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All Journal Indonesian Journal of Pharmaceutical Science and Technology Prosiding University Research Colloquium
Ningrum, Nur Faizah Setya
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Humanities Computer Science & IT Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Antidiabetic activity of matoa leaves (Pometia pinnata J.R.Forst & G. Forst) extract on hyperglycaemic alloxan-induced rats Wahyuni, Arifah Sri; Muflihah, Cita Hanif; Fadhilah, Arini; Oksaputra, Amar Khoiri; Ningrum, Nur Faizah Setya; Bakhtiar, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.33711

Abstract

Matoa (Pometia pinnata J.R.Forst & G. Forst) leaves contain polyphenols and flavonoids which areprospective for the development of the new antidiabetic agent. This research aimed to explore thepotency of matoa leaves in reducing blood glucose level and increasing plasma insulin concentrationin alloxan-induced rats. The experimental study was done in 6 treatment groups: the aquadest (normal),alloxan (Alx) 150 mg/kgBW (negative control), glibenclamide (Gli) 5 mg/kgBW (positive control),and matoa leaves extract (MLE) at the doses of 50, 100, and 200 mg/kgBW. The treatment wasadministered for 14 days orally post-induction of alloxan and fasting blood glucose (FBG) reached>200 mg/dL. Blood glucose levels were established by the GOD-PAP (Diasys) method while plasmainsulin was measured using Rat insulin ELISA kit. Hematoxyline-eosin (HE) staining on tissues wasperformed to observe the population of pancreatic beta cells. The results showed that the MLE extractat a dose of 200 mg/kgBW could decrease the FBG level to 135.25±21.14 mg/dL and increase theplasma insulin level up to 0.14%. Pancreas histopathology indicated that the number of damaged cellswere lower than negative control. In conclusion, our results affirm the promising potential of MLE asa candidate of the novel antidiabetic agent.
Pengaruh Pemberian Ekstrak Etanol 50% Daun Matoa (Pometia pinnata J.R.Forst & G.Forst) Terhadap Kadar Glikogen Hati Tikus Putih Jantan Hiperglikemik Ningrum, Nur Faizah Setya; Wahyuni, Arifah Sri
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Mahasiswa (Student Paper)
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ekstrak etanol 50% daun matoa atau EEDM (Pometiapinnata J.R.Forst & G.Forst) dengan kandungan berupa flavonoidyang memiliki aktivitas antioksidan mampu menetralkan radikalbebas dengan meregenerasi sel ? pankreas dalam memproduksihormon insulin. Penurunan kadar gula darah disebabkan karenakelebihan gula disimpan dalam bentuk glikogen dengan bantuanhormon insulin. Penelitian ini bertujuan untuk menetapkan pengaruhekstrak etanol 50% daun matoa atau EEDM (Pometia pinnataJ.R.Forst & G.Forst) terhadap kadar glikogen hati pada tikuspercobaan yang diinduksi aloksan 150 mg/kgBB. Penelitianeksperimental dilakukan dengan RAL (Rancangan Acak Lengkap)terhadap 6 kelompok perlakuan yang diberi perlakuan denganakuades tanpa induksi, akuades, glibenklamid 5 mg/kgBB, dan tigakelompok EEDM dengan dosis 50, 100, dan 200 mg/kgBB EEDMselama 14 hari. Kadar glikogen ditetapkan dengan metode antronmenggunakan hati tikus yang telah dikeringkan. Hasil dari penelitianmenunjukkan bahwa EEDM dosis 50 dan 100 mg/kgBB mampumeningkatkan kadar glikogen hati yang tidak berbeda signifikan(sama) dengan kelompok tikus kontrol positif yang diberikanglibenklamid dosis 5 mg/kgBB.
Co-Authors Arifah Sri Wahyuni Bakhtiar, Muhammad Cita Hanif Muflihah Fadhilah, Arini Oksaputra, Amar Khoiri