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All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia JSFK (Jurnal Sains Farmasi & Klinis)
Satrialdi, Satrialdi
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Studi Disolusi Terbanding dari Tablet Febuxostat dengan Variasi Perbandingan Konsentrasi Hidroksipropil Selulosa dan Natrium Kroskarmelos Hambali, Luthfi Fathiinah; Soewandhi, Sundani Nurono; Satrialdi, Satrialdi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.47328

Abstract

Febuxostat merupakan obat golongan anti asam urat, obat ini adalah turunan 2-arylthiazole yang bekerja dengan menurunkan kadar serum asam urat dengan penghambatan secara selektif pada xanthine oxidase (XO). Dalam beberapa penelitian yang telah dilakukan sebelumnya menunjukkan bahwa Febuxostat memiliki efikasi dan keamanan yang lebih baik dibandingkan Allopurinol. Febuxostat masih merupakan obat yang menjanjikan untuk dikembangkan di Indonesia dikarenakan berdasarkan data Badan Pengawas Obat dan Makanan (BPOM) hingga saat ini hanya terdapat  1 kompetitor obat copy generic berlogo yang beredar. Uji disolusi terbanding merupakan pengujian secara in vitro untuk membuktikan  similaritas obat copy yang dibandingkan terhadap produk innovator, dimana similaritas tersebut merupakan salah satu syarat registrasi obat, suatu obat copy dinyatakan similar terhadap produk innovator bila hasil perhitungan F2 pada uji disolusi terbanding > 50%. Uji disolusi terbanding dilakukan pada 3 pH yaitu 1,2; 4,5; dan 6,8. Pada penelitian ini dilakukan pengembangan tablet Febuxostat dengan beberapa perbandingan konsentrasi hidroksipropil selulosa (HPS) dan natirum kroskarmelos (NKK). Desain percobaan dibuat dengan desain faktorial penuh menggunakan aplikasi Minitab 21. Konsentrasi hidroksipropil selulosa dioptimasi pada konsentrasi 3 dan 5% sedangkan natrium kroskarmelose dioptimasi pada konsentrasi 1 dan 4%.   HPSNKKTujuan dari penelitian ini adalah menemukan kombinasi HPS HPSdanNKK NKK yang tepat, untuk menghasilkan produk tablet yang memenuhi uji disolusi terbanding pada ketiga pH. Berdasarkan hasil penelitian, konsentrasi HPSNKK HPS : NKK (3:1) menghasilkan uji disolusi terbanding yang similar di ketiga pH, dimana nilai similaritas pada pH 1,2; 4,5; dan 6,8 berturut-turut sebesar 65,62; 74,72; dan 80,82. 
Development of Oil Vehicle Screening Method for Bromo Acid Dye-Based Color-Changing Cosmetic Formulation Susanto, Eriwan; Cita, Juang Arwafa; Sujilah, Ajeng Rana Wulan; Satrialdi, Satrialdi; Suciati, Tri; Nugraha, Yuda Prasetya
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.67-79.2024

Abstract

Bromo acid dye (Red 21) recently gained attention in the production of color-changing cosmetics. The critical aspect in the development of cosmetic products using this dye group is the compatibility of its oil vehicles. The compatibility of bromo acid dyes with oil vehicles is determined by several parameters such as the dye solubility in the oils, clarity of the mixture, and the ability to change color when the pH of the solution is adjusted to match the skin’s pH. Therefore, this study conducted the compatibility study by examining the ability of 27 oil samples to dissolve Red 21. The ability of a vehicle to dissolve a compound is influenced by the polarity of the vehicle. Hence, a correlation was established between the relative polarity of oils and their ability to dissolve Red 21. The results showed that the water-oil interfacial tension was negatively correlated (r = -0.64) with Red 21 solubility in the oil. From this research, the water-oil interfacial tension represented the relative polarity of the oil and was considered sufficient to predict the compatibility of the oil with Red 21. In addition, hydrocarbon and silicone oils are not compatible with Red 21.
Formulasi dan Karakterisasi Minyak Atsiri Pala (Myristica fragrans) di Dalam Sistem Nanostructured Lipid Carrier Satrialdi, Satrialdi; Fadilah, Alinda Nur; Rahma, Annisa
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24776

Abstract

Essential oil extracted from nutmeg (Myristica fragrans) contains various beneficial compounds that can be used in medicines and cosmetics. Nevertheless, nutmeg essential oil (NEO) use in pharmaceuticals is limited by its high lipophilicity and tendency to degrade. Encapsulating NEO into a nanostructured lipid carrier (NLC) can be an alternative to overcome these problems. Thus, this study aimed to develop an NEO formula in an NLC system (NEO-NLC) for topical use, to characterize NEO-NLC, and to elucidate its potential as an antioxidant. The optimization of the NEO-NLC formula included selecting liquid lipid components, adjusting their ratios, choosing a sonicator, selecting a surfactant system, and optimizing sonication amplitude. The optimum NEO-NLC formula was then characterized by determining particle size and distribution, measuring zeta potential, estimating encapsulation efficiency, and evaluating antioxidant activity. The optimum NEO-NLC formula was obtained with a composition of 1.8% cetyl alcohol, 3.0% almond oil, 1.2% NEO, 3.2% Tween 80, 0.8% Plantacare® 1200, and demineralized water. The resulting NEO-NLC exhibited a particle size of 124.4 ± 4.7 nm, a polydispersity index of 0.35 ± 0.05, a zeta potential of -39.0 ± 3.6 mV, and an encapsulation efficiency of 95.3 ± 0.6%. Encapsulation of NEO into an NLC system resulted in a 2.9-fold increase in antioxidant activity compared to unencapsulated NEO. The developed NEO-NLC showed potential for pharmaceutical or cosmetic raw material use.
Co-Authors Cita, Juang Arwafa Fadilah, Alinda Nur Hambali, Luthfi Fathiinah Nugraha, Yuda Prasetya Rahma, Annisa Sujilah, Ajeng Rana Wulan Sundani Nurono Soewandhi Susanto, Eriwan Tri Suciati