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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology
Amalina, Faidatul
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Chemistry Computer Science & IT Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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The Impact of Variations in The Concentration of Wungu Leaf Extract (Graptophyllum Pictum (L.) Griff) Upon The Physical Properties of Sunscreen Spray Preparations Aktifa, Ana Fadilia; Rahmayanti, Mayu; Amalina, Faidatul
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.43542

Abstract

Sunscreen is applied to the skin to protect it from UV rays. Wungu leaves (Graptophyllum pictum (L.) Griff), which are rich in flavonoids and exhibit antioxidant activity, are one of the substances that can be used to create sunscreen formulations. The purpose of this research is to determine how varying concentrations of wungu leaf extract affect the physical qualities of sunscreen spray formulations. This research method involves extraction, extract assessment (organoleptic, yield, and water content), formulation with different extract concentrations (500 ppm, 1,000 ppm, and 1,500 ppm), and physical evaluation (organoleptic, homogeneity, pH, viscosity, and spraying pattern). Data analysis use linear regression equations in the software Microsoft Excel. All formulations with different extract quantities yielded green, transparent, liquid, homogenous solutions with a pronounced smell of wungu leaf extract. The results of pH and viscosity tests on formulations including diverse extracts satisfied the requirements for topical spray preparations, with pH and viscosity values sequentially dropping (Formulas 1, 2, and 3) with slope values of -0.43 and -4.835, respectively. The results of the spray pattern test indicate an oval to circular spread with increased diameter values in the extract variation and slope values of 0.55, 0.568, 0.6685, and 0.4865 at spraying distances of 3, 5, 10, and 15 cm, respectively. On the basis of the study's findings, it can be inferred that differences in the content of wungu leaf extract have an effect on the physical properties of spray sunscreen formulations, as measured by pH, viscosity, and spray pattern diameter.
Optimization of nanoemulsion hair serum from chia seed oil using the Simplex Lattice Design method Rahmayanti, Mayu; Oktavia, Reza Putri; Amalina, Faidatul; Fadila, Safa Aulia Nur; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27936

Abstract

Hair loss is a hair problem that men and women often experience. Chia seed oil (Salvia hispanica L.) contains linolenic acid, which can stimulate the sebum glands. This research aims to determine the composition of the optimum formula for chia seed oil nanoemulsion hair serum using the Simplex Lattice Design (SLD) method to prove that the characteristics and physical stability of the optimum formula meet the requirements for good preparation. The optimization method was carried out with the help of Design Expert 13 software to optimize the formula by varying Tween 80 (X1) and propylene glycol (X2). The characteristic parameters observed include organoleptic parameters such as pH, viscosity, homogeneity, emulsion type, particle size, zeta potential, polydispersity index, and percent transmittance. The physical stability test was carried out using a 6-cycle test method for organoleptic parameters, pH, and homogeneity. Optimization results show that the optimum composition consists of Tween 80 33.52% and propylene glycol 46.48%. The preparation meets all physical characteristic tests. Physical stability did not significantly change in the pH test, with a significance value of 0.027 in the paired t-test. Based on the research results, it can be concluded that the optimum surfactant and cosurfactant composition in the optimum formula based on optimization using SLD is Tween 80 (33.52%) and propylene glycol (46.48%) with a desirability value of 0.947. The optimum formula for preparing chia seed oil nanoemulsion hair serum meets good physical characteristics and stability requirements.
Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method Amalina, Faidatul; Rahmayanti, Mayu; Afrizal, Muhammad; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.28081

Abstract

Hair is one of the most essential parts of the human body, both men and women; one of the problems with hair that often occurs is hair loss. Chia plants contain sebum gland-stimulating agents with a keratin protein concentration of 23%. The sebaceous glands play a role in facilitating the growth of hair follicles so that hair can thrive and prevent hair loss. This research aims to determine the optimum composition of the prediction formula using Design Expert software and the physical characteristics and stability of liquid shampoo preparations. Optimization was carried out using Design Expert 13 software with two material components, namely HPMC and SLS, and two responses, namely viscosity and foam height. The optimum formula obtained was subjected to characteristic tests and stability tests. The stability test was carried out using the cycling test method by storing the preparation at temperatures of 4◦C and 40◦C for 48 hours. The results of the prediction formula show that component X1 is 0.589307% and X2 is 9.41069%. The one-sample t-test showed that the results were not significantly different at p>0.05 in the two responses. Testing of the optimum formula's physical characteristics and physical stability meets the reasonable requirements for organoleptic tests, homogeneity tests, viscosity tests 414,80±9,94 cPs, foam height tests 7,060±0,11 cm, and pH tests 7,39±0. The 8th run is the optimum formula with a composition of X1 0.589307% and X2 9.41069 % meets the requirements for good physical characteristics tests and physical stability tests.
Co-Authors Aktifa, Ana Fadilia Fadila, Safa Aulia Nur Ginanjar Putri Nastiti Mayu Rahmayanti Muhammad afrizal Oktavia, Reza Putri Sadli Syarifuddin