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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Medica Hospitalia
Damayanti, Galih Sari
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Literature Review: The Role of Saffron (Crocus sativus L) in Cosmetic Dermatology Damayanti, Galih Sari; Riyanto, Puguh
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.40711

Abstract

Background : Crocus sativus L known as saffron is widely discussed in Indonesia. Although saffron has been used since ancient times for medicinal and cosmetic purposes, scientific research on the mechanism of saffron in its role in promoting skin health is lacking. Objectives : This literature review is to determine the role of saffron in cosmetic dermatology. Methods : This article is a narrative research. The library sources that used was carried out through the database Google Scholar, PubMed, and Cochrane. The article search does not limit study design or study level. All articles were searched from 2012 to June 2023. The study inclusion criteria included: data available in English and Indonesian. Exclusion criteria were articles on the benefits of using saffron in the other field of dermatology and the use of saffron in combination with other topical active ingredients. Results : There were 16 articles which meet the criterias. It was found that saffron play role in the cosmetic dermatology such as in skin aging, melasma, as a photoprotection agents, skin moisturizer, prevention and treatment of skin cancer, as well as preparation of cosmetic products. Saffron has antioxidant, antiinflammatory, antipigmentation, antiwrinkle, anticarcinogenic and photoprotective activities. Conclusion : Crocus sativus L is a natural ingredient that has the potential to be further developed into medicinal forms, both oral and topical preparations because it is proven to have various pharmacological effects that play role in the cosmetic dermatology.
Anti-Inflammatory and Photoprotective Potential of Clitoria ternatea Extract in Mitigating UV-B-Induced IL-1β Elevation Damayanti, Galih Sari; Kresnantio, Febryan Fadhil; Mahadewa, Narendra Lintang; Nursyafillah, Rizki Noval; Fany, Alfa Sofia
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.31148

Abstract

ABSTRACTBackground: Global climate change has escalated ultraviolet (UV) radiation exposure, contributing to skin aging and damage. Ultraviolet radiation, especially UV-B, is a known inducer of reactive oxygen species (ROS), which trigger inflammation and accelerate photoaging by increasing IL-1, IL-6, IL-8, and TNF-α levels. Clitoria ternatea, or butterfly pea, contains bioactive phytochemicals such as flavonoids and anthocyanins, known for their antioxidant and anti-inflammatory properties.Objective: This study aims to evaluate the effects of C. ternatea extract cream on serum IL-1β levels in UV-B-induced Wistar rats, exploring its potential in reducing photoaging and promoting skin health.Methods: True experimental study with post-test only control group design involving male Wistar rats for 30 days. The rats were divided into four groups: negative control with placebo (base cream) and treatment groups given 2.5%, 5%, and 10% C. ternatea extract cream, with UV-B induction applied for 30 minutes, three times per week. IL-1β were evaluated using ELISA Rat IL-1 kit.Results: Significant differences were observed between the negative control and extract-treated groups. The lowest IL-1β levels were recorded in the 2.5% and 5% extract groups (p<0.001), indicating a strong anti-inflammatory effect. The findings suggest that C. ternatea extract cream, especially at 2.5% and 5% concentrations, effectively reduces IL-1β levels in UV-B-induced Wistar rats. The bioactive compounds in C. ternatea, such as anthocyanins and flavonoids, may inhibit ROS production and inflammation pathways. This study demonstrates that C. ternatea extract cream can reduce IL-1β levels, potentially mitigating UV-induced skin damage.Conclusion: The C. ternatea extract’s anti-inflammatory properties make it a promising candidate for skincare products aimed at reducing photoaging. Further studies are recommended to explore the effects of higher concentrations and long-term applications in clinical settings. Keywords: Clitoria ternatea extract, IL-1β modulation, antiphotoaging, photoprotective agents, herbal skincare.                                                   
Relationship between Serum Interleukin-6 Level and Severity of Acne Vulgaris in Women Falika, Najwa Luna; Setyawati, Amallia Nuggetsiana; Kusumaningrum, Novi; Damayanti, Galih Sari
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 2 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i2.1403

Abstract

BACKGROUND:  Acne vulgaris is more common in women than men and is observed more frequently in older adolescents than younger adolescents (pre-teens). This is due to higher sebum production, which supports the growth of Propionibacterium acnes. Propionibacterium acnes contributes to initiating and maintaining inflammatory processes induced by immunological reactions. It activates the Toll-like receptor (TLR) 2 and 4 immune systems by releasing interleukin-6 (IL-6) as a core mediator of inflammation. AIMS: This study aims to determine the relationship between serum IL-6 levels and the severity of acne vulgaris in women METHOD: This research employs an analytical observational study design with a cross-sectional approach, involving 15 female subjects diagnosed with acne vulgaris, divided into three groups. The study will occur in Semarang city from July 2024 to September 2024.RESULT:  This study involved 15 female students from Diponegoro University, categorized based on the severity of acne vulgaris (mild, moderate, severe). Blood samples were taken to measure serum IL-6 levels using the ELISA method. The average IL-6 levels found were: mild 1.00 ± 0.55 pg/ml, moderate 1.47 ± 0.27 pg/ml, and severe 1.99 ± 0.42 pg/ml. Analysis revealed a significant relationship between serum IL-6 levels and the severity of acne vulgaris (p = 0.011), supporting the hypothesis of a correlation between the two.CONCLUSION: There is a significant relationship between serum IL-6 levels and the severity of AV in women. There is a meaningful difference in serum IL-6 levels between the mild and severe AV groups.
Co-Authors Amallia Nuggetsiana Setyawati Falika, Najwa Luna Fany, Alfa Sofia Kresnantio, Febryan Fadhil Kusumaningrum, Novi Mahadewa, Narendra Lintang Nursyafillah, Rizki Noval Puguh Riyanto