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All Journal Jurnal Kedokteran Diponegoro Diponegoro International Medical Journal (DIMJ)
Damayanti, Galih Sari
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Medicine & Pharmacology Neuroscience

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Literature Review: The Role of Saffron (Crocus sativus L) in Cosmetic Dermatology Damayanti, Galih Sari; Riyanto, Puguh
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.40711

Abstract

Background : Crocus sativus L known as saffron is widely discussed in Indonesia. Although saffron has been used since ancient times for medicinal and cosmetic purposes, scientific research on the mechanism of saffron in its role in promoting skin health is lacking. Objectives : This literature review is to determine the role of saffron in cosmetic dermatology. Methods : This article is a narrative research. The library sources that used was carried out through the database Google Scholar, PubMed, and Cochrane. The article search does not limit study design or study level. All articles were searched from 2012 to June 2023. The study inclusion criteria included: data available in English and Indonesian. Exclusion criteria were articles on the benefits of using saffron in the other field of dermatology and the use of saffron in combination with other topical active ingredients. Results : There were 16 articles which meet the criterias. It was found that saffron play role in the cosmetic dermatology such as in skin aging, melasma, as a photoprotection agents, skin moisturizer, prevention and treatment of skin cancer, as well as preparation of cosmetic products. Saffron has antioxidant, antiinflammatory, antipigmentation, antiwrinkle, anticarcinogenic and photoprotective activities. Conclusion : Crocus sativus L is a natural ingredient that has the potential to be further developed into medicinal forms, both oral and topical preparations because it is proven to have various pharmacological effects that play role in the cosmetic dermatology.
THE EFFECT OF DAYAK ONION (ELEUTHERINE PALMIFOLIA) EXTRACT CREAM APPLICATION ON SERUM INTERLEUKIN-6 LEVELS: AN EXPERIMENTAL STUDY IN UVB-INDUCED MALE WISTAR RATS Choirunnisa, Armadina Fitra; Afriliana, Liza; Damayanti, Galih Sari; Widyawati, Widyawati
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29701

Abstract

Background: Indonesia receives intense ultraviolet B (UVB) exposure. Prolonged exposure to (UVB) radiation is a major environmental factor contributing to oxidative stress and skin inflammation through the overproduction of reactive oxygen species (ROS) and subsequent upregulation of pro-inflammatory cytokines, including interleukin-6 (IL-6). Eleutherine palmifolia, traditionally used in Indonesian herbal medicine, contains abundant flavonoids and phenolic compounds with documented antioxidant and photoprotective properties. Its ability to absorb UV rays and neutralizing ROS suggests potential efficacy as a topical agent for mitigating UVB-induced inflammatory responses. Objective: This study aimed to evaluated the effect of Eleutherine palmifolia extract cream at various concentrations (10%, 15%, 20%) on serum IL-6 levels in UVB-induced male Wistar rats. Methods: A true experimental design with post-test only control group was conducted using 36 male Wistar rats randomly assigned to four groups: control (placebo), P1 (10%), P2 (15%), and P3 (20%). The cream was applied 20 minutes before UVB exposure and again 4 hours after irridation, three times per week for 30 days. Serum IL-6 levels were measured using ELISA. Statistical analysis was performed using Shapiro–Wilk, Levene’s test, one-way ANOVA, and LSD post-hoc test. Results: Mean IL-6 levels (pg/mL): control 1.63; P1 1.59; P2 1.65; P3 1.57. ANOVA indicated a significant differences among groups (p = 0.047). Post-hoc analysis showing a significant difference only between P2 and P3 groups (p = 0.012). Conclusion: The 20% Eleutherine palmifolia cream showed the strongest anti-inflammatory effect, significantly lowering IL-6 compared with 15%, while other group differences were not significant.
Effect of Topical Dayak Onion (Eleutherine palmifolia) Cream on Epidermal Thickness in UVB-Exposed Male Wistar Rats: An Experimental Study Setyanegari, Aditya Putri; Damayanti, Galih Sari; Afriliana, Liza; Karlowee, Vega
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29621

Abstract

Background: Exposure to ultraviolet B (UVB) radiation, particularly in tropical regions like Indonesia, can cause skin damage characterized by increased epidermal thickness due to keratinocyte hyperproliferation, contributing to photoaging. Natural photoprotective agents rich in antioxidants such as Dayak onion (Eleutherine palmifolia) extract are expected to mitigate these effects. Objective: This study aims to evaluate the effect of applying Dayak onion extract cream at varying concentrations on epidermal thickness of UVB-induced male Wistar rat skin. Methods: This study was a true experimental study with a post-test only control group design. A total of 36 male Wistar rats were randomly divided into four groups: a control group (given placebo cream) and three treatment groups given Dayak onion extract cream at concentrations of 10%, 15%, and 20%. UVB exposure was carried out every two days for 30 days, along with application of the cream before and after UVB radiation. Epidermal thickness was analyzed through histopathological examination using Hematoxylin-Eosin staining and observed under 400x magnification. Results: Statistical analysis showed significant differences (p < 0,05) in epidermal thickness between the control group and the treatment groups. The mean epidermal thickness in the treatment groups was lower than that of the control group, with the greatest reduction observed in the 20% concentration group, followed by the 15% and 10% groups. There was no significant difference between the 15% and 20% concentrations. Conclusion: Application of Dayak onion extract cream is effective in reducing epidermal thickness, with a concentration of 20% providing optimal protective effects. These findings support the potential of Dayak onion as a natural photoprotective agent.Keywords: Dayak onion, Eleutherine palmifolia, epidermal thickness, photoaging, antioxidant
Co-Authors Afriliana, Liza Choirunnisa, Armadina Fitra Karlowee, Vega Puguh Riyanto Setyanegari, Aditya Putri Widyawati Widyawati