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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Sains dan Komunitas
Aktifa, Ana Fadilia
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Computer Science & IT Medicine & Pharmacology

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The Impact of Variations in The Concentration of Wungu Leaf Extract (Graptophyllum Pictum (L.) Griff) Upon The Physical Properties of Sunscreen Spray Preparations Aktifa, Ana Fadilia; Rahmayanti, Mayu; Amalina, Faidatul
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.43542

Abstract

Sunscreen is applied to the skin to protect it from UV rays. Wungu leaves (Graptophyllum pictum (L.) Griff), which are rich in flavonoids and exhibit antioxidant activity, are one of the substances that can be used to create sunscreen formulations. The purpose of this research is to determine how varying concentrations of wungu leaf extract affect the physical qualities of sunscreen spray formulations. This research method involves extraction, extract assessment (organoleptic, yield, and water content), formulation with different extract concentrations (500 ppm, 1,000 ppm, and 1,500 ppm), and physical evaluation (organoleptic, homogeneity, pH, viscosity, and spraying pattern). Data analysis use linear regression equations in the software Microsoft Excel. All formulations with different extract quantities yielded green, transparent, liquid, homogenous solutions with a pronounced smell of wungu leaf extract. The results of pH and viscosity tests on formulations including diverse extracts satisfied the requirements for topical spray preparations, with pH and viscosity values sequentially dropping (Formulas 1, 2, and 3) with slope values of -0.43 and -4.835, respectively. The results of the spray pattern test indicate an oval to circular spread with increased diameter values in the extract variation and slope values of 0.55, 0.568, 0.6685, and 0.4865 at spraying distances of 3, 5, 10, and 15 cm, respectively. On the basis of the study's findings, it can be inferred that differences in the content of wungu leaf extract have an effect on the physical properties of spray sunscreen formulations, as measured by pH, viscosity, and spray pattern diameter.
Design, Formulation, and Evaluation of Vitamin C Tablets Using Co-Processed Excipient Combination of Jackfruit Seed Starch and Avicel®️ PH 101 Rahmayanti, Mayu; Dewi, Tanaya Jati Dharma; Aktifa, Ana Fadilia; Paramitha, Sella; Nikmah, Rahayu Hikmatul; Septianshar, Lumen Muzaidi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008319

Abstract

Tablet is a popular pharmaceutical dosage form among the public. One method of making tablets is direct compression. This method must consider the flow properties and compressibility of the excipients. But many excipients do not meet these criteria, leading to the alternative use of co-processed excipients of jackfruit seed starch and avicel®️ PH 101. This research aims to determine the physical characteristics of direct compression vitamin C tablets using co-processed excipient of PBN-A (Jackfruit Seed Starch and Avicel®️ PH 101) with varying ratios of 1:3, 3:1, and 1:1. The research methods include powder preparation, powder evaluation, tablet compression, and physical evaluation of tablet. Descriptive and statistical data analysis using one-way ANOVA. The research results show that tablets exhibit favorable physical characteristics in F1, but F2 and F3 show suboptimal hardness and friability values. The statistical analysis results indicate a significant difference with a p-value of (0.000) and post-hoc tests explain that these significant differences are particularly noticeable between F1 and F2, K1, and K2. This study concludes that vitamin C tablets using co-processed excipients of PBN-A with ratios of 1:3, 3:1, and 1:1 exhibit good physical characteristics in all evaluations, except for the hardness and friability of F2 (3:1) and the hardness of F3 (1:1).
Co-Authors Amalina, Faidatul Mayu Rahmayanti Nikmah, Rahayu Hikmatul Paramitha, Sella Septianshar, Lumen Muzaidi Tanaya Jati Dharma Dewi