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All Journal Journal of Physics and Its Applications Indonesian Journal of Cancer
Shafiq, Sunnia
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Astronomy Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Five-Year Analysis of Measured and Calculated Dose Rates from Co60 Teletherapy Machine at Centre for Nuclear Medicine and Radiotherapy (CENAR) Quetta, Pakistan: A Comprehensive Assessment Shafiq, Sunnia; Ahmad, Hafiz Khush Naseeb; Manzoor, Hina; Ur-Rehman, Awais; Naheed, Hameeda; Kanwal, Shagufta; Basit, Abdul; Ullah, Sadiq; Saeed, Hashir; Iftikhar, Shehla
Journal of Physics and Its Applications Vol 6, No 2 (2024): May 2024
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v6i2.21791

Abstract

This study assesses the dosimetry of a Cobalt-60 (Co60) teletherapy unit at the Centre for Nuclear Medicine and Radiotherapy (CENAR), Quetta, to ensure consistent radiation doses for cancer management. Dosimetry measurements were compared against expected outputs derived from the International Atomic Energy Agency's TRS-398 protocol and decay calculations. The current investigation demonstrates uniformity in average output (dose rate) between the actual dosimetry values and the anticipated output values obtained through the International Atomic Energy Agency's TRS-398 (2000) protocol and decay method respectively. The actual dosimetry values fall within a range of ±2% of the estimated values. The difference in measurements acquired through the two approaches falls within acceptable limits as per recommended protocols. Consequently, our study reveals a steady pattern in dose rate, ensuring improved patient dose distribution and minimizing the risk of over or under-dosage.
A Better 3D Conformal Approach in Glioblastoma Proximates Intensity Modulated One: A Dosimetric Study Ullah, Sadiq; Saeed, Hashir; Shafiq, Sunnia; Ahmad, Hafiz Khush Naseeb; Manzoor, Hina
Journal of Physics and Its Applications Vol 7, No 2 (2025): May 2025
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i2.24422

Abstract

This study aimed to evaluate whether Three-Dimensional Conformal Radiation Therapy (3D-CRT) could achieve results comparable to Intensity Modulated Radiation Therapy (IMRT) in treating grade 4 glioblastoma. Treatment plans for 80 consecutive patients with grade 4 glioblastoma, treated between January 1, 2020, and July 31, 2024, were developed using 3D-CRT and IMRT. 3D-CRT utilized three to five fields with dynamic wedges and the field-in-field technique, while IMRT employed seven fields with homogeneous angles. Target coverage was set to ensure that 97% of the isodose covered 98% of the Planning Target Volume (PTV). Both 3D-CRT and IMRT achieved similar target coverage. However, IMRT showed superior homogeneity (0.053 vs. 0.097) and conformity (1.187 vs. 1.663) compared to 3D-CRT. IMRT also provided better sparing of normal brain tissue and surrounding organs, except for the contralateral eye, though it required longer treatment delivery time due to higher Monitor Units (MUs). IMRT additionally limited low-dose escalation. IMRT outperforms 3D-CRT in homogeneity, conformity, and sparing organs at risk, despite the longer treatment time. 3D-CRT may approximate IMRT when the target volume is not near critical structures but still results in greater low-dose exposure to normal brain tissue for the same target coverage.
High-Grade Osteosarcoma Arising in Monostotic Fibrous Dysplasia of the Skull: A Rare Case without Prior Radiation Exposure Iftikhar, Shehla; Shafiq, Sunnia; Kanwal, Shagufta; Manzoor, Hina; Ahmad, Hafiz Khush Naseeb
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1455

Abstract

Introduction: Osteosarcoma is an uncommon, aggressive bone tumor that seldom develops in the skull, particularly when fibrous dysplasia is present, and there has been no previous radiation exposure. In fibrous dysplasia, malignant transformation is usually associated with radiation therapy, McCune-Albright syndrome, or polyostotic illness. Improving patient outcomes requires early diagnosis and action.Case Report: We present a 35-year-old male who developed progressive right mandibular edema and pain. A well-defined lesion with a combination of sclerotic and osteolytic features was seen on imaging. A biopsy revealed fibrous dysplasia and high-grade osteosarcoma coexisting. The patient received adjuvant chemotherapy after surgical resection. The histopathological analysis confirmed the diagnosis, and the surgical process was uneventful. A favorable prognosis was suggested by follow-up evaluations that revealed neither metastases nor local recurrence.Conclusion: This case was reported to highlight the possibility of high-grade osteosarcoma arising from monostotic fibrous dysplasia in the skull, even in the absence of radiation exposure or systemic risk factors, an exceedingly rare but clinically significant occurrence.
Co-Authors Abdul Basit Ahmad, Hafiz Khush Naseeb Iftikhar, Shehla Kanwal, Shagufta Manzoor, Hina Naheed, Hameeda Saeed, Hashir Ullah, Sadiq Ur-Rehman, Awais