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All Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Jamu Indonesia Indonesian Journal of Jamu
Nailus Amany Melinda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Other

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AKTIVITAS ANTIDIABETES BEBERAPA FRAKSI DAUN MIMBA (Azadirachta indica) SECARA IN VITRO BERDASARKAN PENGHAMBATAN ENZIM α-AMILASE Nailus Amany Melinda; Djati Wulan Kusumo; Diah Indah Kumala Sari
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.28301

Abstract

Diabetes mellitus merupakan penyakit yang ditandai dengan adanya peningkatan kadar glukosa darah karena tubuh tidak dapat menghasilkan atau menggunakan insulin dengan baik. Salah satu tanaman herbal yang dapat menurunan kadar glukosa dalam darah adalah tanaman mimba (Azadirachta indica). Daun mimba telah diketahui memiliki senyawa flavonoid yang sangat berpotensi dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui potensi antidiabetes dari fraksi daun mimba (Azadirachta indica) dengan variasi pelarut berbeda dalam menghambat enzim α-amilase. Daun mimba diekstraksi dengan metode maserasi menggunakan metanol kemudian dipartisi cair-cair dengan pelarut n-heksan etil asetat dan metanol. Fraksi n-heksan, etil asetat dan metanol daun mimba yang diperoleh dilakukan skrining fitokimia dan uji in vitro terhadap enzim α-amilase menggunakan substrat pati beras dan reagen dinitrosalisilat (DNS). Penghambatan enzim α-amilase dilakukan dengan variasi konsentrasi sampel yaitu 200; 400; 600; 800 dan 1000 ppm. Analisis data dilakukan secara deskriptif dengan menghitung nilai % inhibisi dan IC50. Hasil penelitian menunjukkan adanya kandungan senyawa alkaloid dan terpenoid pada fraksi n-heksan; flavonoid dan tanin pada fraksi etil asetat; serta flavonoid, tanin, saponin dan alkaloid pada fraksi metanol. Nilai IC50 fraksi etil asetat didapatkan sebesar 54,85 μg/ml dengan kategori kuat dan metanol sebesar 132,26 μg/ml dengan kategori sedang, sedangkan fraksi n-heksan didapatkan nilai penghambatan sebesar 33,82% pada konsentrasi 600 ppm. Fraksi n-heksan tidak dapat diukur nilai IC50nya karena adanya perbedaan polaritas antara fraksi n-heksan dengan enzim α-amilase sehingga tidak dapat bercampur dengan baik. Fraksi etil asetat menunjukkan penghambatan paling tinggi dibandingkan dengan fraksi lainnya.
ARTICLES REVIEW: Ethno-Pharmaceutical Study of Medicinal Plants for Care and Treatment of Wounds in Indonesia: Systematic Data Search and Preclinical Review Kusumo, Djati Wulan; Erlita Layina Sulistiyowati; Habibatur Rohmah; Nailus Amany Melinda
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.232

Abstract

Ethnopharmacy study is an approach used to explore local knowledge of a particular community in the use of medicinal plants. This article discusses treatment methods and medicinal plants used for the treatment and care of wounds in several regions in Indonesia. In addition, this study is also useful to find out drugs from natural ingredients related to their bioactivity. The method used is literature study, while the data used are articles, databases and textbooks published from 2011-2021. Literature information searches are carried out using electronic search engines for articles and research journals published on several sites, such as Google, Pubmed, NCBI, Elsevier, and others. The results of the data obtained concluded that there were 27 types of plant species that were used traditionally and 15 who have already undergone preclinical testing for wound treatment and care.
Ethno-Pharmaceutical Study of Medicinal Plants for Care and Treatment of Wounds in Indonesia: Systematic Data Search and Preclinical Review Kusumo, Djati Wulan; Erlita Layina Sulistiyowati; Habibatur Rohmah; Nailus Amany Melinda
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.232

Abstract

Ethnopharmacy study is an approach used to explore local knowledge of a particular community in the use of medicinal plants. This article discusses treatment methods and medicinal plants used for the treatment and care of wounds in several regions in Indonesia. In addition, this study is also useful to find out drugs from natural ingredients related to their bioactivity. The method used is literature study, while the data used are articles, databases and textbooks published from 2011-2021. Literature information searches are carried out using electronic search engines for articles and research journals published on several sites, such as Google, Pubmed, NCBI, Elsevier, and others. The results of the data obtained concluded that there were 27 types of plant species that were used traditionally and 15 who have already undergone preclinical testing for wound treatment and care.
Co-Authors Diah Indah Kumala Sari Erlita Layina Sulistiyowati Habibatur Rohmah Kusumo, Djati Wulan