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All Journal Journal of Physics and Its Applications
Shafiq, Sunnia
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Astronomy Earth & Planetary Sciences Materials Science & Nanotechnology Physics

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Five-Year Analysis of Measured and Calculated Dose Rates from Co60 Teletherapy Machine at Centre for Nuclear Medicine and Radiotherapy (CENAR) Quetta, Pakistan: A Comprehensive Assessment Shafiq, Sunnia; Ahmad, Hafiz Khush Naseeb; Manzoor, Hina; Ur-Rehman, Awais; Naheed, Hameeda; Kanwal, Shagufta; Basit, Abdul; Ullah, Sadiq; Saeed, Hashir; Iftikhar, Shehla
Journal of Physics and Its Applications Vol 6, No 2 (2024): May 2024
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v6i2.21791

Abstract

This study assesses the dosimetry of a Cobalt-60 (Co60) teletherapy unit at the Centre for Nuclear Medicine and Radiotherapy (CENAR), Quetta, to ensure consistent radiation doses for cancer management. Dosimetry measurements were compared against expected outputs derived from the International Atomic Energy Agency's TRS-398 protocol and decay calculations. The current investigation demonstrates uniformity in average output (dose rate) between the actual dosimetry values and the anticipated output values obtained through the International Atomic Energy Agency's TRS-398 (2000) protocol and decay method respectively. The actual dosimetry values fall within a range of ±2% of the estimated values. The difference in measurements acquired through the two approaches falls within acceptable limits as per recommended protocols. Consequently, our study reveals a steady pattern in dose rate, ensuring improved patient dose distribution and minimizing the risk of over or under-dosage.
A Better 3D Conformal Approach in Glioblastoma Proximates Intensity Modulated One: A Dosimetric Study Ullah, Sadiq; Saeed, Hashir; Shafiq, Sunnia; Ahmad, Hafiz Khush Naseeb; Manzoor, Hina
Journal of Physics and Its Applications Vol 7, No 2 (2025): May 2025
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i2.24422

Abstract

This study aimed to evaluate whether Three-Dimensional Conformal Radiation Therapy (3D-CRT) could achieve results comparable to Intensity Modulated Radiation Therapy (IMRT) in treating grade 4 glioblastoma. Treatment plans for 80 consecutive patients with grade 4 glioblastoma, treated between January 1, 2020, and July 31, 2024, were developed using 3D-CRT and IMRT. 3D-CRT utilized three to five fields with dynamic wedges and the field-in-field technique, while IMRT employed seven fields with homogeneous angles. Target coverage was set to ensure that 97% of the isodose covered 98% of the Planning Target Volume (PTV). Both 3D-CRT and IMRT achieved similar target coverage. However, IMRT showed superior homogeneity (0.053 vs. 0.097) and conformity (1.187 vs. 1.663) compared to 3D-CRT. IMRT also provided better sparing of normal brain tissue and surrounding organs, except for the contralateral eye, though it required longer treatment delivery time due to higher Monitor Units (MUs). IMRT additionally limited low-dose escalation. IMRT outperforms 3D-CRT in homogeneity, conformity, and sparing organs at risk, despite the longer treatment time. 3D-CRT may approximate IMRT when the target volume is not near critical structures but still results in greater low-dose exposure to normal brain tissue for the same target coverage.
Co-Authors Abdul Basit Ahmad, Hafiz Khush Naseeb Iftikhar, Shehla Kanwal, Shagufta Manzoor, Hina Naheed, Hameeda Saeed, Hashir Ullah, Sadiq Ur-Rehman, Awais