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All Journal Indonesian Journal of Pharmaceutical Science and Technology Abdi Geomedisains Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy
Fadhilah, Arini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antidiabetic activity of matoa leaves (Pometia pinnata J.R.Forst & G. Forst) extract on hyperglycaemic alloxan-induced rats Wahyuni, Arifah Sri; Muflihah, Cita Hanif; Fadhilah, Arini; Oksaputra, Amar Khoiri; Ningrum, Nur Faizah Setya; Bakhtiar, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.33711

Abstract

Matoa (Pometia pinnata J.R.Forst & G. Forst) leaves contain polyphenols and flavonoids which areprospective for the development of the new antidiabetic agent. This research aimed to explore thepotency of matoa leaves in reducing blood glucose level and increasing plasma insulin concentrationin alloxan-induced rats. The experimental study was done in 6 treatment groups: the aquadest (normal),alloxan (Alx) 150 mg/kgBW (negative control), glibenclamide (Gli) 5 mg/kgBW (positive control),and matoa leaves extract (MLE) at the doses of 50, 100, and 200 mg/kgBW. The treatment wasadministered for 14 days orally post-induction of alloxan and fasting blood glucose (FBG) reached>200 mg/dL. Blood glucose levels were established by the GOD-PAP (Diasys) method while plasmainsulin was measured using Rat insulin ELISA kit. Hematoxyline-eosin (HE) staining on tissues wasperformed to observe the population of pancreatic beta cells. The results showed that the MLE extractat a dose of 200 mg/kgBW could decrease the FBG level to 135.25±21.14 mg/dL and increase theplasma insulin level up to 0.14%. Pancreas histopathology indicated that the number of damaged cellswere lower than negative control. In conclusion, our results affirm the promising potential of MLE asa candidate of the novel antidiabetic agent.
UJI AKTIVITAS IMUNOMODULATOR EKSTRAK METANOL BUAH KECOMBRANG (Etilngera elatior (Jack) R.M.Smith) TERHADAP RESPON IMUN SPESIFIK PADA MENCIT Husada, Dani Fahri; Fadhilah, Arini
Usadha Journal of Pharmacy Vol. 4 No. 2 (2025): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v4i3.537

Abstract

Kecombrang (Etlingera elatior (Jack) R.M.Smith) adalah tanaman dari famili Zingiberacea yang terdapat di Indonesia khususnya daerah Sulawesi, Sumatera dan Jawa. Di daerah Konawe Sulawesi Tenggara buah kecombrang disebut dengan nama buah wualae oleh masyarakat buah ini biasanya dijadikan sebagai bahan tambahan dalam masakan. Selain itu, bukti empiris di kabupaten Kolaka Utara Sulawesi Tenggara, buah kecombrang digunakan sebagai obat demam tifoid karena diyakini dapat membantu dalam pemulihan. Senyawa bioaktif yang terkandung dalam buah antara lain yaitu alkaloid, flavonoid, saponin dan minyak atsiri yang juga bermanfaat sebagai antioksidan. Penelitian ini bertujuan untuk menetapkan aktivitas imunomodulator ekstrak metanol buah kecombrang terhadap respon imun spesifik pada mencit. Metode yang digunakan pada penelitian ini adalah hemaglutinasi pengukuran titer antibodi. Dosis ekstrak metanol buah kecombrang yang digunakan secara per oral yaitu 25, 50, dan 100 mg/kgBB dengan perlakuan selama 12 hari. Hasil titer antibodi menunjukkan bahwa ekstrak metanol buah kecombrang kontrol positif memiliki nilai titer 1:1024 lebih tinggi dibandingkan dengan kelompok kontrol negatif 1:128. Hasil uji skrining fitokimia menunjukkan bahwa sampel ekstrak metanol buah kecombrang (Etlingera elatior (Jack) R.M. Smith) mengandung senyawa alkaloid, flavonoid, dan tanin. Berdasarkan hasil penelitian menunjukkan bahwa ekstrak metanol buah kecombrang (Etlingera elatior (Jack) R.M. Smith) dosis 25, 50, dan 100 mg/kgBB memiliki aktivitas imunomodulator sebagai imunostimulan dengan tingkat sedang terhadap respon imun mencit.
Pencegahan dan Pengendalian Diabetes Melitus Melalui Pilihan Nutrisi dan Diet Pada Ibu-Ibu PKK Desa Batan, Banyudono, Boyolali Haryoto; Fadhilah, Arini; Fauzi, Ahmad
Abdi Geomedisains Vol. 6, No. 1, June 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/abdigeomedisains.v6i1.10597

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease with an increasing prevalence due to unhealthy lifestyles and limited public knowledge, including among PKK women in Batan Village, most of whom do not yet understand how to choose healthy foods to prevent and manage DM. This community service program aimed to improve the understanding of PKK members in Batan Village, Banyudono, Boyolali, regarding DM management through proper nutrition and dietary education. The activities were carried out in three stages: fasting blood glucose screening, nutrition counseling, and interactive discussions. Among the 21 participants, 42.86% showed fasting blood glucose levels exceeding 110 mg/dL. The educational materials emphasized the selection of foods with a low glycemic index and the avoidance of foods high in added sugars. The discussion sessions revealed that most participants initially lacked understanding of DM prevention; however, after the program, around 85% of participants were able to mention foods recommended for DM patients and understood the concept of portion control. The education was also contextualized by promoting local food ingredients such as sweet potatoes and peanuts. This program demonstrated that a community-based educational approach can be an effective non-pharmacological strategy to reduce the risk of DM and improve community quality of life, as evidenced by the increase in participants’ understanding, with 85% able to mention recommended foods for DM patients and understand portion control concepts after the education. Simple direct educational interventions proved successful in building significant preventive health awareness.
Efektivitas Penyembuhan Luka Bakar Derajat II Sediaan Gel Ektrak Buah Belimbing Wuluh (Averroa bilimbi L.) Terhadap Tikus Jantan Galur Wistar Astuti , Dina Puji; Fadhilah, Arini
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.847

Abstract

Burns are lesions on body tissues that occur due to exposure to heat sources such as fire, chemicals, or electric currents. Bilimbi (Averroa bilimbi L.) is thought to have therapeutic properties to treat burns in male Wistar rats. Burn healing is divided into 3 phases of inflammation, proliferation, and maturation. This study was to prove the ability of the ethanol extract gel preparation of bilimbi in the process of healing burns. Bilimbi extract gel was formulated in three concentration variations, namely 2.5%, 5%, and 10%. Control testing of the preparation included organoleptic, homogeneity, spreadability, viscosity, and adhesion. The bilimbi extract gel preparation with a series of concentrations of 2.5%, 5%, and 10% gave an effect in healing second-degree burns. The percentage data of burn diameter were analyzed using ANOVA. The results of statistical analysis showed that the preparation of ethanol extract gel from star fruit with a concentration of 10% gave a healing effect with a healing percentage of 86% which was almost the same as the positive control. This healing effect is thought to come from the content of star fruit such as alkaloids, flavonoids, saponins.
Co-Authors Arifah Sri Wahyuni Astuti , Dina Puji Bakhtiar, Muhammad Cita Hanif Muflihah Fauzi Ahmad Muda Haryoto Husada, Dani Fahri Ningrum, Nur Faizah Setya Oksaputra, Amar Khoiri