Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
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All Journal Archives of The Medicine and Case Reports Community Medicine and Education Journal
Mery Silvia Harahap
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Humanities Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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The Role of Systemic Inflammation in COPD Severity: Insights from FEV1 and hs-CRP Julike, Katarina; Mery Silvia Harahap
Community Medicine and Education Journal Vol. 5 No. 3 (2024): Community Medicine and Education Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/cmej.v5i3.620

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex inflammatory disease characterized by progressive airflow limitation. While pulmonary inflammation is a hallmark, the role of systemic inflammation in COPD severity remains an area of active investigation. This study aimed to explore the relationship between lung function, assessed by Forced Expiratory Volume in 1 second (FEV1), and systemic inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), in patients with stable COPD. A cross-sectional study was conducted involving 51 patients with stable COPD. Lung function was assessed using spirometry, and hs-CRP levels were measured using the Architect tool. The relationship between FEV1 and hs-CRP was analyzed using Spearman's rank correlation test. The study population consisted predominantly of older males (mean age 64.05 ± 8.05 years) with moderate to severe airflow limitation (mean FEV1 33.65 ± 15.78%). All patients had hs-CRP levels within the normal range (<10 mg/L), with a median of 0.34 mg/L. A significant negative correlation was observed between FEV1 and hs-CRP (r = -0.260, p = 0.032), indicating that patients with worse lung function tended to have higher levels of systemic inflammation. The findings suggest that even in stable COPD, systemic inflammation, as reflected by hs-CRP, is associated with lung function impairment. This highlights the potential role of systemic inflammation in COPD progression and underscores the need for further research to elucidate the complex interplay between pulmonary and systemic inflammation in this disease.
Nasopharyngeal Carcinoma in the Nias Tribe Indonesia: Prevalence, Risk Factors, and Characteristics Hana Isal Salina Ginting; Mery Silvia Harahap
Archives of The Medicine and Case Reports Vol. 6 No. 1 (2025): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v6i1.674

Abstract

Nasopharyngeal carcinoma (NPC) is a malignancy with a distinctive racial and geographical distribution, exhibiting a high prevalence in Southeast Asia, including Indonesia. The Nias tribe, an indigenous group in Indonesia, has a particularly high incidence of NPC, which may be linked to unique environmental and genetic factors. This study aimed to investigate the prevalence, risk factors, and characteristics of NPC among the Nias people to inform targeted prevention and control strategies. A retrospective study was conducted on 150 NPC patients treated at a referral hospital in Medan, Indonesia, between 2018 and 2023. Data were collected from medical records, including demographics, clinical presentation, Epstein-Barr virus (EBV) infection status, dietary habits, and environmental exposures. Descriptive statistics and comparative analyses were performed to identify risk factors associated with NPC in the Nias population. The prevalence of NPC among the Nias tribe was 30% (45 out of 150 NPC patients). The majority of Nias patients were male (60%) and aged 40-60 years (70%). EBV infection was prevalent in 80% of the Nias patients. Significant risk factors included consumption of preserved foods (78%), exposure to firewood smoke (65%), and a family history of NPC (20%). Most patients presented with advanced-stage disease (III and IV), with common symptoms such as neck lumps, epistaxis, and nasal obstruction. In conclusion, NPC poses a substantial health burden on the Nias tribe. EBV infection, consumption of preserved foods, exposure to firewood smoke, and genetic predisposition are significant risk factors. Public health interventions should prioritize early detection through EBV screening, health education on risk factors, and promotion of alternative cooking fuels to reduce exposure to carcinogens.
Co-Authors Hana Isal Salina Ginting Julike, Katarina