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All Journal Journal of Physics and Its Applications Indonesian Journal of Cancer
Kanwal, Shagufta
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Astronomy Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Five-Year Analysis of Measured and Calculated Dose Rates from Co60 Teletherapy Machine at Centre for Nuclear Medicine and Radiotherapy (CENAR) Quetta, Pakistan: A Comprehensive Assessment Shafiq, Sunnia; Ahmad, Hafiz Khush Naseeb; Manzoor, Hina; Ur-Rehman, Awais; Naheed, Hameeda; Kanwal, Shagufta; Basit, Abdul; Ullah, Sadiq; Saeed, Hashir; Iftikhar, Shehla
Journal of Physics and Its Applications Vol 6, No 2 (2024): May 2024
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v6i2.21791

Abstract

This study assesses the dosimetry of a Cobalt-60 (Co60) teletherapy unit at the Centre for Nuclear Medicine and Radiotherapy (CENAR), Quetta, to ensure consistent radiation doses for cancer management. Dosimetry measurements were compared against expected outputs derived from the International Atomic Energy Agency's TRS-398 protocol and decay calculations. The current investigation demonstrates uniformity in average output (dose rate) between the actual dosimetry values and the anticipated output values obtained through the International Atomic Energy Agency's TRS-398 (2000) protocol and decay method respectively. The actual dosimetry values fall within a range of ±2% of the estimated values. The difference in measurements acquired through the two approaches falls within acceptable limits as per recommended protocols. Consequently, our study reveals a steady pattern in dose rate, ensuring improved patient dose distribution and minimizing the risk of over or under-dosage.
High-Grade Osteosarcoma Arising in Monostotic Fibrous Dysplasia of the Skull: A Rare Case without Prior Radiation Exposure Iftikhar, Shehla; Shafiq, Sunnia; Kanwal, Shagufta; Manzoor, Hina; Ahmad, Hafiz Khush Naseeb
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1455

Abstract

Introduction: Osteosarcoma is an uncommon, aggressive bone tumor that seldom develops in the skull, particularly when fibrous dysplasia is present, and there has been no previous radiation exposure. In fibrous dysplasia, malignant transformation is usually associated with radiation therapy, McCune-Albright syndrome, or polyostotic illness. Improving patient outcomes requires early diagnosis and action.Case Report: We present a 35-year-old male who developed progressive right mandibular edema and pain. A well-defined lesion with a combination of sclerotic and osteolytic features was seen on imaging. A biopsy revealed fibrous dysplasia and high-grade osteosarcoma coexisting. The patient received adjuvant chemotherapy after surgical resection. The histopathological analysis confirmed the diagnosis, and the surgical process was uneventful. A favorable prognosis was suggested by follow-up evaluations that revealed neither metastases nor local recurrence.Conclusion: This case was reported to highlight the possibility of high-grade osteosarcoma arising from monostotic fibrous dysplasia in the skull, even in the absence of radiation exposure or systemic risk factors, an exceedingly rare but clinically significant occurrence.
Co-Authors Abdul Basit Ahmad, Hafiz Khush Naseeb Iftikhar, Shehla Manzoor, Hina Naheed, Hameeda Saeed, Hashir Shafiq, Sunnia Ullah, Sadiq Ur-Rehman, Awais