emotionally. The most common risk factor associated to Down syndrome is maternal age. Objective: This research is conducted to understand the association between maternal age and parity as the risk factors of Down syndrome births. Methods: Analytical observation design with case-control approach is used in this study. Bivariate and multivariate analysis were calculated using Chi-Square and binary logistic regression test. Results: This research’s results showed significant association between maternal age as risk factor with the incidence of Down syndrome (p-value < 0.001) and no significant association between parity with the incidence of Down syndrome (p-value > 0.05) in Yogyakarta, Indonesia. Mothers aged ? 35 years have 18.82 greater risk to give birth Down syndrome baby compared to mothers aged < 35 years (OR=18.82). The mean of maternal age when birth Down Syndrome children was 35.1 years old. Biological ovarium aging hypothesis presumed cause higher probability of chromosomal segregation failure during oocyte meiosis. Advanced maternal age naturally causes biological ovarium aging. Biological ovarium aging may caused or influenced by hormonal imbalance, limited oocyte pool, oxidative stress, change of spontaneous abortus mechanism, and genetic abnormality or mutation. No significant association between parity with the incidence of Down Syndrome (p-value=0.0689). Conclusion: Mothers with age of 35 year or older are the only the risk factor for having child with Syndrome Down in this research, with 18.82 more greater risk than mothers under 35 years old. The mean of maternal age when birth Down Syndrome children was 35.1 years old.
BIRTH LENGTH AS STUNTING RISK FACTOR IN TODDLERS: A STUDY IN JLEGONG VILLAGE, JEPARA REGENCY, CENTRAL JAVA PROVINCE, INDONESIA Lisa Jessica; Fx Wikan Indrarto; Suryanto, Yanti Ivana; Zevanya, Evita
JURNAL WIDYA MEDIKA Vol. 11 No. 1 (2025): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v11i1.7252

Abstract

Stunting is a children growth and development disorder caused by complex interaction of poor nutrition, infection, socio-economic factors, and the absence of adequate environmental stimuli. Stunting incidence in Indonesia is still high, including in Jlegong Village, Keling District, Jepara Regency, Central Java Province, Indonesia. Stunting will impact children’s quality of life, intellectual abilities, health, and productivity which affect the country's economy. The risk factors of stunting are health services, inadequate nutrition, environmental, genetics, and a history of chronic disease. Research about risk factors of stunting has never been carried out in Jlegong village. The aim of this study is to identify risk factors of stunting of toddlers in Jlegong village. The study design was an observational cross-sectional using total sampling. Bivariate analysis was calculated with Chi-square test and multivariate with Fisher's Exact Test. The result showed significant association between birth length with stunting (p-value = 0.001, OR = 19.33). Toddlers who had short birth length (< 50 cm) had 19.33 times higher risk of stunting than toddlers with normal birth length (≥ 50 cm). There was no significant association between birth weight, exclusive breastfeeding, maternal height, frequency of antenatal care visit, the latest level of education of parents with stunting.
POST-OPERATIVE SIMPLE INCOMPLETE ACQUIRED SYNDACTYLY IN THIRD AND FOURTH DIGITI MANUS SINISTRA: A CASE REPORT Zevanya, Evita; Zacharias, Samuel
JURNAL WIDYA MEDIKA Vol. 10 No. 1 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i1.5602

Abstract

Syndactyly is interdigiti soft tissue and/or osseous fusion or adhesion and may affect hand and/or foot. Syndactyly is caused by congenital or acquired. Acquired syndactyly is a rare disease that may caused by trauma, inflammation, or infection around the finger. This abnormality may affect aesthetic and functional impairment, so that surgery procedure is needed to syndactyly release. The aim of this paper is to report a rare case of simple incomplete acquired syndactyly post-operative in a man aged 53 year old. Patient came to surgery clinic because adhesion of his third and fourth left hand fingers since 21 years ago. The abnormality was disturbing his work as a baker currently. He had trauma 21 years ago when he worked as construction labour that cause swelling in his left palm, so he went to hospital and got needle aspiration. After needle aspiration, he experienced worse symptoms like recurrency swelling, rednesss, itchy, and pain then got surgery procedure that did not affect the fingers area directly. After surgery, the symptoms got improved, but he found adhesion between his third and fourth fingers days later after surgery. From currently physical examination, there was left hand interdigiti adhesion between 1/3 proximal thirth and forth fingers and from palpation there was no adhesion between the finger bone. He was diagnosed simple incomplete acquired syndactyly third and fourth digiti manus sinistra. The patient got surgery procedure with z-plasty technique to syndactyly release and hospitalized for 3 days. He got Cefixime, Ketoprofen, and Mefenamic Acid when he went home. The patient came to hospital to get follow-up 6, 10, and 17 days after surgery. Keywords: Simple incomplete acquired syndactyly; post-operative; case report.
Sindrom Down: Skrining, Diagnosis, dan Konsekuensi Kesehatan: Tinjauan Pustaka Zevanya, Evita
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1368

Abstract

Down syndrome is congenital or genetic abnormality with extra chromosome 21 causing various clinical manifestations and health problem. Down syndrome ranked first as the most common cause of birth defect in Indonesia. Chromosomal abnormality cause Down syndrome children have a higher risk and more common health problems. Down syndrome can burden family or caregiver physically, socially, financially, and emotionally. Proper screening and diagnosis criteria need to be done to establish the diagnosis.
Co-Authors Dewi Lestari Fx Wikan Indrarto Indrarto, Wikan Lisa Jessica Suryanto, Yanti Ivana Widagdo, The Maria Meiwati Zacharias, Samuel