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Firman, Imran
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Formulation and Evaluation of Anti-Acne Activity of Gel Pineapple Peel (Ananas comosus L.) Extract on the Growth of Propionibacterium acnes Latu, Saparuddin; Firman, Imran; Yaqkin-P, Andi Muh.; Musliani, Musliani
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.286

Abstract

Pineapple peel contains many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, alkaloids and bromelin enzymes. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acne. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the ethanol extract of pineapple peel (Ananas comosus L.) can be made into an anti-acne gel preparation and to find out at what concentration the ethanol extract of pineapple peel (Ananas comosus L.) in an anti-acne gel preparation can provide inhibitory activity on the development of Propionibacterium acne bacteria. This research method is true experimental by making anti-acne gel preparations of pineapple peel extract (Ananas Comosus L.) with various concentrations of 2%, 3%, 5% and testing the activity of the preparation against Propionibacterium acne using the agar well method. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the 5% concentration, namely 12.7 mm, which was in the strong category, while the 3% concentration, which was 11.03 mm, and the 2% concentration, which was 8.8 mm, was included in the moderate category.
Formulasi Dan Uji Stabilitas Sediaan Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa Acuminate Linn) Sebagai Antioksidan Safaruddin; Irmayani; Kalsum, Ummu; Firman, Imran; Amin, Rahmasinar
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 3 No. 2 (2024): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v3i2.246

Abstract

Salah satu tanaman yang dapat dijadikan sebagai obat adalah tanaman Kulit Buah Pisang Muli (Musa Acuminata Linn). Daun dan kulit batang buah pisang muli dimanfaatkan sebagai obat berbagai macam penyakit, seperti pendarahan usus, amandel, memperbaiki pertumbuhan rambut. Kulit Buah Pisang Muli (Musa Acuminata Linn dapat dijadikan sediaan serum Kulit Buah Pisang Muli (Musa Acuminata Linn sebagai antioksidan, metode penelitian dilakukan secara eksperimental laboratorium, ekstrak Kulit Buah Pisang Muli (Musa Acuminata Linn) dimaserasi menggunakan pelarut etanol 96%. Dibuat sediaan serum dengan tiga konsentrasi 3%, 5%, 7%, kontrol negatif K(-), dan kontrol positif K(+) kemudian dilakukan uji organoleptis, homogenitas, pH, daya sebar, viskositas dan cycling test yang dilakukan selama 6 siklus. Hasil uji Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa acuminata Linn) dapat dijadikan sediaan serum yang stabil secara fisika dan kimia serta sediaan Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa Acuminata Linn) memiliki khasiat sebagai antioksidan. Hasil penelitian menunjukkan pada formula I memiliki aktivitas nilai IC50 50,25 µg/mL, formula II memiliki aktivitas nilai IC50 30,96 µg/mL, formula III memiliki aktivitas nilai 7,85 µg/mL, sedangkan control positif memiliki aktivitas nilai IC50 13,35 µg/mL. aktivitas antioksidan dari semua sediaan memiliki sifat antioksidan yang sangat kuat karena <50 ppm kecuali formula II yang memiliki sifat antioksidan kuat karena >50 ppm.
POLA PERESEPAN OBAT GASTRITIS DI PUSKESMAS PANGALE KABUPATEN MAMUJU TENGAH PERIODE JANUARI – AGUSTUS TAHUN 2020 Firman, Imran; Andriani, Cici Dewi
KOLONI Vol. 1 No. 1 (2022): MARET 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i1.9

Abstract

Gastritis is inflammation of the stomach due to increased acid secretion and as a disease mostly found in the society. Based on the results of observations og gastritis at the Pangale Public Health Center, there was is quite high at Central Mamuju Regency. This study aimed to determine prescription patterns of gastritis drugs at Pangale Public Health Centre of Central Mamuju Regency in period January-August 2020. This research was conducted using a descriptive method by collecting data retrospectively on the recipes of gastritis patients. In this study, 103 samples were includedinclusion criteria. The results showed that most gastritis sufferers were women with a percentage of 56.31%, with an age group of 46-55 years (30.10%) and 32.04% SD level education and 42.72% type of occupation. Based on the characteristics, the most frequently drug classes were antacids as much as 79.61% and Antasida Doen were the most widely used drug items (79.61%). The most widely used combination of drugs was antacids + h2-blockers of 47.46%. 100% generic prescription. The accompanying drug, namely vitamin B complex of 46.60% and the dosage form was tablets (98.06%). All drugs used indicate gastritis. Some of the doses were not suitable and the duration of administration was mostly appropriate. The length of giving drugs showed omeprazole for the longest period of 10 days. The rules for using all drugs are given before meals and the most widely used gastritis drugs is Antasida doen with a percenrage of 79.62%. Keywords: Gastritis, drug prescription
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI GEL HAND SANITIZER EKSTRAKETANOL DAUN WARU (Hibiscus tiliaceus L) TERHADAP Escherichia coli DAN Staphylococcus epidermidis Firman, Imran; Sahetapy, Richo
KOLONI Vol. 2 No. 1 (2023): MARET 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v2i1.412

Abstract

Waru leaves have been shown to have antioxidant, anti-inflammatory, antiemetic, and antibacterial properties that are efficacious as a fever reliever, ulcer treatment, and tonsillitis treatment. The purpose of this study was to determine the antibacterial activity as well as to formulate and evaluate antiseptic gel preparations (hand sanitizer) from hibiscus leaf extract (Hibiscus tiliaceus L) against parameters namely organoleptic test, homogeneity test, pH test, viscosity test. The extraction method used is the maceration method using 96% ethanol as solvent. The results of the phytochemical screening study were positive containing flavonoids, tannins, saponins and phenols. Physical stability of hand sanitizer gel preparations ethanol extract of waru leaves (Hibiscus tiliaceus L) effective in inhibiting Staphylococcus epidermidis and Escherichia coli bacteria, the most effective in inhibiting FIII at a concentration of 15% with the resulting inhibition zone value of 17.3 mm for Staphylococcus epidermidis bacteria and 18.8 mm for Escherichia coli bacteria. Keywords : Gel, hand sanitizer, hibiscus leaf, Escherichia coli, Staphylococcus epidermidis
Uji Aktivitas Antibakteri Dan Antijamur Ekstrak Daun Binahong (Anredera cordifolia (Ten) Steenis) Firman, Imran; Iksan, Iksan
KOLONI Vol. 3 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v3i1.604

Abstract

One of the plants that can be used as traditional medicine is binahong leaf (Anredera cordifolia (Ten) Steen). Bioactive subtances from the Binahong plant can help the healing process of disease, research has been carried out on the antibacterial and antifungal activity pf binahong leaf ekstrack (Anredera cordifolia (Ten) Steen). This research is an experimental laboratory aimed at testing the potential antibacterial and antifungal activity of the leaf ekstract of binahong (Anredera cordifolia (Ten) Steen) againts the growth of the bacteria bacillus subtillis s[pan the fungi aspergillus niger. Binahong leaves (Anredera cordifolia (Ten) Steen) Made in the from of a thick ekstrack then carried out phytochemical screening, antibacterial active test using Bacillus Subtillis and shigella sp bacteria also tested for antifungal activity using aspergillus niger fungus. The results showed that the leaf extract of binahong (Anredera cordifola(Ten) Steenins) had antibacterial activity againt bacillus subtillis and shigella sp bacteria at concentrations of 25%, 50%, and 75% by disc method and was in the medium sterong category. And binahong leaf extrac (Anredera cordifolia (Ten) Steen) has antifungal activity againts aspergillus niger at concentrations of 24%, 50%, and 75% by disc method and is in the medium category.
Co-Authors Amin, Rahmasinar Andriani, Cici Dewi Iksan, Iksan Irmayani Musliani, Musliani Safaruddin Sahetapy, Richo Saparuddin Latu Ummu Kalsum Yaqkin-P, Andi Muh.